A simple strategy for robust preparation and characterisation of hydrogels derived from chitosan and amino functional monomers for biomedical applications

2018 ◽  
Vol 6 (31) ◽  
pp. 5115-5129 ◽  
Author(s):  
Ferdous Khan ◽  
Fumihiro Aratsu ◽  
Shingo Kobayashi ◽  
Masaru Tanaka
Keyword(s):  
Molecular Interactions ◽  
Biomedical Applications ◽  
Stimuli Responsive ◽  
Functional Monomers ◽  
Simple Strategy ◽  
External Stimuli ◽  
Responsive Hydrogels

Molecular interactions of amino functional (AF) monomers with chitosan (CS) lead to the formation of external stimuli responsive hydrogels (HGs).

scholarly journals Weak bond-based injectable and stimuli responsive hydrogels for biomedical applications

2017 ◽  
Vol 5 (5) ◽  
pp. 887-906 ◽  
Author(s):  
Xiaochu Ding ◽  
Yadong Wang
Keyword(s):  
Biomedical Applications ◽  
Stimuli Responsive ◽  
Weak Bond ◽  
Responsive Hydrogels

Here we define hydrogels crosslinked by weak bonds as physical hydrogels.

scholarly journals An update on smart biocatalysts for industrial and biomedical applications

2018 ◽  
Vol 15 (139) ◽  
pp. 20180062 ◽  
Author(s):  
Akhilesh Kumar Shakya ◽  
Kutty Selva Nandakumar
Keyword(s):  
Biomedical Applications ◽  
Electronic Devices ◽  
External Environment ◽  
Review Article ◽  
Smart Polymers ◽  
Stimuli Responsive ◽  
Smart Polymer ◽  
External Stimuli ◽  
Enzyme Changes ◽  
Significant Attention

Recently, smart biocatalysts, where enzymes are conjugated to stimuli-responsive (smart) polymers, have gained significant attention. Based on the presence or absence of external stimuli, the polymer attached to the enzyme changes its conformation to protect the enzyme from the external environment and regulate the enzyme activity, thus acting as a molecular switch. Owing to this behaviour, smart biocatalysts can be separated easily from a reaction mixture and re-used several times. Several such smart polymer-based biocatalysts have been developed for industrial and biomedical applications. In addition, they have been used in biosensors, biometrics and nano-electronic devices. This review article covers recent advances in developing different kinds of stimuli-responsive enzyme bioconjugates, including conjugation strategies, and their applications.

scholarly journals Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

2021 ◽  
pp. 100186
Author(s):  
Hussein M. El-Husseiny ◽  
Eman A. Mady ◽  
Lina Hamabe ◽  
Amira Abugomaa ◽  
Kazumi Shimada ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Biomedical Applications ◽  
Cutting Edge ◽  
Stimuli Responsive ◽  
Responsive Hydrogels

scholarly journals Latest Advances on the Synthesis of Linear ABC-Type Triblock Terpolymers and Star-Shaped Polymers by RAFT Polymerization

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1698
Author(s):  
Athanasios Skandalis ◽  
Theodore Sentoukas ◽  
Despoina Giaouzi ◽  
Martha Kafetzi ◽  
Stergios Pispas
Keyword(s):  
Self Assembly ◽  
Raft Polymerization ◽  
Degree Of Polymerization ◽  
Stimuli Responsive ◽  
Reaction Conditions ◽  
Functional Monomers ◽  
Precise Control ◽  
Versatile Technique ◽  
External Stimuli ◽  
Triblock Terpolymers

This review article aims to cover the most recent advances regarding the synthesis of linear ABC-type triblock terpolymers and star-shaped polymers by RAFT polymerization, as well as their self-assembly properties in aqueous solutions. RAFT polymerization has received extensive attention, as it is a versatile technique, compatible with a great variety of functional monomers and reaction conditions, while providing exceptional and precise control over the final structure, with well-defined side-groups and post-polymerization engineering potential. Linear triblock terpolymers synthesis can lead to very interesting novel ideas, since there are countless combinations of stimuli/non-stimuli and hydrophilic/hydrophobic monomers that someone can use. One of their most interesting features is their ubiquitous ability to self-assemble in different nanostructures depending on their degree of polymerization (DP), block composition, solubilization protocol, internal and external stimuli. On the other hand, star-shaped polymers exhibit a more stable nanostructure, with a distinct crosslinked core and arm blocks that can also incorporate stimuli-responsive blocks for “smart” applications.

Natural Polymer-based Stimuli-responsive Hydrogels

2020 ◽  
Vol 27 (16) ◽  
pp. 2631-2657 ◽  
Author(s):  
Yuheng Jiang ◽  
Ying Wang ◽  
Qin Li ◽  
Chen Yu ◽  
Wanli Chu
Keyword(s):  
Natural Polymer ◽  
Stimuli Responsive ◽  
Medical Field ◽  
Preparation Methods ◽  
Polymer Hydrogels ◽  
Advanced Technologies ◽  
Redox Responsive ◽  
Good Biocompatibility ◽  
External Stimuli ◽  
Responsive Hydrogels

The abilities of intelligent polymer hydrogels to change their structure and volume phase in response to external stimuli have provided new possibilities for various advanced technologies and great research and application potentials in the medical field. The natural polymer-based hydrogels have the advantages of environment-friendliness, rich sources and good biocompatibility. Based on their responsiveness to external stimuli, the natural polymer-based hydrogels can be classified into the temperature-responsive hydrogel, pH-responsive hydrogel, light-responsive hydrogel, electricresponsive hydrogel, redox-responsive hydrogel, enzyme-responsive hydrogel, magnetic-responsive hydrogel, multi-responsive hydrogel, etc. In this review, we have compiled some recent studies on natural polymer-based stimuli-responsive hydrogels, especially the hydrogels prepared from polysaccharides. The preparation methods, properties and applications of these hydrogels in the medical field are highlighted.

scholarly journals Smart Supra- and Macro-Molecular Tools for Biomedical Applications

Materials ◽  
2020 ◽  
Vol 13 (15) ◽  
pp. 3343
Author(s):  
Mariana Pinteala ◽  
Marc J. M. Abadie ◽  
Radu D. Rusu
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Viral Vectors ◽  
Polymeric Materials ◽  
External Source ◽  
Stimuli Responsive ◽  
Molecular Tools ◽  
Field Function ◽  
Materials Used ◽  
External Stimuli

Stimuli-responsive, “smart” polymeric materials used in the biomedical field function in a bio-mimicking manner by providing a non-linear response to triggers coming from a physiological microenvironment or other external source. They are built based on various chemical, physical, and biological tools that enable pH and/or temperature-stimulated changes in structural or physicochemical attributes, like shape, volume, solubility, supramolecular arrangement, and others. This review touches on some particular developments on the topic of stimuli-sensitive molecular tools for biomedical applications. Design and mechanistic details are provided concerning the smart synthetic instruments that are employed to prepare supra- and macro-molecular architectures with specific responses to external stimuli. Five major themes are approached: (i) temperature- and pH-responsive systems for controlled drug delivery; (ii) glycodynameric hydrogels for drug delivery; (iii) polymeric non-viral vectors for gene delivery; (iv) metallic nanoconjugates for biomedical applications; and, (v) smart organic tools for biomedical imaging.

scholarly journals Stimuli‐responsive hydrogels: Fabrication and biomedical applications

View ◽  
2021 ◽  
pp. 20200112
Author(s):  
Ziyuan Li ◽  
Yanzi Zhou ◽  
Tianyue Li ◽  
Junji Zhang ◽  
He Tian
Keyword(s):  
Biomedical Applications ◽  
Stimuli Responsive ◽  
Responsive Hydrogels

Biomedical Applications of Stimuli-Responsive Hydrogels

2020 ◽  
pp. 1-20
Author(s):  
Anderson Ferreira Sepulveda ◽  
Roger Borges ◽  
Juliana Marchi ◽  
Daniele Ribeiro de Araujo
Keyword(s):  
Biomedical Applications ◽  
Stimuli Responsive ◽  
Responsive Hydrogels
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