Trastuzumab targeted micellar delivery of docetaxel using dendron–polymer conjugates

2020 ◽  
Vol 8 (9) ◽  
pp. 2600-2610 ◽  
Author(s):  
Burcu Sumer Bolu ◽  
Bianka Golba ◽  
Amitav Sanyal ◽  
Rana Sanyal
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Therapeutic Antibody ◽  
Target Specificity ◽  
Polymer Conjugates

Incorporation of a therapeutic antibody into nanosized drug delivery systems can improve their target specificity.

scholarly journals Drug Delivery Systems from Self-Assembly of Dendron-Polymer Conjugates †

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1570 ◽  
Author(s):  
Burcu Bolu ◽  
Rana Sanyal ◽  
Amitav Sanyal
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Polymer Conjugates

scholarly journals LIPOSOMES CONTAINING PHYTOCHEMICALS FOR CANCER TREATMENT-AN UPDATE

2016 ◽  
Vol 9 (1) ◽  
pp. 20 ◽  
Author(s):  
Yunus Y. Khan ◽  
Vasanti Suvarna
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
Aqueous Solubility ◽  
Delivery Systems ◽  
Target Specificity ◽  
Sustained Drug Delivery ◽  
Treatment And Prevention ◽  
Nano Drug Delivery

Many phytochemicals exhibit promising effects in treatment and prevention of various cancers, but due to their poor water solubility, stability, bio-availability and target specificity make administering them at therapeutic doses impractical. This is especially true for curcumin, quercetin, resveratrol and berberine. There is rising activity in developing nano drug delivery systems for these phytochemicals. These nano drug delivery systems mainly include liposomes, micelles, solid lipid nanoparticles, nanoemulsions, which are biocompatible and biodegradable nanoparticles. These nanoparticles can increase the stability and aqueous solubility of phytochemicals. They can also be used as sustained drug delivery systems. Much work has also proven that they enhance the absorption and bioavailability of the phytochemicals, protect them from premature enzymatic degradation or metabolism, hence prolonging their circulation time. Besides these parameters, in this review, we have also mentioned the improved target specificity of phytochemicals to cancer cells or tumours via passive or targeted delivery. Hence, nanotechnology cleared the way for developing phytochemical-loaded nanoparticles for prevention and treatment of cancer.

Bioinspired Engineering of Intelligent Drug Delivery Systems and Protein– Polymer Conjugates

2002 ◽  
Author(s):  
Patrick Stayton ◽  
Allan Hoffman ◽  
Oliver Press ◽  
Niren Murthy ◽  
Chantal Lackey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Polymer Conjugates ◽  
Protein Polymer

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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