NanoMIP-based approach for the suppression of interference signals in electrochemical sensors

The Analyst ◽  
2019 ◽  
Vol 144 (24) ◽  
pp. 7290-7295
Author(s):  
Riccardo Rapini ◽  
Francesco Canfarotta ◽  
Elisabetta Mazzotta ◽  
Cosimino Malitesta ◽  
Giovanna Marrazza ◽  
...  
Keyword(s):  
Electrochemical Detection ◽  
Electrochemical Sensors ◽  
Molecularly Imprinted ◽  
Interference Signals ◽  
Masking Agents ◽  
Molecularly Imprinted Nanoparticles ◽  
Target Analyte

Herein, we describe the use of molecularly imprinted nanoparticles (nanoMIPs) as sequestering (masking) agents, to suppress the signal coming from interfering molecules and facilitate the electrochemical detection of the target analyte.

scholarly journals A simple approach to prepare fluorescent molecularly imprinted nanoparticles

RSC Advances ◽  
2021 ◽  
Vol 11 (13) ◽  
pp. 7732-7737
Author(s):  
Fenying Wang ◽  
Dan Wang ◽  
Tingting Wang ◽  
Yu Jin ◽  
Baoping Ling ◽  
...  
Keyword(s):  
High Performance ◽  
Low Cost ◽  
Sol Gel ◽  
Silica Sol ◽  
Simple Approach ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Low Toxicity ◽  
Good Biocompatibility ◽  
Molecularly Imprinted Nanoparticles

Fluorescent molecularly imprinted polymer (FMIP) gains great attention in many fields due to their low cost, good biocompatibility and low toxicity. Here, a high-performance FMIP was prepared based on the autocatalytic silica sol–gel reaction.

scholarly journals Molecularly Imprinted Polymers Combined with Electrochemical Sensors for Food Contaminants Analysis

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4607
Author(s):  
Dounia Elfadil ◽  
Abderrahman Lamaoui ◽  
Flavio Della Pelle ◽  
Aziz Amine ◽  
Dario Compagnone
Keyword(s):  
Food Safety ◽  
Molecularly Imprinted Polymers ◽  
Electrochemical Sensors ◽  
Low Cost ◽  
Electrochemical Analysis ◽  
Ease Of Use ◽  
Electrochemical Sensing ◽  
Food Contaminants ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Detection of relevant contaminants using screening approaches is a key issue to ensure food safety and respect for the regulatory limits established. Electrochemical sensors present several advantages such as rapidity; ease of use; possibility of on-site analysis and low cost. The lack of selectivity for electrochemical sensors working in complex samples as food may be overcome by coupling them with molecularly imprinted polymers (MIPs). MIPs are synthetic materials that mimic biological receptors and are produced by the polymerization of functional monomers in presence of a target analyte. This paper critically reviews and discusses the recent progress in MIP-based electrochemical sensors for food safety. A brief introduction on MIPs and electrochemical sensors is given; followed by a discussion of the recent achievements for various MIPs-based electrochemical sensors for food contaminants analysis. Both electropolymerization and chemical synthesis of MIP-based electrochemical sensing are discussed as well as the relevant applications of MIPs used in sample preparation and then coupled to electrochemical analysis. Future perspectives and challenges have been eventually given.

scholarly journals Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

Materials ◽  
2021 ◽  
Vol 14 (7) ◽  
pp. 1668
Author(s):  
Bronach Healy ◽  
Tian Yu ◽  
Daniele C. da Silva Alves ◽  
Cynthia Okeke ◽  
Carmel B. Breslin
Keyword(s):  
Chiral Recognition ◽  
Electrochemical Sensors ◽  
Intramolecular Interactions ◽  
Robust Methods ◽  
Short Introduction ◽  
Reduced Graphene ◽  
Target Analytes ◽  
Recognition Systems ◽  
Covalent Interactions ◽  
Target Analyte

Supramolecular chemistry, although focused mainly on noncovalent intermolecular and intramolecular interactions, which are considerably weaker than covalent interactions, can be employed to fabricate sensors with a remarkable affinity for a target analyte. In this review the development of cyclodextrin-based electrochemical sensors is described and discussed. Following a short introduction to the general properties of cyclodextrins and their ability to form inclusion complexes, the cyclodextrin-based sensors are introduced. This includes the combination of cyclodextrins with reduced graphene oxide, carbon nanotubes, conducting polymers, enzymes and aptamers, and electropolymerized cyclodextrin films. The applications of these materials as chiral recognition agents and biosensors and in the electrochemical detection of environmental contaminants, biomolecules and amino acids, drugs and flavonoids are reviewed and compared. Based on the papers reviewed, it is clear that cyclodextrins are promising molecular recognition agents in the creation of electrochemical sensors, chiral sensors, and biosensors. Moreover, they have been combined with a host of materials to enhance the detection of the target analytes. Nevertheless, challenges remain, including the development of more robust methods for the integration of cyclodextrins into the sensing unit.

scholarly journals Molecularly imprinted polymer-based electrochemical sensors for biopolymers

2019 ◽  
Vol 14 ◽  
pp. 53-59 ◽  
Author(s):  
Frieder W. Scheller ◽  
Xiaorong Zhang ◽  
Aysu Yarman ◽  
Ulla Wollenberger ◽  
Róbert E. Gyurcsányi
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Electrochemical Sensors ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

scholarly journals Multiplexed Detection of Sepsis Markers in Whole Blood using Nanocomposite Coated Electrochemical Sensors

2020 ◽  
Author(s):  
Uroš Zupančič ◽  
Pawan Jolly ◽  
Pedro Estrela ◽  
Despina Moschou ◽  
Donald E. Ingber
Keyword(s):  
Electrochemical Detection ◽  
Whole Blood ◽  
Electrochemical Sensors ◽  
Point Of Care ◽  
Sample Volume ◽  
Nanocomposite Coating ◽  
Cross Reactivity ◽  
Detection Methods ◽  
Clinical Samples ◽  
Undiluted Serum

ABSTRACTSepsis is a leading cause of mortality worldwide that is difficult to diagnose and manage because this requires simultaneous analysis of multiple biomarkers. Electrochemical detection methods could potentially provide a way to accurately quantify multiple sepsis biomarkers in a multiplexed manner as they have very low limits of detection and require minimal sensor instrumentation; however, affinity-based electrochemical sensors are usually hampered by biological fouling. Here we describe development of an electrochemical detection platform that enables detection of multiple sepsis biomarkers simultaneously by incorporating a recently developed nanocomposite coating composed of crosslinked bovine serum albumin containing a network of reduced graphene oxide nanoparticles that prevents biofouling. Using nanocomposite coated planar gold electrodes, we constructed a procalcitonin sensor and demonstrated sensitive PCT detection in undiluted serum and clinical samples, as well as excellent correlation with a conventional ELISA (adjusted r2 = 0.95). Sensors for two additional sepsis biomarkers — C-reactive protein and pathogen-associated molecular patterns — were developed on the same multiplexed platform and tested in whole blood. Due to the excellent antifouling properties of the nanocomposite coating, all three sensors exhibited specific responses within the clinically significant range without any cross-reactivity in the same channel with low sample volume. This platform enables sensitive simultaneous electrochemical detection of multiple analytes in human whole blood, which can be expanded further to any target analyte with an appropriate antibody pair or capturing probe, and thus, may offer a potentially valuable tool for development of clinical point-of-care diagnostics.GRAPHICAL ABSTRACT

Molecularly Imprinted Electrochemical Sensors

2012 ◽  
pp. 1-34 ◽  
Author(s):  
Daniel Antuña-Jiménez ◽  
Goretti Díaz-Díaz ◽  
M. Carmen Blanco-López ◽  
M. Jesús Lobo-Castañón ◽  
Arturo J. Miranda-Ordieres ◽  
...  
Keyword(s):  
Electrochemical Sensors ◽  
Molecularly Imprinted
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