scholarly journals Multi-component supramolecular fibers with elastomeric properties and controlled drug release

2020 ◽  
Vol 8 (1) ◽  
pp. 163-173 ◽  
Author(s):  
Matilde Putti ◽  
Tristan Mes ◽  
Jingyi Huang ◽  
Anton W. Bosman ◽  
Patricia Y. W. Dankers
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Sustained Drug Release ◽  
Load Bearing ◽  
Combine Load

Supramolecular fibers fabricated by co-axial electrospinning combine load-bearing properties and sustained drug release of hydrophobic and UPy-modified drugs.

scholarly journals pH-Sensitive Polyampholyte Microgels of Poly(Acrylic Acid-co-Vinylamine) as Injectable Hydrogel for Controlled Drug Release

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 285 ◽  
Author(s):  
Yanmin Chen ◽  
Peijian Sun
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Zeta Potential ◽  
Suspension Polymerization ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Swelling Ratio ◽  
Sustained Drug Release ◽  
Injectable Hydrogel ◽  
Poly Acrylic Acid

pH-sensitive polyampholyte microgels of poly(acrylic acid-co-vinylamine) (P(AA-co-VAm)) were developed as an injectable hydrogel for controlled drug release. The microgels of P(AA-co-VAm) were prepared via inverse suspension polymerization of acrylic acid and N-vinylformamide followed by hydrolysis of poly(N-vinylformamide) (PNVF) chains of the resultant microgels under basic condition. The pH-sensitivity of the P(AA-co-VAm) microgels in zeta potential and swelling ratio were investigated using a zeta potential analyzer and optical microscope. The results showed that both the zeta potential and the swelling ratio of the microgels were highly affected by the solution pH. By changing the pH of P(AA-co-VAm) microgel dispersion, the interparticle interaction and the swelling ratio of the microgels could be well adjusted and a colloidal hydrogel could be fabricated at moderate pH, showing a pH-triggered reversible fluid-gel transition. Using the polyampholyte P(AA-co-VAm) microgels as an injectable hydrogel drug release system, a sustained drug release could be achieved, indicating the great potentials of the pH-sensitive P(AA-co-VAm) microgels for controlled drug delivery.

scholarly journals Surfactant Mediated Synthesis of Polyhydroxybutyrate (PHB) Nanoparticles for Sustained Drug Delivery

2020 ◽  
Vol 2 (1) ◽  
pp. 41
Keyword(s):  
Drug Release ◽  
Functional Group ◽  
Antibacterial Effect ◽  
Polymeric Nanoparticles ◽  
Controlled Drug Release ◽  
Sustained Drug Release ◽  
Bacterial Fermentation ◽  
Sustained Drug Delivery ◽  
Nanoprecipitation Method ◽  
Living Organisms

Polyhydroxyalkanoates are produced by bacterial fermentation that contains ester as their functional group. Polymeric substances derived from living organisms are captivating owing to the fact of their adaptability, biocompatibility, and biodegradability. The main objective of this study is to develop polymeric nanoparticles through the nanoprecipitation method using the PHA extracted from Pseudomonas aeruginosa. In this study, PHA extracted was characterized and determined as Polyhydroxybutyrate. The PHA was further used to produce nanoparticles by nanoprecipitation method using Dichloromethane as a solvent and subjected to various characterizations such as Ultraviolet-Visible spectroscopy (UV-Vis), Fourier Infra-Red spectroscopy (FTIR), Field Emission Scanning Electron microscopy (FeSEM) and further tested for sustained drug release. Nanoparticles prepared by the nanoprecipitation method had a size with invariable dissemination. Curcumin loaded PHA nanoparticles displayed a competent antibacterial effect against Bacillus subtilis. A controlled drug release was exhibited.

Mucoadhesive Formulation Designs for Oral Controlled Drug Release at the Colon

2020 ◽  
Vol 26 ◽  
Author(s):  
Phuong H.L. Tran ◽  
Thao T.D. Tran
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Basic Principle ◽  
Oral Delivery ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Sustained Drug Release ◽  
Mucosal Tissues

: Mucoadhesive formulations have been demonstrated to result in efficient drug delivery systems with advantages over existing systems such as increased local retention and sustained drug release via adhesiveness to mucosal tissues. The controlled release of colon-targeted, orally administered drugs has recently attracted a number of studies investigating mucoadhesive systems. Consequently, substantial designs, from mucoadhesive cores to shells of particles, have been studied with promising applications. This review will provide an overview of and discuss specific strategies for developing mucoadhesive systems for colon-targeted oral delivery with controlled drug release, including mucoadhesive matrices, cross-linked mucoadhesive microparticles, coatings and mucoadhesive nanoparticles. The understanding of the basic principle of these designs and advanced formulations throughout will lead to the development of products with efficient drug delivery at the colon for therapies for different diseases.

scholarly journals Development of Functionalized Carbon Nano-Onions Reinforced Zein Protein Hydrogel Interfaces for Controlled Drug Release

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 621 ◽  
Author(s):  
Narsimha Mamidi ◽  
Aldo González-Ortiz ◽  
Irasema Lopez Romo ◽  
Enrique V. Barrera
Keyword(s):  
Drug Release ◽  
Colloidal Stability ◽  
Controlled Drug Release ◽  
Acoustic Cavitation ◽  
Drug Transporter ◽  
Ph Responsive ◽  
Sustained Drug Release ◽  
In Vitro Degradation ◽  
Selective Delivery

In the current study, poly 4-mercaptophenyl methacrylate-carbon nano-onions (PMPMA-CNOs = f-CNOs) reinforced natural protein (zein) composites (zein/f-CNOs) are fabricated using the acoustic cavitation technique. The influence of f-CNOs inclusion on the microstructural properties, morphology, mechanical, cytocompatibility, in-vitro degradation, and swelling behavior of the hydrogels are studied. The tensile results showed that zein/f-CNOs hydrogels fabricated by the acoustic cavitation system exhibited good tensile strength (90.18 MPa), compared with the hydrogels fabricated by the traditional method and only microwave radiation method. It reveals the magnitude of physisorption and degree of colloidal stability of f-CNOs within the zein matrix under acoustic cavitation conditions. The swelling behaviors of hydrogels were also tested and improved results were noticed. The cytotoxicity of hydrogels was tested with osteoblast cells. The results showed good cell viability and cell growth. To explore the efficacy of hydrogels as drug transporters, 5-fluorouracil (5-FU) release was measured under gastric and intestinal pH environment. The results showed pH-responsive sustained drug release over 15 days of study, and pH 7.4 showed a more rapid drug release than pH 2.0 and 4.5. Nonetheless, all the results suggest that zein/f-CNOs hydrogel could be a potential pH-responsive drug transporter for a colon-selective delivery system.

scholarly journals Controlled Drug Release from Biodegradable Polymer Matrix Loaded in Microcontainers Using Hot Punching

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1050 ◽  
Author(s):  
Ritika Singh Petersen ◽  
Line Hagner Nielsen ◽  
Tomas Rindzevicius ◽  
Anja Boisen ◽  
Stephan Sylvest Keller
Keyword(s):  
Drug Release ◽  
Biodegradable Polymer ◽  
Drug Distribution ◽  
Controlled Drug Release ◽  
Single Step ◽  
Zero Order ◽  
Sustained Drug Release ◽  
Small Molecule Drugs ◽  
Model Drug ◽  
A New Technique

Microcontainers are reservoir-based advanced drug delivery systems (DDS) that have proven to increase the bioavailibity of the small-molecule drugs, targeting of biomolecules, protection of vaccines and improved treatment of Pseudomonas aeruginosa. However, high-throughput loading of these micron-sized devices with drug has been challenging. Hot punching is a new technique that is a fast, simple and single-step process where the microdevices are themselves used as mold to punch biocompatible and biodegradable drug-polymer films, thereby loading the containers. Here, we investigate the effect of hot punching on the drug distribution as well as drug release from the loaded drug-polymer matrices. Zero-order sustained drug release is observed for the model drug Furosemide embedded in biodegradable polymer, Poly-ε-caprolactone, which is attributed to the unique spatial distribution of Furosemide during the loading process.

scholarly journals Hyaluronic Acid and Controlled Release: A Review

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2649 ◽  
Author(s):  
Ilker S. Bayer
Keyword(s):  
Hyaluronic Acid ◽  
Controlled Release ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Surface Glycoprotein ◽  
Cancer Drug ◽  
Therapeutic Effects ◽  
Sustained Drug Release ◽  
Cell Surface Glycoprotein

Hyaluronic acid (HA) also known as hyaluronan, is a natural polysaccharide—an anionic, non-sulfated glycosaminoglycan—commonly found in our bodies. It occurs in the highest concentrations in the eyes and joints. Today HA is used during certain eye surgeries and in the treatment of dry eye disease. It is a remarkable natural lubricant that can be injected into the knee for patients with knee osteoarthritis. HA has also excellent gelling properties due to its capability to bind water very quickly. As such, it is one the most attractive controlled drug release matrices and as such, it is frequently used in various biomedical applications. Due to its reactivity, HA can be cross-linked or conjugated with assorted bio-macromolecules and it can effectively encapsulate several different types of drugs, even at nanoscale. Moreover, the physiological significance of the interactions between HA and its main membrane receptor, CD44 (a cell-surface glycoprotein that modulates cell–cell interactions, cell adhesion and migration), in pathological processes, e.g., cancer, is well recognized and this has resulted in an extensive amount of studies on cancer drug delivery and tumor targeting. HA acts as a therapeutic but also as a tunable matrix for drug release. Thus, this review focuses on controlled or sustained drug release systems assembled from HA and its derivatives. More specifically, recent advances in controlled release of proteins, antiseptics, antibiotics and cancer targeting drugs from HA and its derivatives were reviewed. It was shown that controlled release from HA has many benefits such as optimum drug concentration maintenance, enhanced therapeutic effects, improved efficiency of treatment with less drug, very low or insignificant toxicity and prolonged in vivo release rates.

IN VITROCHARACTERIZATION OF TRAMADOL-HCL-LOADED POLYOXALATE MICROSPHERES DESIGNED FOR CONTROLLED DRUG RELEASE

2015 ◽  
Vol 27 (03) ◽  
pp. 1550022
Author(s):  
Cheon Jung Lee ◽  
Su Young Kim ◽  
Hyun Gu Lee ◽  
Jaewon Yang ◽  
Jin Young Park ◽  
...  
Keyword(s):  
Drug Release ◽  
High Performance ◽  
Controlled Drug Release ◽  
Physicochemical Characteristics ◽  
In Vitro Test ◽  
X Ray Diffraction ◽  
Sustained Drug Release ◽  
Release Formulation ◽  
Preparation Conditions

This study evaluates the properties of Tramadol- HCl -loaded polyoxalate (TH-loaded POX) microspheres prepared by oil-in-oil (O1/O2) emulsion solvent evaporation method, specifically designed for sustained drug release. Morphology and physicochemical characteristics of the as-fabricated were studied by scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimeter (DSC) and Fourier transform infrared (FTIR) spectroscopy, while the encapsulation efficiency and release profile of drug (Tramadol- HCl , TH) from POX microspheres were assessed by high-performance liquid chromatography (HPLC). The influence of reaction temperature, stirring speed, initial drug ratio, molecular weight (Mw) and concentration of polyoxalate (POX) on the fabrication of TH-loaded POX microspheres were investigated. Results showed that the characteristics of the microspheres and drug-loaded content can be optimized by adjusting the parameters of preparation conditions. Also, the degradation behavior of TH-loaded POX microspheres was evaluated from in vitro test for 2 weeks. Overall, the results showed that POX microsphere can be one of the promising polymers for controlled injection release formulation with site-specific drug release capabilities.

Synthesis, Characterization and in-vitro drug release studies of a macromolecular prodrug of Didanosine.

2010 ◽  
Vol 2 (2) ◽  
Author(s):  
Neeraj Agrawal ◽  
M.J. Chandrasekar ◽  
U.V. Sara ◽  
Rohini A.
Keyword(s):  
Drug Release ◽  
Drug Level ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
In Vitro Drug Release ◽  
Alkaline Environment ◽  
Stomach Acid ◽  
Release Studies ◽  
Macromolecular Prodrug

A macromolecular prodrug of didanosine (ddI) for oral administration was synthesized and evaluated for in-vitro drug release profile. Didanosine was first coupled to 2-hydroxy ethyl methacrylate (HEMA) through a succinic spacer to form HEMA-Suc-ddI monomeric conjugate which was subsequently polymerized to yield Poly(HEMA-Suc-ddI) conjugate. The structures of the synthesized compounds were characterized by FT-IR, Mass and 1H-NMR spectroscopy. The prodrug was subjected for in-vitro drug release studies in buffers of pH 1.2 and 7.4 mimicking the upper and lower GIT. The results showed that the drug release from the polymeric backbone takes place in a sustained manner over a period of 24 h and the amount of drug released was comparatively higher at pH 7.4 indicating that the drug release takes place predominantly at the alkaline environment of the lower GIT rather than at the acidic environment of the upper GIT. This pH dependent sustained drug release behavior of the prodrug may be capable of reducing the dose limiting toxicities by maintaining the plasma drug level within the therapeutic range and increasing t1/2 of ddI. Moreover, the bioavailability of the drug should be improved as the prodrug releases ddI predominantly in the alkaline environment which will reduce the degradation of ddI in the stomach acid.

Formulation and Evaluation of Chitosan-Polyaniline Nanocomposites for Controlled Release of Anticancer Drug Doxorubicin

2018 ◽  
Vol 8 (2) ◽  
Author(s):  
Dillip Kumar Behera ◽  
Kampal Mishra ◽  
Padmolochan Nayak
Keyword(s):  
Tensile Strength ◽  
Drug Release ◽  
Nanocomposite Films ◽  
Casting Method ◽  
Sustained Drug Release ◽  
In Vitro Drug Release ◽  
Clay Particles ◽  
Solution Casting Method ◽  
Nanoclay Content

In this present work, chitosan (CS) crosslink with polyaniline (PANI) with montmorilonite (MMT) called as (CSPANI/MMT) and CS crosslink with PANI without MMT called as (CS-PANI) were prepared by employing the solution casting method. Further the formation of nanocomposites CS-PANI/MMT and CS-PANI were investigated using XRD, FTIR, SEM and tensile strength. Water uptake and swelling ratio of the CS-PANI and CS-PANI/MMT were found to decrease with increase in concentration of clay. Mechanical properties of the CS-PANI and CS-PANI/MMT were assessed in terms of tensile strength and extensibility using texture analyzer. Increase in tensile strength and reduction in extensibility was reported with increase in the nanoclay content. In vitro drug release study on CS-PANI and CS-PANI/MMT indicated pronounced sustained release of doxorubicin by the incorporation of clay particles in the CS polymer matrix. Overall CSPANI/MMT nanocomposite films exhibited improved mechanical and sustained drug release properties than CS-PANI.

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