Adaptive control in lubrication, adhesion, and hemostasis by Chitosan–Catechol–pNIPAM

2019 ◽  
Vol 7 (9) ◽  
pp. 3599-3608 ◽  
Author(s):  
Rongnian Xu ◽  
Shuanhong Ma ◽  
Yang Wu ◽  
Haeshin Lee ◽  
Feng Zhou ◽  
...  
Keyword(s):  
Adaptive Control ◽  
Sol Gel ◽  
Temperature Dependent ◽  
Wet Friction ◽  
Sol Gel Transition ◽  
Gel Transition

One kind of novel thermo-responsive polysaccharide wet adhesive of Chitosan–Catechol–pNIPAM is synthesized, which exhibits temperature dependent sol–gel transition, controllable wet friction/adhesiveness and instant hemostasis.

scholarly journals Drug-Loaded Biocompatible Nanocarriers Embedded in Poloxamer 407 Hydrogels as Therapeutic Formulations

Medicines ◽  
2018 ◽  
Vol 6 (1) ◽  
pp. 7 ◽  
Author(s):  
Elena Giuliano ◽  
Donatella Paolino ◽  
Massimo Fresta ◽  
Donato Cosco
Keyword(s):  
Controlled Release ◽  
Biological Fluid ◽  
Sol Gel ◽  
Three Dimensional ◽  
Delivery Systems ◽  
Poloxamer 407 ◽  
Temperature Dependent ◽  
Sol Gel Transition ◽  
Mixed Systems ◽  
Gel Transition

Hydrogels are three-dimensional networks of hydrophilic polymers able to absorb and retain a considerable amount of water or biological fluid while maintaining their structure. Among these, thermo-sensitive hydrogels, characterized by a temperature-dependent sol–gel transition, have been massively used as drug delivery systems for the controlled release of various bioactives. Poloxamer 407 (P407) is an ABA-type triblock copolymer with a center block of hydrophobic polypropylene oxide (PPO) between two hydrophilic polyethyleneoxide (PEO) lateral chains. Due to its unique thermo-reversible gelation properties, P407 has been widely investigated as a temperature-responsive material. The gelation phenomenon of P407 aqueous solutions is reversible and characterized by a sol–gel transition temperature. The nanoencapsulation of drugs within biocompatible delivery systems dispersed in P407 hydrogels is a strategy used to increase the local residence time of various bioactives at the injection site. In this mini-review, the state of the art of the most important mixed systems made up of colloidal carriers localized within a P407 hydrogel will be provided in order to illustrate the possibility of obtaining a controlled release of the entrapped drugs and an increase in their therapeutic efficacy as a function of the biomaterial used.

Sol-gel transition in silica alkaline solutions. A NMR study

1994 ◽  
Vol 91 ◽  
pp. 901-908 ◽  
Author(s):  
H Zanni ◽  
P Nieto ◽  
L Fernandez ◽  
R Couty ◽  
P Barret ◽  
...  
Keyword(s):  
Sol Gel ◽  
Alkaline Solutions ◽  
Nmr Study ◽  
Sol Gel Transition ◽  
Gel Transition

scholarly journals Synthesis of Nanogels: Current Trends and Future Outlook

Gels ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 36
Author(s):  
Emanuele Mauri ◽  
Sara Maria Giannitelli ◽  
Marcella Trombetta ◽  
Alberto Rainer
Keyword(s):  
3D Printing ◽  
Ad Hoc ◽  
Sol Gel ◽  
Controlled Polymerization ◽  
Current Trends ◽  
Chip Technology ◽  
Physico Chemical ◽  
Physical Interactions ◽  
Sol Gel Transition ◽  
Gel Transition

Nanogels represent an innovative platform for tunable drug release and targeted therapy in several biomedical applications, ranging from cancer to neurological disorders. The design of these nanocarriers is a pivotal topic investigated by the researchers over the years, with the aim to optimize the procedures and provide advanced nanomaterials. Chemical reactions, physical interactions and the developments of engineered devices are the three main areas explored to overcome the shortcomings of the traditional nanofabrication approaches. This review proposes a focus on the current techniques used in nanogel design, highlighting the upgrades in physico-chemical methodologies, microfluidics and 3D printing. Polymers and biomolecules can be combined to produce ad hoc nanonetworks according to the final curative aims, preserving the criteria of biocompatibility and biodegradability. Controlled polymerization, interfacial reactions, sol-gel transition, manipulation of the fluids at the nanoscale, lab-on-a-chip technology and 3D printing are the leading strategies to lean on in the next future and offer new solutions to the critical healthcare scenarios.

Analyzing the Effects of Silica Nanospheres on the Sol–Gel Transition Profile of Thermosensitive Hydrogels

Langmuir ◽  
2021 ◽  
Author(s):  
Lucas S. Ribeiro ◽  
Renata L. Sala ◽  
Leticia A. O. de Jesus ◽  
Sandra A. Cruz ◽  
Emerson R. Camargo
Keyword(s):  
Sol Gel ◽  
Silica Nanospheres ◽  
Thermosensitive Hydrogels ◽  
Sol Gel Transition ◽  
Gel Transition ◽  
Transition Profile
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