Preparation and evaluation of PAMAM dendrimer-based polymer gels physically cross-linked by hydrogen bonding

2019 ◽  
Vol 7 (9) ◽  
pp. 3918-3925 ◽  
Author(s):  
Hailin Cong ◽  
Liping Zhou ◽  
Qingye Meng ◽  
Yixin Zhang ◽  
Bing Yu ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Antibacterial Properties ◽  
Polymer Gels ◽  
Pamam Dendrimer ◽  
Covalent Bonding ◽  
Cross Linking ◽  
Anti Inflammatory ◽  
Preparation And Evaluation

Dendrimer-based polymer gels with good antibacterial properties and anti-inflammatory properties were prepared without any covalent bonding cross-linking agents.

scholarly journals Farnesol-Loaded Liposomes Protect the Epidermis and Dermis from PM2.5-Induced Cutaneous Injury

2021 ◽  
Vol 22 (11) ◽  
pp. 6076
Author(s):  
Yu-Chiuan Wu ◽  
Wei-Yun Chen ◽  
Chun-Yin Chen ◽  
Sheng I. Lee ◽  
Yu-Wen Wang ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Water Solubility ◽  
Antibacterial Properties ◽  
Hair Follicles ◽  
Protective Effects ◽  
Cutaneous Injury ◽  
Anti Inflammatory ◽  
High Concentrations ◽  
Acute And Chronic Inflammation

Particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5) increases oxidative stress through free radical generation and incomplete volatilization. In addition to affecting the respiratory system, PM2.5 causes aging- and inflammation-related damage to skin. Farnesol (Farn), a natural benzyl semiterpene, possesses anti-inflammatory, antioxidative, and antibacterial properties. However, because of its poor water solubility and cytotoxicity at high concentrations, the biomedical applications of Farn have been limited. This study examined the deleterious effects of PM2.5 on the epidermis and dermis. In addition, Farn-encapsulated liposomes (Lipo-Farn) and gelatin/HA/xanthan gel containing Lipo-Farn were prepared and applied in vivo to repair and alleviate PM2.5-induced damage and inflammation in skin. The prepared Lipo-Farn was 342 ± 90 nm in diameter with an encapsulation rate of 69%; the encapsulation significantly reduced the cytotoxicity of Farn. Lipo-Farn exhibited a slow-release rate of 35% after 192 h of incubation. The half-maximal inhibitory concentration of PM2.5 was approximately 850 μg/mL, and ≥400 μg/mL PM2.5 significantly increased IL-6 production in skin fibroblasts. Severe impairment in the epidermis and hair follicles and moderate impairment in the dermis were found in the groups treated with post-PM2.5 and continuous subcutaneous injection of PM2.5. Acute and chronic inflammation was observed in the skin in both experimental categories in vivo. Treatment with 4 mM Lipo-Farn largely repaired PM2.5-induced injury in the epidermis and dermis, restored injured hair follicles, and alleviated acute and chronic inflammation induced by PM2.5 in rat skin. In addition, treatment with 4 mM pure Farn and 2 mM Lipo-Farn exerted moderate reparative and anti-inflammatory effects on impaired skin. The findings of the current study indicate the therapeutic and protective effects of Lipo-Farn against various injuries caused by PM2.5 in the pilosebaceous units, epidermis, and dermis of skin.

scholarly journals Smart Hydrogel Bilayers Prepared by Irradiation

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1753
Author(s):  
Weixian Huo ◽  
Heng An ◽  
Shuquan Chang ◽  
Shengsheng Yang ◽  
Yin Huang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Gamma Radiation ◽  
Antibacterial Properties ◽  
Cross Linking ◽  
Temperature Sensitive ◽  
Temperature Changes ◽  
Smart Hydrogel ◽  
Isopropyl Acrylamide ◽  
Hydrogel Synthesis ◽  
Potential Applications

Environment-responsive hydrogel actuators have attracted tremendous attention due to their intriguing properties. Gamma radiation has been considered as a green cross-linking process for hydrogel synthesis, as toxic cross-linking agents and initiators were not required. In this work, chitosan/agar/P(N-isopropyl acrylamide-co-acrylamide) (CS/agar/P(NIPAM-co-AM)) and CS/agar/Montmorillonite (MMT)/PNIPAM temperature-sensitive hydrogel bilayers were synthesized via gamma radiation at room temperature. The mechanical properties and temperature sensitivity of hydrogels under different agar content and irradiation doses were explored. The enhancement of the mechanical properties of the composite hydrogel can be attributed to the presence of agar and MMT. Due to the different temperature sensitivities provided by the two layers of hydrogel, they can move autonomously and act as a flexible gripper as the temperature changes. Thanks to the antibacterial properties of the hydrogel, their storage time and service life may be improved. The as prepared hydrogel bilayers have potential applications in control devices, soft robots, artificial muscles and other fields.

Structure and hydrogen bonding inCaSiD1+x: Issues about covalent bonding

2006 ◽  
Vol 74 (22) ◽  
Author(s):  
H. Wu ◽  
W. Zhou ◽  
T. J. Udovic ◽  
J. J. Rush ◽  
T. Yildirim
Keyword(s):  
Hydrogen Bonding ◽  
Covalent Bonding

Novel Hydrogen-Bonding Cross-Linking Aggregation-Induced Emission: Water as a Fluorescent “Ribbon” Detected in a Wide Range

2017 ◽  
Vol 9 (18) ◽  
pp. 15744-15757 ◽  
Author(s):  
Ani Wang ◽  
Ruiqing Fan ◽  
Yuwei Dong ◽  
Yang Song ◽  
Yuze Zhou ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Cross Linking ◽  
Aggregation Induced Emission ◽  
Wide Range

scholarly journals Biological Activity of the Methanol and Water Extracts of the Fruits of Anthocyanin-Rich Plants Grown in South-West Poland

2015 ◽  
Vol 10 (3) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Paulina Strugala ◽  
Anna Dudra ◽  
Alicja Z. Kucharska ◽  
Anna Sokół-Łętowska ◽  
Dorota Wojnicz ◽  
...  
Keyword(s):  
Free Radical ◽  
Biological Effects ◽  
Radical Scavenging ◽  
Antibacterial Properties ◽  
Bacterial Biofilm ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Water Extracts ◽  
South West ◽  
Anti Inflammatory

In this study we focused on the chemical composition, antioxidant, anti-inflammatory and antibacterial properties of methanol and water extracts of fruits of six species grown in south-west Poland: blackberry, blackcurrant, chokeberry, cherry, gooseberry and raspberry. No general correlation could be drawn between extract chemical properties (i.e. antioxidant and free radical scavenging) and observed biological effects. However, blackcurrant and blackberry extracts (both methanol and water) appeared to be good antioxidants and free radical scavengers, as well as effective inhibitors of E. coli adhesion to the uroepithelial cells. On the other hand, the poorest antioxidants and free radical scavengers, cherry and gooseberry extracts, also poorly affected bacterial growth, swimming ability and adhesion to epithelial cells. Surprisingly, gooseberry extracts, which showed generally weak effects, appeared to be the most effective inhibitor of bacterial biofilm formation. Additionally, most of the studied extracts showed reasonably strong anti-inflammatory properties.

SU-GG-T-308: Polymer Cross-Linking and Sensitivity Enhancement in Normoxic Polymer Gels Used for Three-Dimensional Dosimetry

2008 ◽  
Vol 35 (6Part14) ◽  
pp. 2796-2796
Author(s):  
R Martin ◽  
J BenComo ◽  
M Heard ◽  
M Martin ◽  
K Kaluarachchi ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Polymer Gels ◽  
Sensitivity Enhancement ◽  
Cross Linking

scholarly journals Study on Optimization of Damping Performance and Damping Temperature Range of Silicone Rubber by Polyborosiloxane Gel

Polymers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1196 ◽  
Author(s):  
Jiang Zhao ◽  
Nan Jiang ◽  
Dongsheng Zhang ◽  
Bobing He ◽  
Xian Chen
Keyword(s):  
Silicone Rubber ◽  
Intermolecular Forces ◽  
Mechanical Analysis ◽  
Covalent Bonding ◽  
Cross Linking ◽  
Damping Properties ◽  
Transfer Energy ◽  
Covalent Bonds ◽  
Combined Action ◽  
Rheological Test

Polyborosiloxane gel (PBS-gel) with shear hardening properties was prepared by cross-linking boric acid and hydroxyl-terminated polydimethylsiloxane through B–O–Si dynamic covalent bonding. The prepared PBS gel was mixed with methyl vinyl silicone rubber (MVQ), and a benzoyl peroxide (BPO) cross-linking agent was added to vulcanize the silicone rubber. At the same time, the gel molecules were co-vulcanizing with MVQ to produce molecular cross-linking. The effects of PBS-gel on the damping properties of silicone rubber were analyzed by dynamic rheological test, Fourier transform infrared spectroscopy and dynamic mechanical analysis. The results demonstrated that the damping performance of MVQ/PBS rubber is greatly improved and the rubber has a tanδ > 0.3 in the range of −25~125 °C. The shear-hardening gel is uniformly dispersed in the system, due to the combined action of covalent bonds and intermolecular forces, which act as an active molecular chain that can efficiently dissipate and transfer energy inside the silicone rubber.

A fluorescent “glue” of water triggered by hydrogen-bonding cross-linking

2016 ◽  
Vol 4 (47) ◽  
pp. 11050-11054 ◽  
Author(s):  
Dejia Wang ◽  
Hongwei Zhao ◽  
Hongjuan Li ◽  
Shiguo Sun ◽  
Yongqian Xu
Keyword(s):  
Hydrogen Bonding ◽  
Organic Solvents ◽  
Organic Molecule ◽  
Linear Range ◽  
Cross Linking ◽  
The Novel ◽  
Aggregation Induced Emission ◽  
Small Organic Molecule ◽  
Wide Linear Range ◽  
Trace Water

As a “glue” of water, a small organic molecule with the novel hydrogen-bonding cross-linked aggregation-induced emission (AIE) property was designed to detect trace water, displaying a wide linear range (0–40%, v/v) in most of the organic solvents.

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