Enhanced osteoinductivity of porous biphasic calcium phosphate ceramic beads with high content of strontium-incorporated calcium-deficient hydroxyapatite

2018 ◽  
Vol 6 (41) ◽  
pp. 6572-6584 ◽  
Author(s):  
Yanglong Deng ◽  
Minjun Liu ◽  
Xuening Chen ◽  
Menglu Wang ◽  
Xiangfeng Li ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Regenerative Medicine ◽  
Biphasic Calcium Phosphate ◽  
Calcium Phosphate Ceramic ◽  
Natural Bone ◽  
Development Direction ◽  
Porous Biphasic Calcium Phosphate

Further biomimicking natural bone and enhancing osteoinductivity to meet the requirements of regenerative medicine is the key development direction of biphasic calcium phosphate (BCP) ceramics.

Fully Interconnected Globular Porous Biphasic Calcium Phosphate Ceramic Scaffold Facilitates Osteogenic Repair

2007 ◽  
Vol 361-363 ◽  
pp. 119-122 ◽  
Author(s):  
J.H. Lim ◽  
J.H. Park ◽  
Eui Kyun Park ◽  
Hae Jung Kim ◽  
Il Kyu Park ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate ◽  
Bone Defects ◽  
Calcium Phosphate Ceramic ◽  
Ceramic Scaffold ◽  
Porous Biphasic Calcium Phosphate

An appropriate scaffold, which provides structural support for transplanted cells and acts as a vehicle for the delivery of biologically active molecules, is critical for tissue engineering. We developed a fully interconnected globular porous biphasic calcium phosphate ceramic scaffold by adopting a foaming method, and evaluated its efficiency as a bone substitute and a scaffold for bone tissue engineering by in vitro and in vivo biocompatible analysis and its osteogenic healing capacity in rat tibial bone defects. They have spherical pores averaging 400um in diameter and interconnecting interpores averaging 70um in diameter with average 85% porosity. They elicited no cytotoxicity and noxious effect on cellular proliferation and osteoblastic differentiation during the cell-scaffold construct formation. Also the bone defects grafted with fully interconnected globular porous biphasic calcium phosphate ceramic blocks revealed excellent bone healing within 3 weeks. These findings suggest that the fully interconnected porous biphasic calcium phosphate scaffold formed by the foaming method can be a promising bone substitute and a scaffold for bone tissue engineering.

Performance for Bone Ingrowth of Biphasic Calcium Phosphate Ceramic Versus Bovine Bone Substitute

2006 ◽  
Vol 309-311 ◽  
pp. 1379-1382 ◽  
Author(s):  
G. Daculsi ◽  
P. Corre ◽  
Oliver Malard ◽  
Racquel Z. LeGeros ◽  
Eric Goyenvalle
Keyword(s):  
Calcium Phosphate ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate ◽  
Bone Ingrowth ◽  
Maxillofacial Surgery ◽  
Bovine Bone ◽  
Calcium Phosphate Ceramic ◽  
Porous Biphasic Calcium Phosphate

Calcium phosphate bioceramics and bovine bone xenograft with or without sintering are more or less used in orthopaedics or in maxillofacial surgery. In this study we compare in a rat femoral epiphysis model after 3 weeks of implantation the bone in growth at the expense of granules of same size of micro macro porous biphasic calcium phosphate MBCP, sintered bovine bone and unsintered BioOss.

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