Octahedral molybdenum clusters as radiosensitizers for X-ray induced photodynamic therapy

2018 ◽  
Vol 6 (26) ◽  
pp. 4301-4307 ◽  
Author(s):  
Kaplan Kirakci ◽  
Jaroslav Zelenka ◽  
Michaela Rumlová ◽  
Jiří Martinčík ◽  
Martin Nikl ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Antiproliferative Effect ◽  
Cluster Compound ◽  
X Ray ◽  
Molybdenum Clusters ◽  
Molybdenum Cluster

The nanoparticles made of the luminescent octahedral molybdenum cluster compound significantly enhance the antiproliferative effect of X-ray radiation.

X-ray Inducible Luminescence and Singlet Oxygen Sensitization by an Octahedral Molybdenum Cluster Compound: A New Class of Nanoscintillators

2015 ◽  
Vol 55 (2) ◽  
pp. 803-809 ◽  
Author(s):  
Kaplan Kirakci ◽  
Pavel Kubát ◽  
Karla Fejfarová ◽  
Jiří Martinčík ◽  
Martin Nikl ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Cluster Compound ◽  
Compound A ◽  
X Ray ◽  
New Class ◽  
Molybdenum Cluster

A Water-Soluble Octahedral Molybdenum Cluster Complex as a Potential Agent for X-Ray Induced Photodynamic Therapy

2021 ◽  
Author(s):  
Kaplan Kirakci ◽  
Tatyana Pozmogova ◽  
Andrey Y Protasevich ◽  
Georgy D Vavilov ◽  
Dmitri Stass ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Reactive Oxygen ◽  
Water Soluble ◽  
Cluster Complex ◽  
Oxygen Species ◽  
X Ray ◽  
Molybdenum Cluster

X-ray-induced photodynamic therapy (X-PDT) has recently evolved into a suitable modality to fight cancer. This technique, which exploits radiosensitizers producing reactive oxygen species, allows for a reduction of the radiation...

scholarly journals X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Xuefan Gu ◽  
Chao Shen ◽  
Hua Li ◽  
Ewa M. Goldys ◽  
Wei Deng
Keyword(s):  
Photodynamic Therapy ◽  
Delivery System ◽  
X Ray

scholarly journals X-Ray Induced Photodynamic Therapy: A Combination of Radiotherapy and Photodynamic Therapy

Theranostics ◽  
2016 ◽  
Vol 6 (13) ◽  
pp. 2295-2305 ◽  
Author(s):  
Geoffrey D. Wang ◽  
Ha T. Nguyen ◽  
Hongmin Chen ◽  
Phillip B. Cox ◽  
Lianchun Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
X Ray

Synthesis of Y2O3: Eu Luminescent Phosphor with Increased Dispersion for Use in Medical Purposes

2021 ◽  
Vol 1040 ◽  
pp. 61-67
Author(s):  
Anna B. Vlasenko ◽  
Vadim V. Bakhmetyev ◽  
Sergey V. Mjakin
Keyword(s):  
Particle Size ◽  
Photodynamic Therapy ◽  
Visible Light ◽  
Modern Method ◽  
The Body ◽  
Hydrothermal Processing ◽  
X Ray ◽  
Microwave Annealing ◽  
Body Tissues ◽  
Pyrogenic Silica

Photodynamic therapy (PDT) is a promising modern method for treatment of oncological, bacterial, fungal and viral diseases. However, its application is limited to diseases with superficial localization since the body tissues are not transparent for visible light. To address this problem and extend PDT application to abdominal diseases, an enhanced method of X-ray photodynamic therapy (XRPDT) is suggested, involving X-ray radiation easily penetrating the body tissues. The implementation of this approach requires the development of a pharmacological drug including a photosensitizer stimulated by visible light to yield active oxygen and a nanosized phosphor converting X-ray radiation into visible light with the wavelength required for the photosensitizer activation. This study is aimed at obtaining X-ray stimulated phosphors with nanosized particles suitable for XRPDT application. For this purpose, Y2O3:Eu phosphors were synthesized via hydrothermal processing of the corresponding mixed acetate followed by annealing. To prevent from the undesirable agglomeration of the particles in the course of hydrothermal synthesis and subsequent annealing, different techniques were used, including rapid thermal annealing (RTA), microwave annealing and addition of finely dispersed pyrogenic silica (aerosil) to the phosphor. The microwave annealing was carried out using a special installation including a resonance chamber for maintaining a standing wave of microwave radiation. The performed research allowed the determination of hydrothermal processing optimal duration affording the synthesis of phosphors with the highest luminescence brightness. The application of microwave annealing is found to provide phosphors with a more perfect crystal structure compared with RTA. The developed method of Y2O3:Eu phosphor synthesis involving pyrogenic silica addition to the autoclave allowed the preparation of samples with the amorphous structure and significantly reduced the particle size without a considerable decrease in the luminescence brightness. The particle size of the phosphor synthesized with aerosil addition is less than 100 nm that allows its implementation in pharmacological drugs for XRPDT.

scholarly journals Super Long Green Persistent Luminescence from X-Ray Excited β-NaYF4: Tb3+

2019 ◽  
Author(s):  
Yue Hu ◽  
Yanmin Yang ◽  
Xiaoxiao Li ◽  
Xin Wang ◽  
Yunqian Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Light Source ◽  
Green Emission ◽  
Persistent Luminescence ◽  
Tunneling Model ◽  
X Ray ◽  
Long Afterglow ◽  
Photo Stability ◽  
F Centers

Here, we have discovered a X-ray excited long afterglow phosphor β-NaYF4: Tb3+. After the irradiation of X-ray, the green emission can persist for more than 240 h. After 36 h, the afterglow intensity arrived at 0.69 mcd•m-2, which can clearly be observed by naked eyes. Even after 84 h, the afterglow emission brightness still reached 0.087 mcd•m-2. Also, combined with the results of thermoluminescence and photoluminescence, the super long afterglow emission of β-NaYF4: Tb3+ can be ascribed to the tunneling model associated with F centers. More importantly, the super long green afterglow emission of β-NaYF4: Tb3+ has been successfully used as in vivo light source to activate g-C3N4 for photodynamic therapy（PDT）and bacteria destruction. Furthermore, super long persistent luminescence of β-NaYF4: Tb3+ could be repeatedly charged by X-ray for many circulations, which indicates that the phosphors have high photo stability under repeated cycles of alternating X-ray irradiation.

Verteprofin conjugated to gold nanoparticles for fluorescent cellular bioimaging and X-ray mediated photodynamic therapy

2017 ◽  
Vol 184 (6) ◽  
pp. 1765-1771 ◽  
Author(s):  
Sandhya Clement ◽  
Wenjie Chen ◽  
Ayad G. Anwer ◽  
Ewa M. Goldys
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
X Ray

scholarly journals Rare-Earth-Doped Calcium Carbonate Exposed to X-ray Irradiation to Induce Reactive Oxygen Species for Tumor Treatment

2019 ◽  
Vol 20 (5) ◽  
pp. 1148 ◽  
Author(s):  
Chun-Chen Yang ◽  
Wei-Yun Wang ◽  
Feng-Huei Lin ◽  
Chun-Han Hou
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Growth ◽  
Light Source ◽  
Reactive Oxygen ◽  
Blood Analysis ◽  
Oxygen Species ◽  
Tumor Treatment ◽  
X Ray

Conventional photodynamic therapy (PDT) is limited by its penetration depth due to the photosensitizer and light source. In this study, we developed X-ray induced photodynamic therapy that applied X-ray as the light source to activate Ce-doped CaCO3 (CaCO3:Ce) to generate an intracellular reactive oxygen species (ROS) for killing cancer cells. The A549 cell line was used as the in vitro and in vivo model to evaluate the efficacy of X-ray-induced CaCO3:Ce. The cell viability significantly decreased and cell cytotoxicity obviously increased with CaCO3:Ce exposure under X-ray irradiation, which is less harmful than radiotherapy in tumor treatment. CaCO3:Ce produced significant ROS under X-ray irradiation and promoted A549 cancer cell death. CaCO3:Ce can enhance the efficacy of X-ray induced PDT, and tumor growth was inhibited in vivo. The blood analysis and hematoxylin and eosin stain (H&E) stain fully supported the safety of the treatment. The mechanisms underlying ROS and CO2 generation by CaCO3:Ce activated by X-ray irradiation to induce cell toxicity, thereby inhibiting tumor growth, is discussed. These findings and advances are of great importance in providing a novel therapeutic approach as an alternative tumor treatment.

scholarly journals A mini-review of X-ray photodynamic therapy (XPDT) nonoagent constituents’ safety and relevant design considerations

2020 ◽  
Vol 19 (9) ◽  
pp. 1134-1144
Author(s):  
A. Belanova ◽  
V. Chmykhalo ◽  
D. Beseda ◽  
M. Belousova ◽  
V. Butova ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
X Ray ◽  
Design Considerations

XPDT does not end with killing of cancer cells. Its effects and safety are to be tracked down to excretion.

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