A selective and robust UPLC-MS/MS method for the simultaneous quantitative determination of anlotinib, ceritinib and ibrutinib in rat plasma and its application to a pharmacokinetic study

The Analyst ◽  
2019 ◽  
Vol 144 (18) ◽  
pp. 5462-5471 ◽  
Author(s):  
Ping Du ◽  
Yin Guan ◽  
Zhuoling An ◽  
Pengfei Li ◽  
Lihong Liu
Keyword(s):  
Mass Spectrometry ◽  
Kinase Inhibitors ◽  
Rat Plasma ◽  
Tandem Mass ◽  
Spectrometry Method ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Ultrahigh Performance Liquid Chromatography ◽  
First Time

A selective, robust ultrahigh performance liquid chromatography tandem mass spectrometry method was developed for the first time for the simultaneous determination of next-generation antitumor tyrosine kinase inhibitors in rat plasma using protein precipitation extraction.

Sign in / Sign up

Export Citation Format

Share Document