Chemoenzymatic synthesis of dual-responsive graft copolymers for drug delivery: long-term stability, high loading and cell selectivity

2018 ◽  
Vol 6 (43) ◽  
pp. 6993-7003 ◽  
Author(s):  
Jun Li ◽  
Xian-Ling Yang ◽  
Yan-Hong Liu ◽  
Wan-Xia Wu ◽  
Bei-Yu Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graft Copolymers ◽  
Chemoenzymatic Synthesis ◽  
High Loading ◽  
Term Stability ◽  
Long Term Stability ◽  
Dual Responsive ◽  
Cell Selectivity

Dual-responsive graft copolymers with long-term stability and high loading were synthesized through a chemoenzymatic method and successfully utilized in drug delivery.

GSH/pH dual-responsive biodegradable camptothecin polymeric prodrugs combined with doxorubicin for synergistic anticancer efficiency

2019 ◽  
Vol 7 (8) ◽  
pp. 3277-3286 ◽  
Author(s):  
Jun Li ◽  
Zu-E. Hu ◽  
Xian-Ling Yang ◽  
Wan-Xia Wu ◽  
Xiu Xing ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Term Stability ◽  
Long Term Stability ◽  
Dual Responsive

GSH and pH dual-responsive camptothecin polymeric prodrugs combined doxorubicin for synergistic drug delivery to highly improved selectivity and synergy benefiting from good long-term stability, better internalization and sensitive dual-responsibility.

Physical Characterisation and Long-Term Stability Studies on Quaternary Ammonium Palmitoyl Glycol Chitosan (GCPQ)—A New Drug Delivery Polymer

2014 ◽  
Vol 103 (8) ◽  
pp. 2296-2306 ◽  
Author(s):  
Kar Wai Chooi ◽  
Margarida Isabel Simão Carlos ◽  
Ramesh Soundararajan ◽  
Simon Gaisford ◽  
Natrah Arifin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quaternary Ammonium ◽  
Stability Studies ◽  
Glycol Chitosan ◽  
Term Stability ◽  
Long Term Stability ◽  
New Drug

scholarly journals Combination of Roll Grinding and High-Pressure Homogenization Can Prepare Stable Bicelles for Drug Delivery

Nanomaterials ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. 998 ◽  
Author(s):  
Seira Matsuo ◽  
Kenjirou Higashi ◽  
Kunikazu Moribe ◽  
Shin-ichiro Kimura ◽  
Shigeru Itai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
High Pressure ◽  
Entrapment Efficiency ◽  
Molar Ratio ◽  
High Pressure Homogenization ◽  
Term Stability ◽  
Long Term Stability ◽  
Long Term Storage ◽  
High Entrapment Efficiency

To improve the solubility of the drug nifedipine (NI), NI-encapsulated lipid-based nanoparticles (NI-LNs) have been prepared from neutral hydrogenated soybean phosphatidylcholine and negatively charged dipalmitoylphosphatidylglycerol at a molar ratio of 5/1 using by roll grinding and high-pressure homogenization. The NI-LNs exhibited high entrapment efficiency, long-term stability, and enhanced NI bioavailability. To better understand their structures, cryo transmission electron microscopy and atomic force microscopy were performed in the present study. Imaging from both instruments revealed that the NI-LNs were bicelles. Structures prepared with a different drug (phenytoin) or with phospholipids (dimyristoylphosphatidylcholine, dipalmitoylphosphatidylcholine, and distearoylphosphatidylcholine) were also bicelles. Long-term storage, freeze-drying, and high-pressure homogenization did not affect the structures; however, different lipid ratios, or the presence of cholesterol, did result in liposomes (5/0) or micelles (0/5) with different physicochemical properties and stabilities. Considering the result of long-term stability, standard NI-LN bicelles (5/1) showed the most long-term stabilities, providing a useful preparation method for stable bicelles for drug delivery.

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