A self-assembled DNA tetrahedron as a carrier for in vivo liver-specific delivery of siRNA

2020 ◽  
Vol 8 (2) ◽  
pp. 586-590 ◽  
Author(s):  
Kyoung-Ran Kim ◽  
Hyun Jegal ◽  
Junghyun Kim ◽  
Dae-Ro Ahn
Keyword(s):  
Lipid Level ◽  
Blood Lipid ◽  
Blood Lipid Level ◽  
Dna Tetrahedron ◽  
Self Assembled

Liver-targeted DNA tetrahedron was employed as the carrier for liver-specific delivery of siRNA. Liver delivery of siRNA targeting ApoB1 mRNA, which is involved with hypercholesterolemia, lowered the blood lipid level.

scholarly journals PERBANDINGAN NILAI AGREGASI TROMBOSIT PADA PASIEN DIABETES MELITUS TIPE 2 DENGAN DISLIPIDEMIA DAN NORMOLIPIDEMIA DI RSUP PROF. DR. R. D. KANDOU MANADO

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Ivan Ch. Sulamanda
Keyword(s):  
Platelet Aggregation ◽  
Analytical Study ◽  
Platelet Reactivity ◽  
Hypothesis Test ◽  
Lipid Level ◽  
Blood Lipid ◽  
Normal Blood ◽  
Blood Lipid Level ◽  
Diabetes Melitus

Abstract: Insulin resistance that occurs in patients with type 2 diabetes mellitus (T2DM), stimulates lipolysis in adipose tissue resulting in increasing of free fatty acid and dyslipidemia. Dyslipidemia is associated with platelet reactivity and thrombogenic potency. Examination of platelet aggregation aims to detect abnormalities of platelet function. This study aimed to obtain the comparison of platelet aggregation values in T2DM patients with dyslipidemia and with normal blood lipid level. This was an observational analytical study, using comparative hypothesis test. This study were conducted on 30 T2DM patients, in which 15 of them have dyslipidemia and the other 15 has normal lipid level. These patients were registered as outpatients of Endocrine and Metabolic Clinic of Prof. Dr. R. D. Kandou Hospital, Manado. Blood samples of patients were processed in Prokita Laboratory, Manado. Platelet aggregation was tested by using 1 set agregometer Chrono - Log model 490, Chrono - Log recorder model 707, and Computer Windows based PC. The T test showed that there were significant differences of the platelet aggregation values with ADP 10 µm agonist between T2DM patients with dyslipidemia and with normal blood lipid level (P = 0.019). Mann-Whitney test showed that there were significant differences of the platelet aggregation values with ADP 5 µm agonist between T2DM patients with dyslipidemia and with normal blood lipid level (P = 0.006). Most patients in this study were elderly (86.7%), with an equal number of men and women. Conclusion: There were significant differences of the platelet aggregation values between T2DM patients with dyslipidemia and with normal blood lipid level, whether using ADP 10 µm agonist or ADP 5 µm agonist. Keywords: platelet aggregation, T2DM, dyslipidemiaAbstrak: Pada pasien diabetes melitus tipe 2 (DMT2), resistensi insulin merangsang lipolisis di jaringan adiposa yang meningkatkan asam lemak bebas sehingga terjadi dislipidemia. Dislipidemia sering dikaitkan dengan peningkatan aktivitas platelet dan potensi trombogenik. Pemeriksaan agregasi trombosit bertujuan untuk mendeteksi abnormalitas fungsi trombosit. Penelitian ini bertujuan untuk melihat perbandingan nilai agregasi trombosit pada pasien DMT2 dengan dislipidemia dan normolipidemia. Penelitian ini bersifat observasional analitik dengan menggunakan metode uji hipotesis komparatif. Subjek penelitian berjumlah 30 orang, terdiri dari 15 pasien DMT2 dengan dislipidemia dan 15 pasien DMT2 dengan normolipidemia yang berobat ke Poliklinik Endokrin Metabolik RSUP Prof. Dr. R. D. Kandou Manado. Pemeriksaan sampel darah pasien dilakukan di Laboratorium Prokita Manado. Pemeriksaan agregasi trombosit menggunakan 1 set agregometer Chrono - Log model 490, Chrono - Log recorder model 707, Computer Windows based PC. Karakteristik terbanyak pada pasien DMT2 terdapat pada usia tua (86,7%) dengan jenis kelamin laki - laki dan perempuan sama banyak (50%). Hasil uji T menunjukkan terdapat perbedaan bermakna antara nilai agregasi trombosit menggunakan agonis ADP 10 µm pada pasien DMT2 dengan dislipidemia dan normolipidemia (P = 0,019). Uji Mann-Whitney juga menunjukkan terdapat perbedaan bermakna antara nilai agregasi trombosit dengan agonis ADP 5 µm pada pasien DMT2 dengan dislipidemia dan normolipidemia (P = 0,006). Simpulan: Terdapat perbedaan bermakna antara nilai agregasi trombosit pada pasien DMT2 dengan dislipidemia dan normolipidemia baik menggunakan agonis ADP 10 µm maupun ADP 5 µm. Kata kunci: agregasi trombosit, DMT2, dislipidemia

In vitro studies on the interactions of blood lipid level‐related biological molecules with gallic acid and tannic acid

2019 ◽  
Vol 99 (15) ◽  
pp. 6882-6892 ◽  
Author(s):  
Xiangquan Zeng ◽  
Zhongting Sheng ◽  
Xiangxin Li ◽  
Xinguang Fan ◽  
Weibo Jiang
Keyword(s):  
Gallic Acid ◽  
Tannic Acid ◽  
Lipid Level ◽  
Blood Lipid ◽  
In Vitro Studies ◽  
Biological Molecules ◽  
Blood Lipid Level

Effect of low-ratio n-6/n-3 PUFA on blood lipid level: a meta-analysis

HORMONES ◽  
2020 ◽  
Author(s):  
Na Li ◽  
Min Jia ◽  
Qianchun Deng ◽  
Zhen Wang ◽  
Fenghong Huang ◽  
...  
Keyword(s):  
Lipid Level ◽  
Meta Analysis ◽  
Blood Lipid ◽  
Blood Lipid Level

scholarly journals Antioxidant Activity of β-Glucan

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Kyoko Kofuji ◽  
Ayumi Aoki ◽  
Kazufumi Tsubaki ◽  
Masanori Konishi ◽  
Takashi Isobe ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Extraction Method ◽  
Lipid Level ◽  
Food Additives ◽  
Molecular Size ◽  
Blood Lipid ◽  
Food Additive ◽  
Blood Lipid Level ◽  
Causal Factors

β-Glucans extracted from barley, which mainly contains β-(1,3-1,4)-D-glucan, are used extensively as supplements and food additives due to their wide biologic activities, including a reduction in blood lipid level. In this study, the antioxidant activity of β-glucan was examined to assess potential new benefits associated with β-glucan, because oxidative stress is considered one of the primary causal factors for various diseases and aging. β-Glucan extracted from barley was found to possess significant antioxidant activity. The amount of antioxidant activity was influenced by different physiologic properties (e.g., structure and molecular size) of β-glucan, which varied depending on the source and extraction method used. The antioxidant activity of β-glucan was significantly higher than that of various polymers that are used as food additives. These results indicate that β-glucan has promise as a polymeric excipient for supplement and food additive with antioxidant and other benefits, which may contribute to enhancing health and beauty.

scholarly journals Detection of Apolipoprotein E Gene Polymorphism and Blood Lipid Level in Hemodialysis Patients

2017 ◽  
Vol 9 (8) ◽  
pp. 695-700 ◽  
Author(s):  
Yuxin Wang ◽  
Ning Wang ◽  
Yuanshan Lu ◽  
Qing Yu ◽  
Lina Zhou ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Apolipoprotein E ◽  
Lipid Level ◽  
Blood Lipid ◽  
Hemodialysis Patients ◽  
Blood Lipid Level ◽  
E Gene ◽  
Apolipoprotein E Gene
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