Multiple-functionalizations of terminal alkynes with sodium sulfinates and tert-butyl nitrite: facile synthesis of 2H-azirines

2019 ◽  
Vol 55 (24) ◽  
pp. 3517-3520 ◽  
Author(s):  
Xingyi He ◽  
Xin Yue ◽  
Lei Zhang ◽  
Shuang Wu ◽  
Ming Hu ◽  
...  
Keyword(s):  
Terminal Alkynes ◽  
Facile Synthesis ◽  
Tert Butyl ◽  
Catalyst Free

A new, catalyst-free tandem annulation route to 2,2-disulfonyl-2H-azirines via multiple-functionalizations of terminal alkynes with sodium sulfinates and tert-butyl nitrite is described.

Synthesis of β- and β,β-substituted Morita–Baylis–Hillman adducts using a two-step protocol

2012 ◽  
Vol 90 (5) ◽  
pp. 450-463 ◽  
Author(s):  
David I. Magee ◽  
Same Ratshonka ◽  
Jessica McConaghy ◽  
Maggie Hood
Keyword(s):  
Knoevenagel Condensation ◽  
Condensation Reaction ◽  
Facile Synthesis ◽  
Aliphatic Aldehydes ◽  
Tert Butyl ◽  
Keto Esters ◽  
Knoevenagel Condensation Reaction

The synthesis of a large number of β- and β,β-substituted keto esters was successful by the use of the Knoevenagel condensation reaction. The stereoselectivity of these reactions was improved by alteration of various substituent groups. Although there were few examples of complete Z selectivity, the use of tert-butyl acetoacetate with either aromatic or aliphatic aldehydes afforded Z selectivity. The selective reductions of these substituted keto esters was successfully achieved by using a combination of NaBH4 and CeCl3·7H2O or Yb(OTf)3, which allowed a facile synthesis of a large number of stereochemically pure substituted Morita–Baylis–Hillman adducts, including β,β-substituted adducts.

Catalyst-Free Regioselective C-3 Nitrosation of Imidazopyridines with tert-Butyl Nitrite under Neutral Conditions

Synthesis ◽  
2015 ◽  
Vol 48 (01) ◽  
pp. 122-130 ◽  
Author(s):  
Hua Wang ◽  
Daoshan Yang ◽  
Kelu Yan ◽  
Wei Wei ◽  
Yao Liu ◽  
...  
Keyword(s):  
Tert Butyl ◽  
Catalyst Free ◽  
Neutral Conditions

Facile synthesis of tert-butyl ester of N-protected amino acids with tert-butyl bromide

1993 ◽  
Vol 34 (46) ◽  
pp. 7409-7412 ◽  
Author(s):  
Pierre Chevallet ◽  
Patrick Garrouste ◽  
Barbara Malawska ◽  
Jean Martinez
Keyword(s):  
Amino Acids ◽  
Butyl Ester ◽  
Facile Synthesis ◽  
Butyl Bromide ◽  
Tert Butyl

scholarly journals Clickable azide-functionalized bromoarylaldehydes – synthesis and photophysical characterization

2020 ◽  
Vol 16 ◽  
pp. 1683-1692 ◽  
Author(s):  
Dominik Göbel ◽  
Marius Friedrich ◽  
Enno Lork ◽  
Boris J Nachtsheim
Keyword(s):  
High Efficiency ◽  
Photophysical Properties ◽  
Covalent Attachment ◽  
Terminal Alkynes ◽  
Facile Synthesis ◽  
Triazole Derivatives ◽  
Emission Behavior ◽  
Substituted Benzaldehydes ◽  
Covalently Linked

Herein, we present a facile synthesis of three azide-functionalized fluorophores and their covalent attachment as triazoles in Huisgen-type cycloadditions with model alkynes. Besides two ortho- and para-bromo-substituted benzaldehydes, the azide functionalization of a fluorene-based structure will be presented. The copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) of the so-synthesized azide-functionalized bromocarbaldehydes with terminal alkynes, exhibiting different degrees of steric demand, was performed in high efficiency. Finally, we investigated the photophysical properties of the azide-functionalized arenes and their covalently linked triazole derivatives to gain deeper insight towards the effect of these covalent linkers on the emission behavior.

scholarly journals Facile Synthesis of Functional Poly(methyltriazolylcarboxylate)s by Solvent- and Catalyst-free Butynoate-Azide Polycycloaddition

2019 ◽  
Vol 38 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Wei-Wen Chi ◽  
Rong-Yuan Zhang ◽  
Ting Han ◽  
Jian Du ◽  
Hong-Kun Li ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
Catalyst Free

ChemInform Abstract: Facile Synthesis of L-Dopa tert-Butyl Ester by Catalytic Enantioselective Phase-Transfer Alkylation.

ChemInform ◽  
2001 ◽  
Vol 32 (3) ◽  
pp. no-no
Author(s):  
Takashi Ooi ◽  
Minoru Kameda ◽  
Hidenori Tannai ◽  
Keiji Maruoka
Keyword(s):  
Phase Transfer ◽  
Butyl Ester ◽  
Facile Synthesis ◽  
Tert Butyl

Catalyst-free facile synthesis of polycyclic indole/pyrrole substituted-1,2,3-triazoles

2019 ◽  
Vol 17 (35) ◽  
pp. 8153-8165 ◽  
Author(s):  
Jitendra Gour ◽  
Srikanth Gatadi ◽  
Ravikumar Akunuri ◽  
Madhavi Venkata Yaddanapudi ◽  
Mushtaq Ahmad Nengroo ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Free Access ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
Catalyst Free

A general and catalyst-free access to the fused polycyclic N-heterocycles via an intramolecular azide–alkene cascade reaction under mild reaction conditions has been developed.

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