scholarly journals SERS-based sandwich bioassay protocol of miRNA-21 using Au@Ag core–shell nanoparticles and a Ag/TiO2 nanowires substrate

2019 ◽  
Vol 11 (23) ◽  
pp. 2960-2968 ◽  
Author(s):  
Le Peng ◽  
Jun Zhou ◽  
Zhaoheng Liang ◽  
Yaping Zhang ◽  
Lucia Petti ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Sandwich Structure ◽  
High Sensitivity ◽  
Core Shell ◽  
Tio2 Nanowires ◽  
Shell Nanoparticles ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Core Shell Nanoparticles

Based on surface-enhanced Raman scattering (SERS) technology, Au@Ag@4MBA@5′-NH2-ssDNA probes and a Ag/TiO2@3′-NH2-ssDNA substrate were prepared and constructed into a sandwich structure to develop a high sensitivity bioassay of miRNA-21.

scholarly journals Performance Improving Method of Aligned Silver Nanorod by Grafting Au@Ag Core–Shell Nanoparticles for Surface-Enhanced Raman Scattering

NANO ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. 1750131 ◽  
Author(s):  
Jian Chen ◽  
Peitao Dong ◽  
Chaoguang Wang ◽  
Chenyu Zhang ◽  
Junfeng Wang ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Surface Enhanced Raman Scattering ◽  
Core Shell ◽  
Sers Substrate ◽  
Shell Nanoparticles ◽  
Simple Method ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Core Shell Nanoparticles

A simple method for improving surface-enhanced Raman scattering (SERS) performance of aligned silver nanorod (Ag NR) array was investigated. This method was to construct a kind of hybrid substrate by grafting Au@Ag core–shell nanoparticles (NPs) into Ag NR array using poly(2-vinylphridine) (P2VPy) as a bridging agent. The hybrid substrate yielded excellent SERS performance as its detection limit improved from 10[Formula: see text] M to 10[Formula: see text] M using trans-1,2-bis(4-pyridyl)ethylene (BPE) as probe molecule, which was increased by two orders of magnitude compared with Ag NR array substrate. The significant improvement of SERS performance of Ag NR arrays was attributed to the addition of Au@Ag core–shell NPs. As a result of surface plasmon resonance generated by the interaction of electromagnetic (EM) (IAEM) filed between NP and NR structures, increasing hotspots were found at the connections of NPs and NRs, the gaps of adjacent rods, and the gaps of two particles consequently. These results were validated by the finite difference time domain (FDTD) calculation. Besides, hybrid substrate shows good performance in stability and reproducibility. The proposed method was simple and robust, which promoted SERS performance of Ag NR array effectively, showing great potential in the application of SERS substrate fabrication and SERS-based bio-chemical sensing.

Aptamer based surface enhanced Raman scattering detection of adenosine using various core sizes of Au–Ag core–shell nanoparticles

RSC Advances ◽  
2014 ◽  
Vol 4 (50) ◽  
pp. 26251-26257 ◽  
Author(s):  
Fu-Hsiang Ko ◽  
Yu-Cheng Chang
Keyword(s):  
Raman Scattering ◽  
Core Shell ◽  
Silicon Substrates ◽  
Shell Nanoparticles ◽  
Au Nps ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Core Shell Nanoparticles ◽  
Growth Approach

The combination of the varied sizes of Au NPs and seeding growth approach can be exploited to control the sizes of Au–Ag core–shell NPs. The silicon substrates with self-assembled Au–Ag core–shell NPs can be used to detect adenosine by a structures-switch aptamer.

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