pH-sensitive polymeric micelles assembled by stereocomplexation between PLLA-b-PLys and PDLA-b-mPEG for drug delivery

2019 ◽  
Vol 7 (2) ◽  
pp. 334-345 ◽  
Author(s):  
Zhaoyuan Guo ◽  
Ke Zhao ◽  
Rong Liu ◽  
Xiaolan Guo ◽  
Bin He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Ethylene Glycol ◽  
Polymeric Micelles ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

pH-responsive stereocomplexed micelles based on poly(l-lactic acid)-b-polylysine/poly(d-lactic acid)-b-methoxy poly(ethylene glycol) (PLLA-b-PLys/PDLA-b-mPEG) were fabricated by stereocomplexation between enantiomeric PLA segments.

A Tunable pH-Responsive Nanomaterials for Cancer Delivery

2013 ◽  
Vol 750-752 ◽  
pp. 1476-1479 ◽  
Author(s):  
Bin Liu ◽  
Guan Hui Gao ◽  
Peng Liu ◽  
Hu Qiang Yi ◽  
Wei Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Potential Application ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Positive Potential ◽  
Ph Values ◽  
Drugs In Blood ◽  
Poly Ethylene

In this paper, we successfully designed a pH-responsive micelles based on hybrid polypeptide copolymers of poly (L-lysine-4-Azepan-1-yl-butyric)-b-poly (ethylene glycol)-b-poly (L-lysine-Diisopropylamide)-b-poly (L-leucine) (PLL(A)-PEG-PLL(B)-PLLeu) for efficient drug delivery. This pH-responsive nanoparticles were able to response to different pH values (pH=6.8 and 5.5). In vitro, these nanoparticles exhibited a stable and evenly distributed approximately 51 nm, a slightly positive potential about 10.3 mv at pH 7.4, which were crucial for the circulation of drugs in blood. While size and potential were about 130 nm and 34.7 mv at pH 6.8, which were good for drugs in membrane. Furthermore, the loading capability of DOX was up to 11.3%, and the pH-responsive release efficiency reached to 68.3% at pH 5.5. The results indicated that these micelles had huge potential application in cancer delivery.

Methoxy poly(ethylene glycol)-block-poly(D,L-lactic acid) copolymer nanoparticles as carriers for transdermal drug delivery

2007 ◽  
Vol 57 (2) ◽  
pp. 268-274 ◽  
Author(s):  
Jun Li ◽  
Yinglei Zhai ◽  
Bin Zhang ◽  
Liandong Deng ◽  
Yongshen Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Ethylene Glycol ◽  
Transdermal Drug Delivery ◽  
Poly Ethylene Glycol ◽  
Acid Copolymer ◽  
Poly Ethylene

scholarly journals pH-Responsive Poly(Ethylene Glycol)-block-Polylactide Micelles for Tumor-Targeted Drug Delivery

2017 ◽  
Vol 18 (9) ◽  
pp. 2711-2722 ◽  
Author(s):  
Lin Xiao ◽  
Lixia Huang ◽  
Firmin Moingeon ◽  
Mario Gauthier ◽  
Guang Yang
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Targeted Drug ◽  
Poly Ethylene

scholarly journals Tumor pH-responsive flower-like micelles of poly(l-lactic acid)-b-poly(ethylene glycol)-b-poly(l-histidine)

2007 ◽  
Vol 123 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Eun Seong Lee ◽  
Kyung Taek Oh ◽  
Dongin Kim ◽  
Yu Seok Youn ◽  
You Han Bae
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Tumor Ph ◽  
Poly Ethylene
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