scholarly journals A polymer-free, biomimicry drug self-delivery system fabricatedviaa synergistic combination of bottom-up and top-down approaches

2018 ◽  
Vol 6 (47) ◽  
pp. 7842-7853 ◽  
Author(s):  
Xiaobao Xu ◽  
Gaomai Yang ◽  
Xiangdong Xue ◽  
Hongwei Lu ◽  
Hao Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Membrane ◽  
Delivery System ◽  
Top Down ◽  
Bottom Up ◽  
A Cell ◽  
Pure Drug ◽  
Synergistic Combination

A pure drug self-delivery system with a cell membrane modified to create a unique class of ideal drug delivery platforms.

scholarly journals KARAKTERISASI XRD DAN SEM PADA MATERIAL NANOPARTIKEL SERTA PERAN MATERIAL NANOPARTIKEL DALAM DRUG DELIVERY SYSTEM

2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Iin Lidia Putama Mursal
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Crystallographic Structure ◽  
X Ray Diffraction ◽  
Top Down ◽  
Bottom Up ◽  
X Ray ◽  
Pharmaceutical Application ◽  
Material Grain Size

Abstrak Material nanopartikel merupakan merupakan material dengan ukuran partikel berukuran 10-100 nm. Nanopartikel dapat dibuat dengan beberapa metode yang diklasifikasikan menjadi dua jenis pendekatan yaitu dengan cara top down dan bottom up. Karakterisasi nanopartikel dapat dilakukan dengan menggunakan teknik X-Ray diffraction (XRD) dan Scanning Elekctron Microscopy (SEM). XRD sangat berguna untuk mempelajari struktur kristal, komposisi kimia, dan sifat sifat fisika dari nanomaterial. SEM merupakan teknik karakterisasi material yang banyak digunakan untuk melihat morgfologi permukaan dan ukuran butir nanomaterial. Beberapa waktu belakangan perhatian mengenai naopartikel ini telah diarahkan juga pada aplikasi di bidang farmasi khususnya dalam dalam bidang Drug Delivery System Kata kunci: Nanopartikel, X-Ray diffraction, Scanning Elekctron Microscopy Abstract Nanoparticles are defined as material with a particle size in the range of 10-100 nm. Nanomaterial fabrication methods can be classified according to whether their assembly followed either the so called top down and bottom up approach. Characterization of nanoparticles can use X-Ray diffraction (XRD) and Scanning Electron Microscopy (SEM) techniques. XRD are a very useful characterization tool to study the crystallographic structure, chemical composition and physical properties of nanomaterials. SEM is a popular technique for imaging the surfaces of almost any material grain size of nanomaterial. Recently, attention of nanomaterial has been geared towards its pharmaceutical application, especially in the area of drug delivery. Keywords: Nanoparticles, X-Ray diffraction, Scanning Elekctron Microscopy

Distinct photophysical behaviour and transport of cell-impermeable [Ru(bpy)2dppz]2+ in live cells using cucurbit[7]uril as a delivery system

2018 ◽  
Vol 47 (11) ◽  
pp. 3857-3863 ◽  
Author(s):  
Meenakshi N. Shinde ◽  
Soniya S. Rao ◽  
Shridhar P. Gejji ◽  
Anupa A. Kumbhar
Keyword(s):  
Cell Membrane ◽  
Delivery System ◽  
Live Cells ◽  
System P ◽  
Molecular Container ◽  
A Cell

We have successfully demonstrated the delivery of a cell-impermeable [Ru(bpy)2dppz]2+ complex across the cell membrane in live cells using a cucurbit[7]uril molecular container.

scholarly journals Quartz Crystal Microbalance as a Sensor to Characterize Macromolecular Assembly Dynamics

2009 ◽  
Vol 2009 ◽  
pp. 1-17 ◽  
Author(s):  
K. Kanazawa ◽  
Nam-Joon Cho
Keyword(s):  
Cell Membrane ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
Analytical Techniques ◽  
Top Down ◽  
Macromolecular Assembly ◽  
Basic Measurement ◽  
Quartz Crystal Microbalance Sensor ◽  
A Cell ◽  
Peptide Interaction

The quartz crystal microbalance sensor has a resonant frequency and a quality factor which can be used to probe the properties of nanometer thick film loads. A recent review by Arnau (2008) has discussed many of the considerations necessary to accurately probe for these properties. To avoid needless duplication but to still provide an adequate background for the new user, we briefly outline the basic measurement methodologies and analytical techniques that were covered in the review. Details will be provided on some specific perspectives of the authors. For example, the special precautions necessary when dealing with soft films (polymeric and biological) under liquid are overviewed. To illustrate applications of the QCM technique, simple bilayer and vesicle behaviors are discussed, along with the structural transformation resulting from protein adsorption onto an intact vesicle adlayer. The amphipathic -helical (AH) peptide interaction is given as a particular example. Lastly, we summarize a top-down approach to functionalize a surface with a cell membrane and to study its interaction with proteins.

LIPOSOMES: TYPE, PREAPRATION AND EVALUATION

2021 ◽  
pp. 17-22
Author(s):  
Manish Kumar ◽  
Arpita Singh ◽  
Swarnima Pandey ◽  
Mohd. Aqil Siddiqui ◽  
Nitish Kumar
Keyword(s):  
Drug Delivery ◽  
Cell Membrane ◽  
Drug Delivery System ◽  
Lipid Bilayer ◽  
Delivery System ◽  
Phospholipid Bilayers ◽  
Theoretical Physics ◽  
Colloid Science ◽  
Preparation And Evaluation

In this article, we discussed about type, preparation and evaluation of liposomes. The term liposome means body of lipid and it basically consisting of one or more phospholipid bilayers. liposomes are a mostly useful in reproduction, reagent, and gear in various scientific regimentation, including mathematics and theoretical physics, chemistry, colloid science, biochemistry, biology etc. these are one amongst the various drug delivery system used to target the drug to particular tissue because liposomes structure similar to lipid bilayer and cell membrane.  

scholarly journals Preparation of self micro emulsifying drug delivery system(smedds) of poorly soluble drug eprosartan mesylate and its in vitro evaluation

2019 ◽  
Vol 10 (4) ◽  
pp. 3304-3314
Author(s):  
Sabitri Bindhani ◽  
Snehamayee Mohapatra ◽  
Rajat Ku. Kar ◽  
Utkalika Mahapatra
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ternary Phase Diagram ◽  
Tween 80 ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
Pure Drug

Eprosartan Mesylate (EM), an angiotensin II receptor blocker used in the treatment of high blood pressure. But poor solubility and bioavailability (13%) of eprosartan mesylate is a major challenging factor for improving its drug release rate. The main objective of the present work to develop and characterize self micro emulsifying drug delivery system of eprosartan mesylate by using compatible oil, surfactant and co-surfactant. For the selection of oil, surfactant and cosurfactant, solubility screening studies has been carried out. The nine formulations are prepared using peppermint oil, tween 80 and PEG 400. A pseudo ternary phase diagram was prepared to determine the self emulsion region. Four optimized formulations were prepared at 1:1 ratio(a mixture of surfactant and cosurfactant). These four formulations were evaluated for self-emulsification time, droplet size measurement, drug content analysis robustness to dilution test, viscosity analysis, f.t.i.r. The study and in-vitro diffusion studies. The ratio of scosmix (a mixture of surfactant and cosurfactant) of optimized formulation (pf5) was varied to pfa1 (2:1), pf2 (3:1), pfa3 (1:2) and compared with pure drug. The formulation having pfa1 (2:1) shown drug release of 93.13 % in 330 minutes where as pure drug showed a drug release of 54.51% in 330 minutes. So the prepared SMEDDS formulations were efficient and better than the pure drug, and it followed Korsmeyer pappes due to highest r2 value followed by Hixon crowel. It was concluded that incorporation of eprosartan mesylate in selfmicroemulsifying system is a great potential for improving the solubility and dissolution rate of eprosartan mesylate.

The transdermal inhibition of melanogenesis by a cell-membrane-permeable peptide delivery system based on poly-arginine

Biomaterials ◽  
2014 ◽  
Vol 35 (15) ◽  
pp. 4508-4516 ◽  
Author(s):  
Nanako Ookubo ◽  
Hiroyuki Michiue ◽  
Mizuki Kitamatsu ◽  
Maho Kamamura ◽  
Tei-ichi Nishiki ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Delivery System ◽  
Peptide Delivery ◽  
A Cell
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