Analysis of hazardous chemicals by “stand alone” drift tube ion mobility spectrometry: a review

2020 ◽  
Vol 12 (9) ◽  
pp. 1163-1181 ◽  
Author(s):  
S. Armenta ◽  
F. A. Esteve-Turrillas ◽  
M. Alcalà
Keyword(s):  
Electric Field ◽  
Gas Phase ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Drift Tube ◽  
Hazardous Chemicals ◽  
Ion Separation ◽  
Gas Phase Ion

Drift tube-ion mobility spectrometry (DT-IMS) is a widely used technique for the determination of semi-volatile hazardous chemicals based on gas phase ion separation under an electric field by differences in ion mobilities.

Determination of Gas-Phase Ion Mobility Coefficients Using Voltage Sweep Multiplexing

2019 ◽  
Vol 30 (6) ◽  
pp. 977-986 ◽  
Author(s):  
Tobias Reinecke ◽  
Austen L. Davis ◽  
Brian H. Clowers
Keyword(s):  
Gas Phase ◽  
Ion Mobility ◽  
Voltage Sweep ◽  
Gas Phase Ion

scholarly journals Ion Mobility–Mass Spectrometry for Bioanalysis

Separations ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 33
Author(s):  
Xavier Garcia ◽  
Maria del Mar Sabaté ◽  
Jorge Aubets ◽  
Josep Maria Jansat ◽  
Sonia Sentellas
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Biological Samples ◽  
Ion Mobility Mass Spectrometry ◽  
Exogenous Compounds ◽  
Analytical Separation

This paper aims to cover the main strategies based on ion mobility spectrometry (IMS) for the analysis of biological samples. The determination of endogenous and exogenous compounds in such samples is important for the understanding of the health status of individuals. For this reason, the development of new approaches that can be complementary to the ones already established (mainly based on liquid chromatography coupled to mass spectrometry) is welcomed. In this regard, ion mobility spectrometry has appeared in the analytical scenario as a powerful technique for the separation and characterization of compounds based on their mobility. IMS has been used in several areas taking advantage of its orthogonality with other analytical separation techniques, such as liquid chromatography, gas chromatography, capillary electrophoresis, or supercritical fluid chromatography. Bioanalysis is not one of the areas where IMS has been more extensively applied. However, over the last years, the interest in using this approach for the analysis of biological samples has clearly increased. This paper introduces the reader to the principles controlling the separation in IMS and reviews recent applications using this technique in the field of bioanalysis.

scholarly journals Rapid determination of N-methylpyrrolidine in cefepime by combining direct infusion electrospray ionisation-time-of-flight mass spectrometry with field asymmetric waveform ion mobility spectrometry

2015 ◽  
Vol 7 (1) ◽  
pp. 34-39 ◽  
Author(s):  
Robert W. Smith ◽  
Lisa B. Cox ◽  
Aswandi Yudin ◽  
James C. Reynolds ◽  
Mark Powell ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Rapid Determination ◽  
Time Of Flight ◽  
Asymmetric Waveform ◽  
Direct Infusion ◽  
Electrospray Ionisation ◽  
Flight Mass Spectrometry

FAIMS separation prior to mass spectrometry enables selective transmission of NMP in cefepime without interference from NMP formed by in-source CID.

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