scholarly journals Therapeutic effects of ethanolic extract from the green cocoon shell of silkworm Bombyx mori on type 2 diabetic mice and its hypoglycaemic mechanism

2019 ◽  
Vol 8 (3) ◽  
pp. 407-420 ◽  
Author(s):  
Jin-Ge Zhao ◽  
Hai-Yan Wang ◽  
Zheng-Guo Wei ◽  
Yu-Qing Zhang
Keyword(s):  
Diabetes Mellitus ◽  
Bombyx Mori ◽  
Protein Metabolism ◽  
Complex Disease ◽  
Ethanolic Extract ◽  
Therapeutic Effects ◽  
Diabetic Mice ◽  
Type 2 Diabetic ◽  
Silkworm Bombyx Mori

Diabetes mellitus is a clinically complex disease characterized by hyperglycaemia with disturbances in carbohydrate, fat and protein metabolism.

scholarly journals Serum Levels of Zinc and Magnesium in Newly Diagnosed Type-2 Diabetic Subjects

2013 ◽  
Vol 3 (2) ◽  
pp. 46-49 ◽  
Author(s):  
S Ferdousi ◽  
FH Mollah ◽  
MAR Mia
Keyword(s):  
Diabetes Mellitus ◽  
Protein Metabolism ◽  
Serum Zinc ◽  
Serum Levels ◽  
Newly Diagnosed ◽  
Group I ◽  
Strong Relation ◽  
Type 2 Diabetic ◽  
Group 1

Diabetes mellitus is a chronic metabolic disorder which affects carbohydrate, lipid and protein metabolism. There is a strong relation between some specific oligoelements and diabetes mellitus. The study was undertaken to determine serum levels of zinc and magnesium in 60 newly diagnosed uncomplicated type 2 diabetic (group I) and 60 healthy non-diabetic subjects (group II). Serum zinc and magnesium were estimated by Atomic Absorption Spectrophotometer (AAS). The serum zinc and magnesium levels were (72.70±8.43 ?g/dl) and (1.85±0.17 mg/dl) respectively in group-1 and (75.92±8.20 ?g/dl) and (2.00±0.17 mg/dl) respectively in group-11. The levels were significantly decreased in group-1. Study showed that type 2 diabetes mellitus can result in changes in zinc and magnesium levels and supplementation of both zinc and magnesium may be considered in those cases.DOI: http://dx.doi.org/10.3329/bjmb.v3i2.13811 Bangladesh J Med Biochem 2010; 3(2): 46-49

scholarly journals Amelioration of renal alterations in obese type 2 diabetic mice by vasohibin-1, a negative feedback regulator of angiogenesis

2011 ◽  
Vol 300 (4) ◽  
pp. F873-F886 ◽  
Author(s):  
Daisuke Saito ◽  
Yohei Maeshima ◽  
Tatsuyo Nasu ◽  
Hiroko Yamasaki ◽  
Katsuyuki Tanabe ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Therapeutic Efficacy ◽  
Transforming Growth Factor ◽  
Angiogenesis Inhibitor ◽  
Therapeutic Effects ◽  
Mrna Levels ◽  
Diabetic Mice ◽  
Protein Levels ◽  
Type 2 Diabetic

The involvement of VEGF-A as well as the therapeutic efficacy of angiogenesis inhibitors in diabetic nephropathy have been reported. We recently reported the therapeutic effects of vasohibin-1 (VASH-1), an endogenous angiogenesis inhibitor, in a type 1 diabetic nephropathy model (Nasu T, Maeshima Y, Kinomura M, Hirokoshi-Kawahara K, Tanabe K, Sugiyama H, Sonoda H, Sato Y, Makino H. Diabetes 58: 2365–2375, 2009). In this study, we investigated the therapeutic efficacy of VASH-1 on renal alterations in obese mice with type 2 diabetes. Diabetic db/db mice received intravenous injections of adenoviral vectors encoding human VASH-1 (AdhVASH-1) and were euthanized 8 wk later. AdhVASH-1 treatment resulted in significant suppression of glomerular hypertrophy, glomerular hyperfiltration, albuminuria, increase in the CD31+ glomerular endothelial area, F4/80+ monocyte/macrophage infiltration, the accumulation of type IV collagen, and mesangial matrix. An increase in the renal levels of VEGF-A, VEGFR-2, transforming growth factor (TGF)-β1, and monocyte chemoattractant protein-1 in diabetic animals was significantly suppressed by AdhVASH-1 (immunoblotting). AdhVASH-1 treatment significantly recovered the loss and altered the distribution patterns of nephrin and zonula occludens (ZO)-1 and suppressed the increase in the number of fibroblast-specific protein-1 (FSP-1+) and desmin+ podocytes in diabetic mice. In vitro, recombinant human VASH-1 (rhVASH-1) dose dependently suppressed the upregulation of VEGF induced by high ambient glucose (25 mM) in cultured mouse podocytes. In addition, rhVASH-1 significantly recovered the mRNA levels of nephrin and the protein levels of ZO-1 and P-cadherin and suppressed the increase in protein levels of desmin, FSP-1, Snail, and Slug in podocytes under high-glucose condition. Taken together, these results suggest the potential use of VASH-1 as a novel therapeutic agent in type 2 diabetic nephropathy mediated via antiangiogenic effects and maintenance of podocyte phenotype in association with antiproteinuric effects.

Abstract 129: Brain-Heart Interaction After Stroke: Therapeutic Effects of Exosomes in Type 2 Diabetic Mice Subjected to Stroke

Stroke ◽  
2019 ◽  
Vol 50 (Suppl_1) ◽  
Author(s):  
Poornima Venkat ◽  
Chengcheng Cui ◽  
Jiang Xu ◽  
Alex Zacharek ◽  
Xiao-Ping Yang ◽  
...  
Keyword(s):  
Therapeutic Effects ◽  
Diabetic Mice ◽  
Type 2 Diabetic

scholarly journals Lactobacillus plantarum HAC01 ameliorates type 2 diabetes in high-fat diet and streptozotocin-induced diabetic mice in association with modulating the gut microbiota

2021 ◽  
Author(s):  
Young-Sil Lee ◽  
Daeyoung Lee ◽  
Gun-Seok Park ◽  
Seung-Hyun Ko ◽  
Juyi Park ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
Therapeutic Effects ◽  
Diabetic Mice ◽  
High Fat ◽  
P Type

Type 2 diabetes mellitus (T2DM) is a serious metabolic disorder that occurs worldwide; however, this condition can be managed with probiotics. We assessed the potential therapeutic effects of Lactobacillus plantarum...

scholarly journals In Vivo Antidiabetic Activities of Polyherbal Extracts against Streptozotocin- Nicotinamide Induced Type 2 Diabetic Mice Model

2021 ◽  
Vol 47 (3) ◽  
pp. 877-891
Author(s):  
Pradnya Jagtap ◽  
Yashashri Nimbalkar ◽  
Vidya Patil ◽  
Ravindra Y. Patil
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Density Lipoprotein ◽  
Alternative Therapies ◽  
Tinospora Cordifolia ◽  
Antidiabetic Activity ◽  
Oral Glucose ◽  
Diabetic Mice ◽  
Type 2 Diabetic

Diabetes mellitus is a chronic metabolic disorder and rapidly increasing cases of diabetes throughout the world are major concerns in both developed and developing countries. Currently available oral antidiabetic medicines have limitations in efficacy and safety, which in conjunction with the emergence of diabetes mellitus as a global epidemic have aided the popularity of alternative therapies to manage the disease safely and more efficiently. Herbal medicines are accepted as alternative therapies for blood sugar control. Gymnema sylvestre, Boerhavia diffusa, Tinospora cordifolia, and Argyreia nervosa are some potent herbs used for the management of diabetes. Mixing of these plants in different ratios may produce synergistic antidiabetic actions which may have greater antidiabetic activity. Hence, the present study aimed to determine the anti-diabetic activities of polyherbal extracts in streptozotocin-nicotinamide induced type 2 diabetic mice. The administration of polyherbal extract orally at doses of 100, 200 and 400 mg/kg significantly decreased the blood glucose levels compared to the control diabetic mice. The polyherbal extract significantly lowered the elevated total cholesterol, triglycerides and low-density lipoprotein levels, while increased the high-density lipoprotein indicating antihyperlipidemic activity. The present study reveals that polyherbal extract at a dose of 400 mg/kg body weight resulted in a significant decline (p < 0.001) in blood glucose level. Keywords: Polyherbal extracts; diabetes mellitus; Oral glucose tolerance test; Streptozotocin-Nicotinamide

Therapeutic effects of interleukin-1 receptor-associated kinase 4 inhibitor AS2444697 on diabetic nephropathy in type 2 diabetic mice

2020 ◽  
Vol 393 (7) ◽  
pp. 1197-1209
Author(s):  
Mitsuhiro Kondo ◽  
Atsuo Tahara ◽  
Kazumi Hayashi ◽  
Hiroshi Inami ◽  
Takeshi Ishikawa ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Interleukin 1 ◽  
Therapeutic Effects ◽  
Diabetic Mice ◽  
Type 2 Diabetic

scholarly journals Therapeutic Effects of Canagliflozin and Zinc Sulphate Alone and in Combination on Pancreatic Histology in Type-2 Diabetic Rat Model

2020 ◽  
Vol 34 (3) ◽  
pp. 35-40
Author(s):  
Bushra Suhail
Keyword(s):  
Diabetes Mellitus ◽  
Rat Model ◽  
Zinc Sulphate ◽  
Combined Treatment ◽  
Pancreatic Tissue ◽  
Diabetic Rat ◽  
Therapeutic Effects ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic

Introduction: Diabetes Mellitus is a common metabolic syndrome characterized by persistently elevated blood glucose levels. Canagliflozin is an SGLT-2 inhibitor that controls hyperglycemia by reducing the reabsorption of filtered glucose and excreting it in the urine. Zinc sulphate exhibits some beneficial role in diabetes mellitus but has not been compared to canagliflozin individually and in combination. Aims & Objectives: To observe the effects of treatment with canagliflozin and zinc sulphate on pancreatic histology in streptozotocin induced type-2 diabetic rat model. Place and duration of study: The study was conducted in the Department of Pharmacology, KEMU and PGMI, Lahore for the period of two months. Material & Methods: It was an animal experimental study of eight weeks duration in which 48 adult healthy albino rats of male gender were divided into six groups and were provided the high fat diet throughout the study period. Groups A and B were maintained as healthy and diseased controls respectively. Groups B, C, D, E and F were administered single I/P dose streptozotocin (35mg/kg) at day 22 for inducing diabetes. Upon confirmation of diabetes after a week the rats were further treated as per group designation orally for 4 weeks , individually or in combination with full or half doses of canagliflozin (10 mg /kg/day, 5mg/kg/day ) and zinc sulphate (30mg/kg/day, 15mg/kg/day) . All animals were euthanized at the completion of study duration. The pancreatic tissue was taken out and examined for the histopathological changes (size and number of pancreatic islets, karyolysis and ballooning degeneration). Results: There was a marked improvement in the size and number of islets as well as the inflammatory changes in the combined treatment group (with canagliflozin in full as well as half dose of zinc sulphate) as compared to the groups given zinc sulphate and canagliflozin separately. Conclusion: Combined treatment with canagliflozin and zinc sulphate has a better protective effect on the pancreatic tissue in diabetes than either of them used alone.

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