Developing a new and simple natural deep eutectic solvent based ultrasonic-assisted microextraction procedure for determination and preconcentration of As and Se from rice samples

2019 ◽  
Vol 11 (27) ◽  
pp. 3429-3438 ◽  
Author(s):  
Adil Elik ◽  
Ahmet Demirbas ◽  
Nail Altunay
Keyword(s):  
Deep Eutectic Solvent ◽  
Ultrasonic Assisted ◽  
Rice Samples ◽  
Natural Deep Eutectic Solvent ◽  
Optimization Of Variables

Optimization of variables affecting the NADES-UAME procedure.

scholarly journals ULTRASONIC-ASSISTED EXTRACTION USING A BETAINE-BASED NATURAL DEEP EUTECTIC SOLVENT FOR RESVERATROL EXTRACTION FROM MELINJO (GNETUM GNEMON) SEEDS

2020 ◽  
pp. 26-31
Author(s):  
WIDYA DWI ARYATI ◽  
KHUSNA MILLATI AZKA ◽  
ABDUL MUN’IM
Keyword(s):  
Lactic Acid ◽  
High Performance ◽  
Deep Eutectic Solvent ◽  
High Water Content ◽  
Solvent Ratio ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Gnetum Gnemon ◽  
Ultrasonic Assisted Extraction ◽  
Natural Deep Eutectic Solvent

Objective: Melinjo (Gnetum gnemon L.) seeds are known to contain resveratrol, which are classified as a phenolic compound of the stilbenoid. Melinjoseeds have high water content, making them unstable to be stored for prolonged periods with open packaging at room temperature. The present studyaimed to explore the use of ultrasonic-assisted extraction with a betaine-based natural deep eutectic solvent (NADES) for resveratrol extraction fromirradiated melinjo seeds.Methods: The best betaine-based NADES component was identified among betaine-urea, betaine-lactic acid, and betaine-malic acid. Optimization ofextraction methods was performed using the best NADES and extraction variables such as time of extraction, water percentage, and sample: solventratio. The outcome of extraction was evaluated by measuring resveratrol content using high-performance liquid chromatography and the results wereanalyzed using response surface methodology.Results: The best betaine-based NADES was found to be betaine-lactic acid, yielding a resveratrol content of 0.3344 mg/g powder. The optimumextraction was achieved in 10 min with 60% water and a sample: solvent ratio of 1:10, yielding a resveratrol content of 0.227 mg/g powder.Conclusion: Betaine-based NADES can be purposed as an alternative solvent for resveratrol extraction from irradiated melinjo seeds.

Recovery of metabolites from natural deep eutectic solvent matrices by countercurrent separation

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
Y Liu ◽  
J Garzon ◽  
JB Friesen ◽  
DC Lankin ◽  
JB McAlpine ◽  
...  
Keyword(s):  
Deep Eutectic Solvent ◽  
Natural Deep Eutectic Solvent

scholarly journals Amino Acids as the Potential Co-Former for Co-Crystal Development: A Review

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3279
Author(s):  
Ilma Nugrahani ◽  
Maria Anabella Jessica
Keyword(s):  
Amino Acids ◽  
Physicochemical Properties ◽  
Deep Eutectic Solvent ◽  
Strong Interactions ◽  
Green Method ◽  
Pharmaceutical Ingredients ◽  
Gastrointestinal Fluid ◽  
Non Covalent Interactions ◽  
Natural Deep Eutectic Solvent ◽  
Covalent Interactions

Co-crystals are one of the most popular ways to modify the physicochemical properties of active pharmaceutical ingredients (API) without changing pharmacological activity through non-covalent interactions with one or more co-formers. A “green method” has recently prompted many researchers to develop solvent-free techniques or minimize solvents for arranging the eco-friendlier process of co-crystallization. Researchers have also been looking for less-risk co-formers that produce the desired API’s physicochemical properties. This review purposed to collect the report studies of amino acids as the safe co-former and explored their advantages. Structurally, amino acids are promising co-former candidates as they have functional groups that can form hydrogen bonds and increase stability through zwitterionic moieties, which support strong interactions. The co-crystals and deep eutectic solvent yielded from this natural compound have been proven to improve pharmaceutical performance. For example, l-glutamine could reduce the side effects of mesalamine through an acid-base stabilizing effect in the gastrointestinal fluid. In addition, some amino acids, especially l-proline, enhances API’s solubility and absorption in its natural deep eutectic solvent and co-crystals systems. Moreover, some ionic co-crystals of amino acids have also been designed to increase chiral resolution. Therefore, amino acids are safe potential co-formers, which are suitable for improving the physicochemical properties of API and prospective to be developed further in the dosage formula and solid-state syntheses.

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