Reduced fibrous capsule formation at nano-engineered silicone surfaces via tantalum ion implantation

2019 ◽  
Vol 7 (7) ◽  
pp. 2907-2919 ◽  
Author(s):  
Cheonil Park ◽  
Si-Woo Lee ◽  
Jinyoung Kim ◽  
Eun-Ho Song ◽  
Hyun-Do Jung ◽  
...  
Keyword(s):  
Ion Implantation ◽  
Side Effect ◽  
Silicone Implant ◽  
Fibrous Capsule ◽  
Common Side Effect ◽  
Capsule Formation ◽  
Polymeric Implants ◽  
Fibrous Capsule Formation

Nano-engineered surface of silicone implant improves the biocompatibility and suppresses the fibrous capsule formation which is the most common side effect of polymeric implants.

scholarly journals High-strength and fibrous capsule–resistant zwitterionic elastomers

2021 ◽  
Vol 7 (1) ◽  
pp. eabc5442
Author(s):  
Dianyu Dong ◽  
Caroline Tsao ◽  
Hsiang-Chieh Hung ◽  
Fanglian Yao ◽  
Chenjue Tang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
High Strength ◽  
Design Principles ◽  
Fibrous Capsule ◽  
High Mechanical Strength ◽  
Capsule Formation ◽  
Locking Mechanism ◽  
Fibrous Capsule Formation

The high mechanical strength and long-term resistance to the fibrous capsule formation are two major challenges for implantable materials. Unfortunately, these two distinct properties do not come together and instead compromise each other. Here, we report a unique class of materials by integrating two weak zwitterionic hydrogels into an elastomer-like high-strength pure zwitterionic hydrogel via a “swelling” and “locking” mechanism. These zwitterionic-elastomeric-networked (ZEN) hydrogels are further shown to efficaciously resist the fibrous capsule formation upon implantation in mice for up to 1 year. Such materials with both high mechanical properties and long-term fibrous capsule resistance have never been achieved before. This work not only demonstrates a class of durable and fibrous capsule–resistant materials but also provides design principles for zwitterionic elastomeric hydrogels.

Effect of fibrous capsule formation on doxorubicin distribution in radiofrequency ablated rat livers

2004 ◽  
Vol 69A (3) ◽  
pp. 398-406 ◽  
Author(s):  
Elvin Blanco ◽  
Feng Qian ◽  
Brent Weinberg ◽  
Nicholas Stowe ◽  
James M. Anderson ◽  
...  
Keyword(s):  
Fibrous Capsule ◽  
Capsule Formation ◽  
Rat Livers ◽  
Fibrous Capsule Formation
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