An anti-influenza virus activity-calibrated chemical standardization approach for quality evaluation of indigo naturalis

2019 ◽  
Vol 11 (37) ◽  
pp. 4719-4726 ◽  
Author(s):  
Ting Zhang ◽  
Hao-zhou Huang ◽  
Run-chun Xu ◽  
Jia-bo Wang ◽  
Ming Yang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Herbal Medicine ◽  
Clinical Application ◽  
Industrial Development ◽  
Quality Evaluation ◽  
Virus Activity ◽  
Indigo Naturalis

The quality evaluation of herbal medicine is the basis of its clinical application and industrial development.

Quality evaluation of fingerprints of herbal medicine with chromatographic data

2004 ◽  
Vol 514 (1) ◽  
pp. 69-77 ◽  
Author(s):  
Bo-Yan Li ◽  
Yun Hu ◽  
Yi-Zeng Liang ◽  
Pei-Shan Xie ◽  
Yi-Ping Du
Keyword(s):  
Herbal Medicine ◽  
Quality Evaluation ◽  
Chromatographic Data

scholarly journals Influenza vaccine failure in the tropics: a retrospective cohort study of waning effectiveness

2020 ◽  
Vol 148 ◽  
Author(s):  
B. E. Young ◽  
T. M. Mak ◽  
L. W. Ang ◽  
S. Sadarangani ◽  
H. J. Ho ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Cohort Study ◽  
Influenza Vaccine ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Influenza Infection ◽  
Winter Season ◽  
Temperate Climate ◽  
Vaccine Failure ◽  
Virus Activity

Abstract Influenza vaccine effectiveness (VE) wanes over the course of a temperate climate winter season but little data are available from tropical countries with year-round influenza virus activity. In Singapore, a retrospective cohort study of adults vaccinated from 2013 to 2017 was conducted. Influenza vaccine failure was defined as hospital admission with polymerase chain reaction-confirmed influenza infection 2–49 weeks after vaccination. Relative VE was calculated by splitting the follow-up period into 8-week episodes (Lexis expansion) and the odds of influenza infection in the first 8-week period after vaccination (weeks 2–9) compared with subsequent 8-week periods using multivariable logistic regression adjusting for patient factors and influenza virus activity. Records of 19 298 influenza vaccinations were analysed with 617 (3.2%) influenza infections. Relative VE was stable for the first 26 weeks post-vaccination, but then declined for all three influenza types/subtypes to 69% at weeks 42–49 (95% confidence interval (CI) 52–92%, P = 0.011). VE declined fastest in older adults, in individuals with chronic pulmonary disease and in those who had been previously vaccinated within the last 2 years. Vaccine failure was significantly associated with a change in recommended vaccine strains between vaccination and observation period (adjusted odds ratio 1.26, 95% CI 1.06–1.50, P = 0.010).

ChemInform Abstract: ANTIVIRAL COMPOUNDS PART 4, SYNTHESIS AND ANTI-INFLUENZA VIRUS ACTIVITY OF AMIDINOHYDRAZONES

1975 ◽  
Vol 6 (8) ◽  
pp. no-no
Author(s):  
T. NISHIMURA ◽  
C. YAMAZAKI ◽  
H. TOKU ◽  
S. YOSHII ◽  
K. HASEGAWA ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Antiviral Compounds ◽  
Virus Activity

scholarly journals Inhibition of H1N1 influenza virus by selenium nanoparticles loaded with zanamivir through p38 and JNK signaling pathways

RSC Advances ◽  
2017 ◽  
Vol 7 (56) ◽  
pp. 35290-35296 ◽  
Author(s):  
Zhengfang Lin ◽  
Yinghua Li ◽  
Min Guo ◽  
Misi Xiao ◽  
Changbing Wang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Signaling Pathways ◽  
Clinical Application ◽  
Influenza Virus Infection ◽  
Aqueous Solubility ◽  
H1n1 Influenza ◽  
Solubility Limit ◽  
H1n1 Influenza Virus ◽  
Jnk Signaling

Zanamivir is an effective drug for influenza virus infection, but strong molecular polarity and aqueous solubility limit its clinical application.

scholarly journals Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of Ailanthus altissima

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5679
Author(s):  
Qing-Wei Tan ◽  
Jian-Cheng Ni ◽  
Jian-Ting Shi ◽  
Jian-Xuan Zhu ◽  
Qi-Jian Chen
Keyword(s):  
Data Analysis ◽  
Herbal Medicine ◽  
Inhibitory Concentration ◽  
Biological Activities ◽  
Virus Multiplication ◽  
Ailanthus Altissima ◽  
Inhibitory Effects ◽  
Traditional Herbal Medicine ◽  
Virus Activity ◽  
Ic50 Values

Phytochemistry investigations on Ailanthus altissima (Mill.) Swingle, a Simaroubaceae plant that is recognized as a traditional herbal medicine, have afforded various natural products, among which C20 quassinoid is the most attractive for their significant and diverse pharmacological and biological activities. Our continuous study has led to the isolation of two novel quassinoid glycosides, named chuglycosides J and K, together with fourteen known lignans from the samara of A. altissima. The new structures were elucidated based on comprehensive spectra data analysis. All of the compounds were evaluated for their anti-tobacco mosaic virus activity, among which chuglycosides J and K exhibited inhibitory effects against the virus multiplication with half maximal inhibitory concentration (IC50) values of 56.21 ± 1.86 and 137.74 ± 3.57 μM, respectively.

A novel isocoumarin with anti-influenza virus activity from Strobilanthes cusia

Fitoterapia ◽  
2015 ◽  
Vol 107 ◽  
pp. 60-62 ◽  
Author(s):  
Wei Gu ◽  
Wei Wang ◽  
Xiao-nian Li ◽  
Yu Zhang ◽  
Li-ping Wang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Activity
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