The “nano to micro” transition of hydrophobic curcumin crystals leading to in situ adjuvant depots for Au-liposome nanoparticle mediated enhanced photothermal therapy

2019 ◽  
Vol 7 (9) ◽  
pp. 3866-3875 ◽  
Author(s):  
Syed Baseeruddin Alvi ◽  
Tejaswini Appidi ◽  
B. Pemmaraju Deepak ◽  
P. S. Rajalakshmi ◽  
Gillipsie Minhas ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Photothermal Therapy ◽  
Therapeutic Outcome

The transition of curcumin from nano to micro depots adhering to the cancer cell membrane aids in their localized availability. Thereby enhancing the therapeutic outcome.

Delicately Designed Cancer Cell Membrane-Camouflaged Nanoparticles for Targeted 19F MR/PA/FL Imaging-Guided Photothermal Therapy

2020 ◽  
Vol 12 (51) ◽  
pp. 57290-57301
Author(s):  
Sha Li ◽  
Weiping Jiang ◽  
Yaping Yuan ◽  
Meiju Sui ◽  
Yuqi Yang ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Photothermal Therapy

Cancer cell membrane-coated gold nanorods for photothermal therapy and radiotherapy on oral squamous cancer

2020 ◽  
Vol 8 (32) ◽  
pp. 7253-7263
Author(s):  
Qiang Sun ◽  
Jinggen Wu ◽  
Lulu Jin ◽  
Liangjie Hong ◽  
Fang Wang ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Squamous Cancer

Cancer cell membrane-coated gold nanorods are prepared for combinational photothermal therapy and radiation therapy of oral squamous cancer.

Cancer Cell Membrane–Biomimetic Nanoparticles for Homologous-Targeting Dual-Modal Imaging and Photothermal Therapy

ACS Nano ◽  
2016 ◽  
Vol 10 (11) ◽  
pp. 10049-10057 ◽  
Author(s):  
Ze Chen ◽  
Pengfei Zhao ◽  
Zhenyu Luo ◽  
Mingbin Zheng ◽  
Hao Tian ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Photothermal Therapy ◽  
Biomimetic Nanoparticles

In Situ Electrophoresis of Cancer Cell Membrane Components

1983 ◽  
Vol 97 (1) ◽  
pp. 317-324
Author(s):  
Y.-S. Nie ◽  
Y.-B. Feng ◽  
M.-Q. Tan ◽  
N.-M. Chao ◽  
D.-P. Zhao
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Membrane Components

scholarly journals Biomimetic Upconversion Nanoparticles and Gold Nanoparticles for Novel Simultaneous Dual-Modal Imaging-Guided Photothermal Therapy of Cancer

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3136 ◽  
Author(s):  
Ruliang Wang ◽  
Han Yang ◽  
Rongxin Fu ◽  
Ya Su ◽  
Xue Lin ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Imaging System ◽  
Imaging Systems ◽  
Coated Nanoparticles ◽  
Cancer Theranostics

Multimodal imaging-guided near-infrared (NIR) photothermal therapy (PTT) is an interesting and promising cancer theranostic method. However, most of the multimodal imaging systems provide structural and functional information used for imaging guidance separately by directly combining independent imaging systems with different detectors, and many problems arise when trying to fuse different modal images that are serially taken by inviting extra markers or image fusion algorithms. Further, most imaging and therapeutic agents passively target tumors through the enhanced permeability and retention (EPR) effect, which leads to low utilization efficiency. To address these problems and systematically improve the performance of the imaging-guided PTT methodology, we report a novel simultaneous dual-modal imaging system combined with cancer cell membrane-coated nanoparticles as a platform for PTT-based cancer theranostics. A novel detector with the ability to detect both high-energy X-ray and low-energy visible light at the same time, as well as a dual-modal imaging system based on the detector, was developed for simultaneous dual-modal imaging. Cancer cell membrane-coated upconversion nanoparticles (CC-UCNPs) and gold nanoparticles (CC-AuNPs) with the capacity for immune evasion and active tumor targeting were engineered for highly specific imaging and high-efficiency PTT therapy. In vitro and in vivo evaluation of macrophage escape and active homologous tumor targeting were performed. Cancer cell membrane-coated nanoparticles (CC-NPs) displayed excellent immune evasion ability, longer blood circulation time, and higher tumor targeting specificity compared to normal PEGylated nanoparticles, which led to highly specific upconversion luminescence (UCL) imaging and PTT-based anti-tumor efficacy. The anti-cancer efficacy of the dual-modal imaging-guided PTT was also evaluated both in vitro and in vivo. Dual-modal imaging yielded precise anatomical and functional information for the PTT process, and complete tumor ablation was achieved with CC-AuNPs. Our biomimetic UCNP/AuNP and novel simultaneous dual-modal imaging combination could be a promising platform and methodology for cancer theranostics.

The role of (bio)surfactant sorption in promoting the bioavailability of nutrients localized at the solid-water interface

1999 ◽  
Vol 39 (7) ◽  
pp. 91-98 ◽  
Author(s):  
Ryan N. Jordan ◽  
Eric P. Nichols ◽  
Alfred B. Cunningham
Keyword(s):  
Mass Transfer ◽  
Cell Membrane ◽  
Substrate Concentration ◽  
Water Interface ◽  
Industrial Systems ◽  
Solid Liquid Interface ◽  
Solid Liquid ◽  
Surfactant Sorption

Bioavailability is herein defined as the accessibility of a substrate by a microorganism. Further, bioavailability is governed by (1) the substrate concentration that the cell membrane “sees,” (i.e., the “directly bioavailable” pool) as well as (2) the rate of mass transfer from potentially bioavailable (e.g., nonaqueous) phases to the directly bioavailable (e.g., aqueous) phase. Mechanisms by which sorbed (bio)surfactants influence these two processes are discussed. We propose the hypothesis that the sorption of (bio)surfactants at the solid-liquid interface is partially responsible for the increased bioavailability of surface-bound nutrients, and offer this as a basis for suggesting the development of engineered in-situ bioremediation technologies that take advantage of low (bio)surfactant concentrations. In addition, other industrial systems where bioavailability phenomena should be considered are addressed.

Theoretical Study of the Process of Passage of Glycoside Amides through the Cell Membrane of Cancer Cell

2020 ◽  
Vol 20 ◽  
Author(s):  
Vasil Tsanov ◽  
Hristo Tsanov
Keyword(s):  
Cell Membrane ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Quantum Chemical ◽  
Density Functional ◽  
Enzyme Regulation ◽  
Amide Derivatives ◽  
Pass Through ◽  
Hydrolysis Of ◽  
Derivatives Of

Background:: This article concentrates on the processes occurring in the medium around the cancer cell and the transfer of glycoside amides through their cell membrane. They are obtained by modification of natural glycoside-nitriles (cyano-glycosides). Hydrolysis of starting materials in the blood medium and associated volume around physiologically active healthy and cancer cells, based on quantum-chemical semi-empirical methods, is considered. Objective:: Based on the fact that the cancer cell feeds primarily on carbohydrates, it is likely that organisms have adapted to take food containing nitrile glycosides and / or modified forms to counteract "external" bioactive activity. Cancers, for their part, have evolved to create conditions around their cells that eliminate their active apoptotic forms. This is far more appropriate for them than changing their entire enzyme regulation to counteract it. In this way, it protects itself and the gene sets and develops according to its instructions. Methods:: Derived pedestal that closely defines the processes of hydrolysis in the blood, the transfer of a specific molecular hydrolytic form to the cancer cell membrane and with the help of time-dependent density-functional quantum- chemical methods, its passage and the processes of re-hydrolysis within the cell itself, to forms causing chemical apoptosis of the cell - independent of its non-genetic set, which seeks to counteract the process. Results:: Used in oncology it could turn a cancer from a lethal to a chronic disease (such as diabetes). The causative agent and conditions for the development of the disease are not eliminated, but the amount of cancer cells could be kept low for a long time (even a lifetime). Conclusion:: The amide derivatives of nitrile glycosides exhibit anti-cancer activity, the cancer cell probably seeks to displace hydrolysis of these derivatives in a direction that would not pass through its cell membrane and the amide- carboxyl derivatives of nitrile glycosides could deliver extremely toxic compounds within the cancer cell itself and thus block and / or permanently damage its normal physiology.

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