A single fluorescent probe for imaging ribonucleic acid and sulfur dioxide in living systems and its unique application in tumor and normal cells

2018 ◽  
Vol 6 (41) ◽  
pp. 6607-6614 ◽  
Author(s):  
Weishan Wang ◽  
Yong Liu ◽  
Jie Niu ◽  
Weiying Lin
Keyword(s):  
Sulfur Dioxide ◽  
Fluorescent Probe ◽  
Ribonucleic Acid ◽  
Living Systems ◽  
Normal Cells ◽  
Unique Application

Herein, the development of EPI-RS is described as the first paradigm of a probe that could image RNA and SO2 with distinct fluorescence signals in living systems.

A near-infrared fluorescent probe targeting mitochondria for sulfite detection and its application in food and biology

2021 ◽  
Author(s):  
Jianbin Chao ◽  
Zhuo Wang ◽  
Yongbin Zhang ◽  
Fangjun Huo ◽  
Caixia Yin
Keyword(s):  
Cardiovascular Diseases ◽  
Sulfur Dioxide ◽  
Human Health ◽  
Fluorescent Probe ◽  
Respiratory Diseases ◽  
Near Infrared ◽  
Air Pollutant ◽  
Great Harm

Abstract: Sulfur dioxide (SO2) is the main air pollutant in the environment, causing great harm to human health. Abnormal SO2 levels are usually associated with some respiratory diseases, cardiovascular diseases,...

Insight into sulfur dioxide and its derivatives metabolism in living system with visualized evidences via ultra-sensitive fluorescent probe

2022 ◽  
Vol 423 ◽  
pp. 127179
Author(s):  
Xia Zhang ◽  
Li Zhang ◽  
Shudi Liu ◽  
Xiaozhen Zhu ◽  
Panpan Zhou ◽  
...  
Keyword(s):  
Sulfur Dioxide ◽  
Fluorescent Probe ◽  
Living System ◽  
Insight Into

scholarly journals Preferential expression of double-stranded ribonucleic acid in tumor versus normal cells: biological and clinical implications

Blood ◽  
1985 ◽  
Vol 66 (1) ◽  
pp. 39-46
Author(s):  
HM Kantarjian ◽  
B Barlogie ◽  
M Pershouse ◽  
D Swartzendruber ◽  
MJ Keating ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Cell Lines ◽  
Ribonucleic Acid ◽  
Flow Cytometric Analysis ◽  
Myelogenous Leukemia ◽  
Cycle Phase ◽  
Low Grade ◽  
Normal Cells ◽  
Normal Peripheral Blood ◽  
Rna Content

In an effort to develop a new tumor marker suitable for flow cytometric analysis, we examined the value of double-stranded ribonucleic acid (ds- RNA) measurements using propidium iodide after DN'ase treatment. Cellular ds-RNA content was evaluated both in experimental cell lines and in clinical specimens. Higher levels of ds-RNA were present in tumor cells as compared with normal cells. In tumor cells, fluorescence was intensely localized in the nucleolus and was more diffuse in the cytoplasm. Change of less than 10% in the ds-RNA levels was observed in cell lines as a function of cytokinetic determinants such as cycle phase, culture age, and cycle traverse rate. Tumor differentiation by dimethylsulfoxide resulted in a significant decrease in cellular ds-RNA content. For quantitative comparison of clinical material, a ds-RNA excess was defined in relationship to normal peripheral blood lymphocytes. ds-RNA excess greater than 30% was observed in only one of 34 normal tissues (3%) as compared with 124 of 201 neoplastic tissue samples (62%). This incidence was higher in patients with acute leukemia (76%), high-grade and intermediate-grade lymphoma (75%), and high tumor stage myeloma (83%), as compared with chronic leukemia (20%), low-grade lymphoma (25%), and intermediate or low tumor mass myeloma (43%). Prognostically, a high pretreatment ds-RNA excess in myeloma was associated with a lower remission rate. The persistence of ds-RNA excess in the bone marrow of patients with acute myelogenous leukemia in remission predicted for a shorter remission duration (seven v 22 months; P = .05). We conclude that ds-RNA excess, as readily measured objectively and quantitatively by flow cytometry, may have important diagnostic and prognostic implications for the management of patients with malignant disease.

scholarly journals An effective biocompatible fluorescent probe for bisulfite detection in aqueous solution, living cells, and mice

RSC Advances ◽  
2020 ◽  
Vol 10 (42) ◽  
pp. 25352-25357 ◽  
Author(s):  
Ruqiao Zhou ◽  
Guiling Cui ◽  
Yuefu Hu ◽  
Qingrong Qi ◽  
Wencai Huang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Sulfur Dioxide ◽  
Human Health ◽  
Fluorescent Probe ◽  
Living Cells ◽  
Air Pollutant

Sulfur dioxide, an air pollutant, is easily hydrated to sulfites and bisulfites and extremely harmful to human health.

A carbonothioate-based far-red fluorescent probe for the specific detection of mercury ions in living cells and zebrafish

The Analyst ◽  
2019 ◽  
Vol 144 (4) ◽  
pp. 1426-1432 ◽  
Author(s):  
Qingxia Duan ◽  
Hanchuang Zhu ◽  
Caiyun Liu ◽  
Ruifang Yuan ◽  
Zhaotong Fang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Water Samples ◽  
Environmental Water ◽  
Living Cells ◽  
Living Systems ◽  
Environmental Water Samples ◽  
Mercury Ions ◽  
Specific Detection

A simple far-red fluorescent probe was developed to monitor mercury ions in environmental water samples and in living systems.

A ratiometric fluorescent probe for reversible monitoring of endogenous SO2/formaldehyde in cytoplasm and nucleoli regions and its applications in living mice

The Analyst ◽  
2020 ◽  
Vol 145 (5) ◽  
pp. 1865-1870 ◽  
Author(s):  
Yanyan Ma ◽  
Wenjie Gao ◽  
Linlin Zhu ◽  
Yuping Zhao ◽  
Weiying Lin
Keyword(s):  
Sulfur Dioxide ◽  
Fluorescent Probe ◽  
Living Cells ◽  
Ratiometric Fluorescent Probe

A ratiometric fluorescent probe was engineered for the reversible imaging of endogenous sulfur dioxide in the cytoplasm and nucleoli regions of living cells and in living mice.

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