Engineering microglia as intraoperative optical imaging agent vehicles potentially for fluorescence-guided surgery in gliomas

2020 ◽  
Vol 8 (4) ◽  
pp. 1117-1126
Author(s):  
Ling Guo ◽  
Xiaochen Zhang ◽  
Runxiu Wei ◽  
Gaojie Li ◽  
Bingzhi Sun ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Brain Tumors ◽  
Optical Imaging ◽  
Imaging Agent ◽  
Tumor Surgery ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
The Brain

Carotid artery injection of DiDBV2-Fe into glioblastoma-bearing mice and rats potentially for fluorescence-guided tumor surgery leads to significant accumulation and retention by the brain tumors.

Optical imaging probes and their potential contribution to radiotracer development

2016 ◽  
Vol 55 (02) ◽  
pp. 51-62 ◽  
Author(s):  
S. Hermann ◽  
M. Schäfers ◽  
C. Höltke ◽  
A. Faust
Keyword(s):  
Optical Imaging ◽  
Fluorescent Dyes ◽  
Great Influence ◽  
Potential Contribution ◽  
Preclinical Evaluation ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Imaging Probes ◽  
Unspecific Binding

SummaryOptical imaging has long been considered a method for histological or microscopic investigations. Over the last 15 years, however, this method was applied for preclinical molecular imaging and, just recently, was also able to show its principal potential for clinical applications (e.g. fluorescence-guided surgery). Reviewing the development and preclinical evaluation of new fluorescent dyes and target-specific dye conjugates, these often show characteristic patterns of their routes of excretion and biodistribution, which could also be interesting for the development and optimization of radiopharmaceuticals. Especially ionic charges show a great influence on biodistribution and netcharge and charge-distribution on a conjugate often determines unspecific binding or background signals in liver, kidney or intestine, and other organs.Learning from fluorescent probe behaviour in vivo and translating this knowledge to radio-pharmaceuticals might be useful to further optimize emerging and existing radiopharmaceuticals with respect to their biodistribution and thereby availability for binding to their targets.

5-ALA fluorescence–guided surgery in pediatric brain tumors—a systematic review

2019 ◽  
Vol 161 (6) ◽  
pp. 1099-1108 ◽  
Author(s):  
Michael Schwake ◽  
Stephanie Schipmann ◽  
Michael Müther ◽  
Michaela Köchling ◽  
Angela Brentrup ◽  
...  
Keyword(s):  
Systematic Review ◽  
Brain Tumors ◽  
Pediatric Brain Tumors ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Pediatric Brain

scholarly journals Combination of hand-held probe and microscopy for fluorescence guided surgery in the brain tumor marginal zone

2017 ◽  
Vol 18 ◽  
pp. 185-192 ◽  
Author(s):  
Johan C.O. Richter ◽  
Neda Haj-Hosseini ◽  
Martin Hallbeck ◽  
Karin Wårdell
Keyword(s):  
Brain Tumor ◽  
Marginal Zone ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
The Brain

scholarly journals Fluorescence-guided surgery for brain tumors

CNS Oncology ◽  
2013 ◽  
Vol 2 (1) ◽  
pp. 67-74 ◽  
Author(s):  
Martin Hefti
Keyword(s):  
Brain Tumors ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery

scholarly journals Prediction of optimal contrast times post-imaging agent administration to inform personalized fluorescence-guided surgery

2020 ◽  
Vol 25 (11) ◽  
Author(s):  
Negar Sadeghipour ◽  
Aakanksha Rangnekar ◽  
Margaret R. Folaron ◽  
Rendall R. Strawbridge ◽  
Kimberley S. Samkoe ◽  
...  
Keyword(s):  
Imaging Agent ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery
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