Nanoparticle size and chemical modification play a crucial role in the interaction of nano gold with the brain: extent of accumulation and toxicity

2020 ◽  
Vol 8 (6) ◽  
pp. 1669-1682 ◽  
Author(s):  
Nouf N. Mahmoud ◽  
Abdulrahim Albasha ◽  
Suhair Hikmat ◽  
Lama Hamadneh ◽  
Rand Zaza ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Crucial Role ◽  
Nanoparticle Size ◽  
High Brain ◽  
Nano Gold ◽  
The Brain

Short Mph-GNR show high brain accumulation percentage, while long GNR show low brain accumulation and high delivery into other organs.

scholarly journals Correction: Nanoparticle size and chemical modification play a crucial role in the interaction of nano gold with the brain: extent of accumulation and toxicity

2020 ◽  
Vol 8 (7) ◽  
pp. 2041-2041
Author(s):  
Nouf N. Mahmoud ◽  
Abdulrahim Albasha ◽  
Suhair Hikmat ◽  
Lama Hamadneh ◽  
Rand Zaza ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Crucial Role ◽  
Nanoparticle Size ◽  
Nano Gold ◽  
The Brain

Correction for ‘Nanoparticle size and chemical modification play a crucial role in the interaction of nano gold with the brain: extent of accumulation and toxicity’ by Nouf N. Mahmoud et al., Biomater. Sci., 2020, DOI: 10.1039/c9bm02072a.

Subjectivity as a sentient perspective and the role of interoception

2018 ◽  
Author(s):  
Helena De Preester
Keyword(s):  
Crucial Role ◽  
Point Of View ◽  
Basic Form ◽  
Bodily States ◽  
The Brain ◽  
Phenomenological Point

This chapter argues that the most basic form of subjectivity is different from and more fundamental than having a self, and forwards a hypothesis about the origin of subjectivity in terms of interoception. None of those topics are new, and a consensus concerning the homeostatic-interoceptive origin of subjectivity is rapidly growing in the domains of the neurosciences and psychology. This chapter critically explores that growing consensus, and it argues that the idea that the brain topographically represents bodily states is unfit for thinking about the coming about of subjectivity. In the first part, four inherent characteristics of subjectivity are discussed from a philosophical phenomenological point of view. The second part explores whether a model of subjectivity in which interoception maintains its crucial role is possible without relying on topographical representations of the in-depth body, and giving due to the inherent characteristics of subjectivity.

Abstract 421: The Subfornical Organ (SFO) Mediates CSF Na+ -induced Pressor Response via Activation of AT1 Receptors

Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Missale A Tiruneh ◽  
Bing S Huang ◽  
Frans H Leenen
Keyword(s):  
Crucial Role ◽  
Major Part ◽  
Wistar Rats ◽  
Pressor Response ◽  
Electrolytic Lesion ◽  
Induced Responses ◽  
Ang Ii ◽  
At1 Receptors ◽  
Pressor Responses ◽  
The Brain

In salt-sensitive rats on high salt or rats with icv infusion of Na + , the increase in CSF [Na + ] leads to activation of the brain renin-angiotensin-aldosterone system and thereby to sympatho-excitation and hypertension. We tested whether the SFO and AT 1 receptors in the SFO play a crucial role in mediating the Na + -induced responses. In conscious Wistar rats, intra-SFO infusion of Na + -rich aCSF increased BP in a dose-related manner, whereas mannitol with the same osmolarity had no effects. Intra-SFO infusion of the AT 1 receptor blocker candesartan (cand.,10 μg) abolished pressor responses to intra-SFO infusion of Ang II (80 ng) or Na + -rich aCSF (0.45-0.6 M NaCl), and prevented 50% of the BP increase induced by icv infusion of Na + -rich aCSF (0.3 M NaCl, 4 μl/min for 6 min). In another set of Wistar rats, electrolytic lesion of the SFO prevented 50-65% of BP increases induced by icv infusion of Na + -rich aCSF or Ang II (5 ng/min). These data suggest that the SFO neurons are Na + -sensitive and via AT 1 receptors mediate a major part of the pressor response to CSF Na + . Data=means±SE (n=5-7). *p<.05 vs vehicle or sham lesion.

Mental and behavioural disorders

2020 ◽  
pp. 333-365
Author(s):  
Fabrizio Benedetti
Keyword(s):  
Clinical Trials ◽  
Mental Disorders ◽  
Placebo Effect ◽  
Crucial Role ◽  
Drugs Of Abuse ◽  
Placebo Treatment ◽  
Brain Regions ◽  
Psychotherapeutic Interventions ◽  
Psychotherapeutic Outcome ◽  
The Brain

In this chapter some mental disorders are described. For example, in depression, fluoxetine treatment and a placebo treatment affect similar brain regions. In anxiety, patients’ expectations play a crucial role, as covert (unexpected) administration of anti-anxiety drugs is less effective than overt (expected) administration. The disruption of prefrontal executive control in Alzheimer’s disease decreases the magnitude of placebo responses. In addition, expectations appear to be particularly important when associated with the effects of drugs of abuse. Placebo effects appear to be powerful in psychotherapy as well, and the brain areas involved in the psychotherapeutic outcome are different from those involved in the placebo effect. As clinical trials for psychotherapeutic interventions represent a major problem, new recommendations are presented.

Unveiling the Cognitive Mechanisms of Eyes

2014 ◽  
Vol 8 (1) ◽  
pp. 36-50 ◽  
Author(s):  
Yingxu Wang
Keyword(s):  
Eye Movements ◽  
Knowledge Base ◽  
Crucial Role ◽  
Cognitive Mechanisms ◽  
Brain Science ◽  
Internal Memory ◽  
Cognitive Knowledge ◽  
The Mind ◽  
The Brain

Eyes as the unique organ possess intensively direct connections to the brain and dynamically perceptual accessibility to the mind. This paper analyzes the cognitive mechanisms of eyes not only as the sensory of vision, but also the browser of internal memory in thinking and perception. The browse function of eyes is created by abstract conditioning of the eye's tracking pathway for accessing internal memories, which enables eye movements to function as the driver of the perceptive thinking engine of the brain. The dual mechanisms of the eyes as both the external sensor of the brain and the internal browser of the mind are explained based on evidences and cognitive experiences in cognitive informatics, neuropsychology, cognitive science, and brain science. The finding on the experiment's internal browsing mechanism of eyes reveals a crucial role of eyes interacting with the brain for accessing internal memory and the cognitive knowledge base in thinking, perception, attention, consciousness, learning, memorization, and inference.

The Eisenstein-Vygotsky-Luria Collaboration

Projections ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 23-44 ◽  
Author(s):  
Julia Vassilieva
Keyword(s):  
Crucial Role ◽  
Cultural Psychology ◽  
Film Theory ◽  
Theory And Practice ◽  
Functional Architecture ◽  
Cultural Mediation ◽  
Sergei Eisenstein ◽  
Lev Vygotsky ◽  
Russian Film ◽  
The Brain

This article analyzes the unique historical collaboration between the revolutionary Russian film director Sergei Eisenstein (1898–1948), the cultural psychologist Lev Vygotsky (1896–1934), and the founder of contemporary neuropsychology, Alexander Luria (1902–1977). Vygotsky’s legacy is associated primarily with the idea that cultural mediation plays a crucial role in the emergence and development of personality and cognition. His collaborator, Luria, laid the foundations of contemporary neuropsychology and demonstrated that cultural mediation also changes the functional architecture of the brain. In my analysis, I demonstrate how the Eisenstein-Vygotsky-Luria collaboration exemplifies a strategy of productive triangulation that harnesses three disciplinary perspectives: those of cultural psychology, neuropsychology, and film theory and practice.

scholarly journals The brain renin-angiotensin system plays a crucial role in regulating body weight in diet-induced obesity in rats

2016 ◽  
Vol 173 (10) ◽  
pp. 1602-1617 ◽  
Author(s):  
Martina Winkler ◽  
Johanna Schuchard ◽  
Ines Stölting ◽  
Florian M Vogt ◽  
Jörg Barkhausen ◽  
...  
Keyword(s):  
Body Weight ◽  
Crucial Role ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Diet Induced Obesity ◽  
The Brain

scholarly journals Detection of Human Brain Activities in a Normal Human being

2019 ◽  
Vol 8 (10) ◽  
pp. 4004-4007
Keyword(s):  
Human Brain ◽  
Motor Imagery ◽  
Crucial Role ◽  
Software Tool ◽  
Eeg Signals ◽  
Eye Blink ◽  
Eye Blinks ◽  
Eeg Data ◽  
Normal Human ◽  
The Brain

Detection of artifacts produced in EEG data by eye blinks is a very common problem in EEG research. In this paper we address the detection of eye blink artifacts in a motor imagery (MI) EEG data. Artifacts are nothing but some kind of disturbances present in the brain signal whose origin is not the brain itself. Detection of unwanted artifacts plays a crucial role to acquire artifact free and clean brain EEG signals to analyze and detect brain activities. There are generally two ways of generation of artifacts. From a recorded signal most common and important artifacts in the form of eye blinks are recognized and encapsulated. In this paper a new software tool named BRAINSTORM is introduced for the detection of eye blink artifacts.

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