scholarly journals Gold nanoparticle amplification strategies for multiplex SPRi-based immunosensing of human pancreatic islet hormones

The Analyst ◽  
2019 ◽  
Vol 144 (8) ◽  
pp. 2541-2549 ◽  
Author(s):  
F. Rafael Castiello ◽  
Maryam Tabrizian
Keyword(s):  
Pancreatic Islets ◽  
Gold Nanoparticle ◽  
Pancreatic Islet ◽  
Glucose Homeostasis ◽  
The Body ◽  
Human Pancreatic Islet ◽  
Islet Hormones ◽  
Potential Use

In this work, we demonstrate the potential use of SPRi for secretion-monitoring of pancreatic islets, small micro-organs that regulate glucose homeostasis in the body.

scholarly journals Expression profile of mRNAs from human pancreatic islet tumors

2003 ◽  
Vol 31 (3) ◽  
pp. 519-528 ◽  
Author(s):  
L Jin ◽  
H Wang ◽  
T Narita ◽  
R Kikuno ◽  
O Ohara ◽  
...  
Keyword(s):  
Pancreatic Islets ◽  
Pancreatic Islet ◽  
Expression Profile ◽  
Endocrine Pancreas ◽  
New Members ◽  
Human Pancreatic Islets ◽  
Human Pancreatic Islet ◽  
Peptide Database ◽  
Protein Functions ◽  
Complete Set

In order to understand the tIssue specificity of the endocrine pancreas, it is important to clarify the expression profile of mRNAs in various states of the tIssue. A total of approximately 9000 non-redundant expressed genes from human pancreatic islets and insulinoma have so far been determined as expressed sequence tags (ESTs) and deposited in public databases. In the present study towards the identification of a complete set of genes expressed in human pancreatic islets, we have determined 3'-ESTs of 21267 clones randomly selected from a cDNA library of human pancreatic islet tumors. Clustering analysis generated 6157 non-redundant sequences comprising 2323 groups and 3834 singletons. Nucleotide and peptide database searches show that 3103 of them represent known human sequences or homologs of genes identified in other species and 58 are new members of structurally related families. The sequences were classified on the basis of the putative protein functions encoded, and were assigned to the respective chromosome by database analysis. The sequences were also compared with the EST databases (dbEST and EPConDB) including ESTs from normal pancreatic islet, insulinoma, and fetal pancreas. Since 3384 genes were newly found to be expressed in human pancreatic islets and 587 of them were unique to the islets, this study has considerably expanded the catalog of genes expressed in the endocrine pancreas. The larger collection of pancreatic islet-related ESTs should provide a better genome source for molecular studies of differentiation, tIssue-specific functions, and tumorigenesis of the endocrine pancreas as well as for genetic studies of diabetes mellitus.

2080-P: Lipid Profiles from Individual Cells of the Human Pancreatic Islet

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2080-P
Author(s):  
STANISLAV RUBAKHIN ◽  
JONATHAN V. SWEEDLER
Keyword(s):  
Pancreatic Islet ◽  
Lipid Profiles ◽  
Human Pancreatic Islet

Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor

Diabetes ◽  
1995 ◽  
Vol 44 (10) ◽  
pp. 1202-1208 ◽  
Author(s):  
S. Gremlich ◽  
A. Porret ◽  
E. H. Hani ◽  
D. Cherif ◽  
N. Vionnet ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Chromosomal Localization ◽  
Functional Expression ◽  
Human Pancreatic Islet

Efficient gene transfer to dispersed human pancreatic islet cells in vitro using adenovirus-polylysine/DNA complexes or polycationic liposomes

Diabetes ◽  
1996 ◽  
Vol 45 (9) ◽  
pp. 1197-1203 ◽  
Author(s):  
J. Saldeen ◽  
D. T. Curiel ◽  
D. L. Eizirik ◽  
A. Andersson ◽  
E. Strandell ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Pancreatic Islet ◽  
Islet Cells ◽  
Pancreatic Islet Cells ◽  
Dna Complexes ◽  
Human Pancreatic Islet ◽  
Efficient Gene
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