ForSDAT: an automated platform for analyzing force spectroscopy measurements

2019 ◽  
Vol 11 (37) ◽  
pp. 4709-4718 ◽  
Author(s):  
Tal Duanis-Assaf ◽  
Yair Razvag ◽  
Meital Reches
Keyword(s):  
Protein Folding ◽  
Data Analysis ◽  
Atomic Force Microscope ◽  
Single Molecule ◽  
Force Spectroscopy ◽  
Single Molecule Force Spectroscopy ◽  
Atomic Force ◽  
Receptor Interactions ◽  
Automated Data Analysis ◽  
Automated Platform

Single molecule force spectroscopy (SMFS) using an atomic force microscope is a common method in the study of ligand–receptor interactions, adhesion events and protein folding. ForSDAT is a platform for automated data analysis of SMFS data.

Atomic force microscope-based single-molecule force spectroscopy of RNA unfolding

2011 ◽  
Vol 414 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Hans A. Heus ◽  
Elias M. Puchner ◽  
Aafke J. van Vugt-Jonker ◽  
Julia L. Zimmermann ◽  
Hermann E. Gaub
Keyword(s):  
Atomic Force Microscope ◽  
Single Molecule ◽  
Force Spectroscopy ◽  
Single Molecule Force Spectroscopy ◽  
Atomic Force

scholarly journals A Tiny Toolbox

1997 ◽  
Vol 5 (7) ◽  
pp. 3-7
Author(s):  
Stephen W. Carmichael
Keyword(s):  
Atomic Force Microscope ◽  
Single Molecule ◽  
Recent Article ◽  
Single Molecules ◽  
Force Spectroscopy ◽  
Atomic Level ◽  
Single Molecule Force Spectroscopy ◽  
Binding Force ◽  
Atomic Force

A recent article by Matthias Rief, Filipp Oesterhelt. Berthold Heymann, and Hermann Gaub concluded with this sentence: "Single molecule force spectroscopy by AFM has proven to be a powerful addition to the nanoscopic piconewton toolbox," Everything about that conclusion is tiny. Clearly, the atomic force microscope (AFM) has given us a tool to examine structure at or near the atomic level. Earlier work from Gaub's laboratory, reviewed in this column, demonstrated that the AFM could directly measure the binding force between single molecules of biotin and avidin. This established that the AFM could be used as a tool to measure forces, not just observe structure. Their most recent experiments has added to this tiny toolbox.

SpyTag/SpyCatcher Tether as a Fingerprint and Force Marker for Single-Molecule Force Spectroscopy Experiments

Nanoscale ◽  
2021 ◽  
Author(s):  
Zilong Guo ◽  
Haiyan Hong ◽  
Hao Sun ◽  
Xiaofeng Zhang ◽  
Chen-Xu Wu ◽  
...  
Keyword(s):  
Protein Folding ◽  
Single Molecule ◽  
Force Spectroscopy ◽  
Single Molecule Force Spectroscopy ◽  
Receptor Interactions ◽  
Folding Dynamics

Single molecule force spectroscopy has emerged as a powerful tool to study protein folding dynamics, ligand-receptor interactions, and various mechanobiological processes. High force precision does not necessarily lead to high...

scholarly journals Minimizing Pulling Geometry Errors in Atomic Force Microscope Single Molecule Force Spectroscopy

2008 ◽  
Vol 95 (8) ◽  
pp. 3991-3998 ◽  
Author(s):  
Monica Rivera ◽  
Whasil Lee ◽  
Changhong Ke ◽  
Piotr E. Marszalek ◽  
Daniel G. Cole ◽  
...  
Keyword(s):  
Atomic Force Microscope ◽  
Single Molecule ◽  
Force Spectroscopy ◽  
Single Molecule Force Spectroscopy ◽  
Atomic Force

scholarly journals Optimizing 1-μs-Resolution Single-Molecule Force Spectroscopy on a Commercial Atomic Force Microscope

Nano Letters ◽  
2015 ◽  
Vol 15 (10) ◽  
pp. 7091-7098 ◽  
Author(s):  
Devin T. Edwards ◽  
Jaevyn K. Faulk ◽  
Aric W. Sanders ◽  
Matthew S. Bull ◽  
Robert Walder ◽  
...  
Keyword(s):  
Atomic Force Microscope ◽  
Single Molecule ◽  
Force Spectroscopy ◽  
Single Molecule Force Spectroscopy ◽  
Atomic Force ◽  
Resolution Single

scholarly journals Dynamics of breaking intermolecular bonds in high-speed force spectroscopy

Nanoscale ◽  
2018 ◽  
Vol 10 (36) ◽  
pp. 17112-17116 ◽  
Author(s):  
Manuel R. Uhlig ◽  
Carlos A. Amo ◽  
Ricardo Garcia
Keyword(s):  
Atomic Force Microscope ◽  
Intermolecular Interactions ◽  
Single Molecule ◽  
High Speed ◽  
Force Spectroscopy ◽  
Single Molecule Force Spectroscopy ◽  
Atomic Force

Atomic force microscope based single-molecule force spectroscopy provides a description of a variety of intermolecular interactions such as those occurring between receptor molecules and their ligands.

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