An ionic liquid composed of purely functional sensing molecules: a colorimetrically calcium responsive ionic liquid

The Analyst ◽  
2019 ◽  
Vol 144 (23) ◽  
pp. 6858-6861 ◽  
Author(s):  
Yusuke Niwa ◽  
Tatsumi Mizuta ◽  
Kenji Sueyoshi ◽  
Tatsuro Endo ◽  
Hideaki Hisamoto
Keyword(s):  
Ionic Liquid ◽  
Calcium Ionophore ◽  
Cationic Dye ◽  
Highly Sensitive ◽  
Calcium Detection ◽  
First Time

A new unique ionic liquid consisting of two purely functional sensing molecules, an anionic calcium ionophore and a cationic dye, was developed for the first time, and highly sensitive calcium detection was achieved.

Mapping the “Extra Solvent Power, ESP” of Ionic Liquids for Monomers, Polymers and Globular Nanoparticles

2017 ◽  
Author(s):  
Jose A. Pomposo
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Linear Polymers ◽  
Green Solvents ◽  
Ionic Polymers ◽  
First Time ◽  
Solvent Power

Understanding the miscibility behavior of ionic liquid (IL) / monomer, IL / polymer and IL / nanoparticle mixtures is critical for the use of ILs as green solvents in polymerization processes, and to rationalize recent observations concerning the superior solubility of some proteins in ILs when compared to standard solvents. In this work, the most relevant results obtained in terms of a three-component Flory-Huggins theory concerning the “Extra Solvent Power, ESP” of ILs when compared to traditional non-ionic solvents for monomeric solutes (case I), linear polymers (case II) and globular nanoparticles (case III) are presented. Moreover, useful ESP maps are drawn for the first time for IL mixtures corresponding to case I, II and III. Finally, a potential pathway to improve the miscibility of non-ionic polymers in ILs is also proposed.

Intramolecular photoinitiator induced atom transfer radical polymerization for electrochemical DNA detection

The Analyst ◽  
2020 ◽  
Vol 145 (3) ◽  
pp. 858-864
Author(s):  
Ligang Ma ◽  
Qianrui Liu ◽  
Lihe Jian ◽  
Shan Ye ◽  
Xiaoke Zheng ◽  
...  
Keyword(s):  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Electrochemical Biosensor ◽  
Dna Detection ◽  
Atom Transfer ◽  
Highly Sensitive ◽  
Electrochemical Dna Detection ◽  
First Time

A novel electrochemical biosensor was reported for the first time to achieve highly sensitive DNA detection based on photoinduced atom transfer radical polymerization (photoATRP).

scholarly journals Analysis of free and protein-bound nitrotyrosine in human plasma by a gas chromatography/mass spectrometry method that avoids nitration artifacts

2000 ◽  
Vol 345 (3) ◽  
pp. 453-458 ◽  
Author(s):  
Matthew T. FROST ◽  
Barry HALLIWELL ◽  
Kevin P. MOORE
Keyword(s):  
Reactive Nitrogen Species ◽  
Plasma Proteins ◽  
Biological Fluids ◽  
Plasma Concentrations ◽  
Normal Subjects ◽  
Gas Chromatography Mass Spectrometry ◽  
Highly Sensitive ◽  
Acidic Conditions ◽  
First Time

Measurement of nitrotyrosine in biological fluids and tissues is increasingly being used to monitor the production of reactive nitrogen species in vivo. The detection of nitrotyrosine in vivo has been reported with the use of a variety of methods including immunoassay, HPLC and GLC/MS. The validity of HPLC and immunoassays have been questioned with regard to their selectivity and sensitivity limits. In principle, the measurement of nitrotyrosine by GLC/MS permits a highly specific, highly sensitive and fully quantitative assay. The nitration of tyrosine under acidic conditions in the presence of nitrite is well documented. Derivatization for the full quantification of nitrotyrosine by using GLC/MS can lead to the artifactual nitration of tyrosine if performed under acidic conditions in the presence of nitrite. We describe a novel alkaline method for the hydrolysis and derivatization of nitrotyrosine and tyrosine, and demonstrate its applicability to the measurement of plasma concentrations of both free and protein-bound nitrotyrosine and tyrosine. A detection limit of 1 pg for nitrotyrosine and 100 pg for tyrosine has been achieved. Our method allows, for the first time, the analysis of free and protein-bound nitrotyrosine and tyrosine in biological samples. The plasma concentrations (means±S.E.M.) of free tyrosine and nitrotyrosine in eight normal subjects were 12±0.6 μg/ml and 14±0.7 ng/ml respectively. Plasma proteins contained tyrosine and nitrotyrosine at 60.7±1.7 μg/mg and 2.7±0.4 ng/mg respectively.

scholarly journals The growth of interest for astronomical X-ray polarimetry

2018 ◽  
Author(s):  
Frédéric Marin
Keyword(s):  
Quantitative Assessment ◽  
Supernova Remnant ◽  
Scientific Literature ◽  
High Energy ◽  
X Ray ◽  
Highly Sensitive ◽  
In The Beginning ◽  
First Time

Astronomical X-ray polarimetry was first explored in the end of the 60's by pioneering rocket instruments. The craze arising from the first discoveries on stellar and supernova remnant X-ray polarization led to the addition of X-ray polarimeters on-board of early satellites. Unfortunately, the inadequacy of the diffraction and scattering technologies required to measure polarization with respect to the constraints driven by X-ray mirrors and detectors, coupled to long integration times, slowed down the field for almost 40 years. Thanks to the development of new, highly sensitive, compact X-ray polarimeters in the beginning of the 2000's, the possibility to observe astronomical X-ray polarization is rising again and scientists are now ready to explore the high energy sky thanks to modern X-ray polarimeters. In the forthcoming years, several X-ray missions (both rockets, balloons and satellites) will open a new observational windows. A wind of renewal blows over the area of X-ray polarimetry and this paper presents for the first time a quantitative assessment, all based on scientific literature, of the growth of interest for astronomical X-ray polarimetry.

Brønsted acidic ionic liquid-catalyzed dehydrative formation of isosorbide from sorbitol: introduction of a continuous process

2017 ◽  
Vol 7 (10) ◽  
pp. 2065-2073 ◽  
Author(s):  
Jie Deng ◽  
Bao-Hua Xu ◽  
Yao-Feng Wang ◽  
Xian-En Mo ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Continuous Process ◽  
Efficient Synthesis ◽  
Acidic Ionic Liquid ◽  
Highly Efficient ◽  
Brønsted Acidic Ionic Liquid ◽  
Acidic Ionic Liquids ◽  
First Time

A highly efficient synthesis of isosorbide from sorbitol was developed using Brønsted acidic ionic liquids (BILs) as the catalyst for the first time.

scholarly journals Highly sensitive p-type 4H-SiC van der Pauw sensor

RSC Advances ◽  
2018 ◽  
Vol 8 (6) ◽  
pp. 3009-3013 ◽  
Author(s):  
Tuan-Khoa Nguyen ◽  
Hoang-Phuong Phan ◽  
Jisheng Han ◽  
Toan Dinh ◽  
Abu Riduan Md Foisal ◽  
...  
Keyword(s):  
Silicon Carbide ◽  
Strain Sensor ◽  
Highly Sensitive ◽  
Van Der Pauw ◽  
P Type ◽  
First Time

This paper presents for the first time a p-type 4H silicon carbide (4H-SiC) van der Pauw strain sensor by utilizing the strain induced effect in four-terminal devices.

The appearance of glycoconjugates associated with cortical granule release during mouse fertilization

Development ◽  
1988 ◽  
Vol 102 (3) ◽  
pp. 595-604 ◽  
Author(s):  
S.H. Lee ◽  
K.K. Ahuja ◽  
D.J. Gilburt ◽  
D.G. Whittingham
Keyword(s):  
Calcium Ionophore ◽  
Calcium Ionophore A23187 ◽  
Meiotic Spindle ◽  
Cortical Granule ◽  
Ionophore A23187 ◽  
Perivitelline Space ◽  
Cell Stage ◽  
Artificial Activation ◽  
First Time ◽  
Kinetics Of

For the first time we have shown with appropriately labelled lectins that fucosyl- and sialyl-rich glycoconjugates are released into the perivitelline space of the mouse oocyte after activation by the fertilizing spermatozoon or artificial activation by the calcium ionophore A23187 or ethanol. The glycoconjugates show a punctate distribution over the oocyte surface except for the microvilli-free area overlying the second meiotic spindle from which they are absent. Their appearance in the perivitelline space is associated with the release of the cortical granule suggesting that they represent part of the cortical granule exudate. Soon after the glycoconjugates appear, they begin to aggregate. The process continues until the beginning of cytokinesis at first cleavage when a single large aggregate is found within the cleavage furrow. Most of the labelled glycoconjugates disappear by the late 2-cell stage and no evidence was found for their presence during the later preimplantation period. This technique is suitable for monitoring the kinetics of the cortical reaction in mammalian oocytes and investigating the importance of the glycoconjugates in early preimplantation period.

Revealing the unseen: the organizer region of the nucleolus

2001 ◽  
Vol 114 (17) ◽  
pp. 3199-3205 ◽  
Author(s):  
Marco Biggiogera ◽  
Manuela Malatesta ◽  
Sousan Abolhassani-Dadras ◽  
François Amalric ◽  
Lawrence I. Rothblum ◽  
...  
Keyword(s):  
Inner Core ◽  
Organizer Region ◽  
Exact Distribution ◽  
Dense Fibrillar Component ◽  
Fibrillar Center ◽  
Energy Filtering ◽  
Dna And Rna ◽  
Highly Sensitive ◽  
Fibrillar Component ◽  
First Time

We carried out a high-resolution ultrastructural analysis of the nucleolus in mouse P815 cells by combining specific DNA and RNA staining, anti-fibrillarin immunolabeling, contrast enhancement by energy filtering TEM and phosphorus mapping by ESI to visualize nucleic acids. We demonstrated that specifically contrasted DNA, fibrillarin and phosphorus overlap within the nucleolar dense fibrillar component. Moreover, we describe a ‘DNA cloud’ consisting of an inner core of DNA fibers (fibrillar center) and a periphery made of extremely thin fibrils overlapping the anti-fibrillarin immunolabeling (dense fibrillar component). This highly sensitive approach has allowed us to demonstrate, for the first time, the exact distribution of DNA within the decondensed interphase counterpart of the NOR, which includes both the fibrillar center and the dense fibrillar component.

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