scholarly journals Effects of paternal electromagnetic pulse exposure on the reproductive endocrine function of male offspring: a pilot study

2018 ◽  
Vol 7 (6) ◽  
pp. 1120-1127 ◽  
Author(s):  
Ming-juan Yang ◽  
Hai-yang Lang ◽  
Xia Miao ◽  
Hai-qiang Liu ◽  
Yan-jun Zhang ◽  
...  
Keyword(s):  
Pilot Study ◽  
Electromagnetic Pulse ◽  
Reproductive Toxicity ◽  
Male Offspring ◽  
Endocrine Function ◽  
Pulse Exposure ◽  
Reproductive Endocrine

The hypothalamic GABAA receptor may be involved in the reproductive toxicity in male offspring due to paternal electromagnetic pulse exposure.

Differential effects of levetiracetam, carbamazepine, and lamotrigine on reproductive endocrine function in adults

2009 ◽  
Vol 16 (2) ◽  
pp. 281-287 ◽  
Author(s):  
Sigrid Svalheim ◽  
Erik Taubøll ◽  
Gerhard Luef ◽  
Andreas Lossius ◽  
Markus Rauchenzauner ◽  
...  
Keyword(s):  
Endocrine Function ◽  
Differential Effects ◽  
Reproductive Endocrine

Reproductive hormone secretion and spermatogenic function in thyroidectomized rams receiving graded doses of exogenous thyroxine

1986 ◽  
Vol 111 (2) ◽  
pp. 245-253 ◽  
Author(s):  
Y. Chandrasekhar ◽  
M. J. D'Occhio ◽  
B. P. Setchell
Keyword(s):  
Hormone Secretion ◽  
Reproductive Function ◽  
Pulse Frequency ◽  
Endocrine Function ◽  
Sex Hormone Binding Globulin ◽  
Testosterone Levels ◽  
Reproductive Endocrine ◽  
Lh Release ◽  
Lh Releasing Hormone ◽  
The Relationship

ABSTRACT This study aimed to obtain a better understanding of the relationship between circulating thyroxine (T4) concentrations and reproductive endocrine function in the ram. Mature Merino rams were thyroidectomized and supplemented with 0, 30, 100 and 300% of normal T4 for 10 weeks. Thyroidectomy had no apparent effect on spermatogenic function but interfered with sperm maturation, the latter being returned to normal by 30% T4 replacement. Circulating testosterone levels were reduced by thyroidectomy and restored to control levels by 30% T4; when T4 levels were supranormal (300%), circulating testosterone levels were again reduced. The lowered circulating testosterone levels in thyroidectomized rams occurred as a result of suppressed testosterone secretion from the testis, observed under basal conditions and also following LH-releasing hormone (LHRH) and human chorionic gonadotrophin injection. In thyroidectomized rams, sex hormone binding globulin (SHBG) levels were depressed without changes in testosterone clearance rate (TCR), while in rams with supranormal T4 levels, TCR was increased without changes in SHBG levels. Subnormal levels of T4 also restored to normal the reduced LH pulse frequency in thyroidectomized rams. Reduced LH pulse frequency, together with diminished LH release following LHRH injection in thyroidectomized rams, suggested effects of T4 at the hypothalamo-pituitary axis. The present study demonstrates that complete lack of thyroid hormones suppresses normal reproductive endocrine function in the ram, but that this can be restored to normal by 30% T4 replacement. The results support the theory that T4 plays a permissive rather than a regulatory role in reproductive function in males. J. Endocr. (1986) 111, 245–253

Electromagnetic Pulse Exposure Induces Overexpression of Beta Amyloid Protein in Rats

2013 ◽  
Vol 44 (3) ◽  
pp. 178-184 ◽  
Author(s):  
Da-peng Jiang ◽  
Jing Li ◽  
Jie Zhang ◽  
Sheng-long Xu ◽  
Fang Kuang ◽  
...  
Keyword(s):  
Electromagnetic Pulse ◽  
Beta Amyloid ◽  
Amyloid Protein ◽  
Pulse Exposure ◽  
Beta Amyloid Protein

Reproductive toxicity and toxicokinetics of lindane in the male offspring of rats exposed during lactation

1997 ◽  
Vol 16 (3) ◽  
pp. 146-153 ◽  
Author(s):  
PR Dalsenter ◽  
AS Faqi ◽  
J. Webb ◽  
H-J. Merker ◽  
I. Chahoud
Keyword(s):  
Single Dose ◽  
Testosterone Level ◽  
Reproductive Toxicity ◽  
Maternal Plasma ◽  
Male Offspring ◽  
Pronounced Effect ◽  
Toxicity Study ◽  
Testicular Weight

1 Reproductive toxicity and toxicokinetics of lindane during lactation were studied. For the reproductive toxicity study the dams were treated with a single dose of 6 mg/kg on day 9 or 14 of lactation, or with 1 mg/kg on days 9 to 14 of lactation. The male offspring were investigated at puberty and adulthood. For the toxicokinetic study, two groups of dams were treated with 6 mg/kg on day 9 or 14 of lactation. The concentration of lindane was measured in maternal plasma and milk, as well as in male offspring organs. 2 At adulthood, testicular weight and the number of sperm and spermatids were significantly reduced in all treated groups. 3 The testosterone level of the groups treated with 6 mg/ kg was significantly reduced to approximately 50% at puberty as well as in adulthood. In the group treated with 1 mg/kg, the testosterone level was in both age periods reduced, however, only at puberty was the reduction statistically significant. 4 The concentration oflindane in the testis was similar to that found in brain and was half the concentration found in the liver. 5 Histologically some areas of the testis exhibited distinct alterations ranging from small changes to a pronounced effect. 6 Exposure to lindane during lactation induces repro ductive hazards to male offspring rats which are detectable at adulthood.

Effects of electromagnetic pulse exposure on gelatinase of blood–brain barrierin vitro

2016 ◽  
pp. 1-7
Author(s):  
Yan Zhou ◽  
Lian-Bo Qiu ◽  
Guang-Zhou An ◽  
Jia-Xing Zhou ◽  
Le Du ◽  
...  
Keyword(s):  
Electromagnetic Pulse ◽  
Pulse Exposure ◽  
Blood Brain

Sexual maturation and fertility of male and female mice exposed prenatally and postnatally to trivalent and hexavalent chromium compounds

1998 ◽  
Vol 10 (2) ◽  
pp. 179 ◽  
Author(s):  
M. H. Al-Hamood ◽  
A. Elbetieha ◽  
H. Bataineh
Keyword(s):  
Hexavalent Chromium ◽  
Sexual Maturation ◽  
Potassium Dichromate ◽  
Reproductive Toxicity ◽  
Female Offspring ◽  
Male Offspring ◽  
Experimental Conditions ◽  
Male And Female ◽  
Female Mice ◽  
Chromium Compounds

The reproductive toxicity of trivalent and hexavalent chromium compounds was investigated in male and female mice exposed to 1000 ppm chromium chloride and potassium dichromate via their mother during gestational and lactational periods. Fertility was reduced in male offspring exposed to either trivalent or hexavalent chromium compounds. Body weights and weights of testes, seminal vesicles and preputial glands were reduced in trivalent-exposed male offspring. The exposure of female mice offspring to trivalent and hexavalent chromium compounds delayed sexual maturation. Fertility was reduced in female offspring exposed to either trivalent or hexavalent chromium compounds. The exposure of female mice to hexavalent chromium compound reduced the number of implantations and viable fetuses respectively. Body weight and weights of ovaries and uteri were reduced in trivalent-exposed female offspring. The results indicate that under our experimental conditions, the exposure of male and female mice offspring to either trivalent or hexavalent chromium compounds during gestational and lactational periods impair reproductive functions and fertility in adulthood.

scholarly journals Is maternal obesity related to semen quality in the male offspring? A pilot study

2007 ◽  
Vol 22 (10) ◽  
pp. 2758-2762 ◽  
Author(s):  
C.H. Ramlau-Hansen ◽  
E.A. Nohr ◽  
A.M. Thulstrup ◽  
J.P. Bonde ◽  
L. Storgaard ◽  
...  
Keyword(s):  
Pilot Study ◽  
Maternal Obesity ◽  
Semen Quality ◽  
Male Offspring

Studies on reproductive endocrine function in rats treated with monosodium l-glutamate early in life

1979 ◽  
Vol 4 (5) ◽  
pp. 359-371 ◽  
Author(s):  
Yoshimasa Matsuzawa ◽  
Shinobu Yonetani ◽  
Yutaka Takasaki ◽  
seinosuke Iwata ◽  
Seikichi Sekine
Keyword(s):  
Endocrine Function ◽  
Reproductive Endocrine

scholarly journals Using Kisspeptin to Predict Pubertal Outcomes for Youth With Pubertal Delay

2020 ◽  
Vol 105 (8) ◽  
pp. e2717-e2725 ◽  
Author(s):  
Yee-Ming Chan ◽  
Margaret F Lippincott ◽  
Priscila Sales Barroso ◽  
Cielo Alleyn ◽  
Jill Brodsky ◽  
...  
Keyword(s):  
Medical Center ◽  
Academic Medical Center ◽  
Inhibin B ◽  
Endocrine Function ◽  
Delayed Puberty ◽  
Pubertal Delay ◽  
Gnrh Release ◽  
Stimulation Tests ◽  
Reproductive Endocrine ◽  
Outcomes For Children

Abstract Context The management of youth with delayed puberty is hampered by difficulty in predicting who will eventually progress through puberty and who will fail to attain adult reproductive endocrine function. The neuropeptide kisspeptin, which stimulates gonadotropin-releasing hormone (GnRH) release, can be used to probe the integrity of the reproductive endocrine axis. Objective We sought to determine whether responses to kisspeptin can predict outcomes for individuals with pubertal delay. Design, Setting, and Participants We conducted a longitudinal cohort study in an academic medical center of 16 children (3 girls and 13 boys) with delayed or stalled puberty. Intervention and Outcome Measures Children who had undergone kisspeptin- and GnRH-stimulation tests were followed every 6 months for clinical evidence of progression through puberty. Inhibin B was measured in boys. A subset of participants underwent exome sequencing. Results All participants who had responded to kisspeptin with a rise in luteinizing hormone (LH) of 0.8 mIU/mL or greater subsequently progressed through puberty (n = 8). In contrast, all participants who had exhibited LH responses to kisspeptin ≤ 0.4 mIU/mL reached age 18 years without developing physical signs of puberty (n = 8). Thus, responses to kisspeptin accurately predicted later pubertal outcomes (P = .0002). Moreover, the kisspeptin-stimulation test outperformed GnRH-stimulated LH, inhibin B, and genetic testing in predicting pubertal outcomes. Conclusion The kisspeptin-stimulation can assess future reproductive endocrine potential in prepubertal children and is a promising novel tool for predicting pubertal outcomes for children with delayed puberty.

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