Facile synthesis of near-infrared emitting dBSA-templated Cu nanoclusters for sensitive detection of heparin

2018 ◽  
Vol 6 (34) ◽  
pp. 5466-5475 ◽  
Author(s):  
Xiao-Man Wu ◽  
Fei Zhang ◽  
Yan Li

The near-infrared emitting dBSA-Cu NCs were synthesized through a facile synthesis route and were applied for ultra-sensitive detection of heparin in human plasma.

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2679 ◽  
Author(s):  
Yibin Zhang ◽  
Jianheng Bi ◽  
Shuai Xia ◽  
Wafa Mazi ◽  
Shulin Wan ◽  
...  

A fluorescence resonance energy transfer (FRET)-based near-infrared fluorescent probe (B+) for double-checked sensitive detection of intracellular pH changes has been synthesized by binding a near-infrared rhodamine donor to a near-infrared cyanine acceptor through robust C-N bonds via a nucleophilic substitution reaction. To demonstrate the double-checked advantages of probe B+, a near-infrared probe (A) was also prepared by modification of a near-infrared rhodamine dye with ethylenediamine to produce a closed spirolactam residue. Under basic conditions, probe B+ shows only weak fluorescence from the cyanine acceptor while probe A displays nonfluorescence due to retention of the closed spirolactam form of the rhodamine moiety. Upon decrease in solution pH level, probe B+ exhibits a gradual fluorescence increase from rhodamine and cyanine constituents at 623 nm and 743 nm respectively, whereas probe A displays fluorescence increase at 623 nm on the rhodamine moiety as acidic conditions leads to the rupture of the probe spirolactam rings. Probes A and B+ have successfully been used to monitor intracellular pH alternations and possess pKa values of 5.15 and 7.80, respectively.


2017 ◽  
Vol 468 ◽  
pp. 140-145 ◽  
Author(s):  
Jianheng Bi ◽  
Mingxi Fang ◽  
Jianbo Wang ◽  
Shuai Xia ◽  
Yibin Zhang ◽  
...  

2007 ◽  
Vol 19 (19) ◽  
pp. 2856-2862 ◽  
Author(s):  
E. A. Abou Neel ◽  
A. M. Young ◽  
S. N. Nazhat ◽  
J. C. Knowles

2018 ◽  
Vol 54 (55) ◽  
pp. 7625-7628 ◽  
Author(s):  
Yibin Zhang ◽  
Shuai Xia ◽  
Mingxi Fang ◽  
Wafa Mazi ◽  
Yanbo Zeng ◽  
...  

New near-infrared rhodamine dyes with large Stokes shifts were developed and applied for sensitive detection of cellular pH changes and fluctuations by incorporating an additional amine group with fused rings.


Sign in / Sign up

Export Citation Format

Share Document