Intracellular delivery of a native functional protein using cell-penetrating peptide functionalized cubic MSNs with ultra-large mesopores

2018 ◽  
Vol 6 (21) ◽  
pp. 3456-3465 ◽  
Author(s):  
Sang-Eun Bae ◽  
Soo Kyung Lyu ◽  
Ki-Jung Kim ◽  
Hee Joo Shin ◽  
Hyockman Kwon ◽  
...  
Keyword(s):  
Click Reaction ◽  
Intracellular Delivery ◽  
Cell Penetrating Peptide ◽  
Functional Protein ◽  
Native Form ◽  
Cytosolic Delivery ◽  
Cell Penetrating ◽  
A Cell ◽  
Large Mesopores

Pore-enlarged 3D cubic cMSNs were successfully prepared, and their surfaces were functionalized by a cell-penetrating R8-peptide through the click reaction for cytosolic delivery of a functional protein in its native form.

scholarly journals Codelivery of a cytotoxin and photosensitiser via a liposomal nanocarrier: a novel strategy for light-triggered cytosolic release

Nanoscale ◽  
2018 ◽  
Vol 10 (43) ◽  
pp. 20366-20376 ◽  
Author(s):  
Elnaz Yaghini ◽  
Ruggero Dondi ◽  
Karen J. Edler ◽  
Marilena Loizidou ◽  
Alexander J. MacRobert ◽  
...  
Keyword(s):  
Intracellular Delivery ◽  
Cell Penetrating Peptide ◽  
Protein Toxin ◽  
Cell Penetrating ◽  
A Cell ◽  
Novel Strategy

Light-triggered intracellular delivery of a protein toxin was achieved by codelivery via a liposomal nanocarrier, targeted with a cell-penetrating peptide (CPP)–photosensitiser conjugate.

Supramolecular intracellular delivery of an anionic porphyrin by octaarginine-conjugated per-O-methyl-β-cyclodextrin

2015 ◽  
Vol 51 (12) ◽  
pp. 2421-2424 ◽  
Author(s):  
Hiroaki Kitagishi ◽  
Fumihiko Chai ◽  
Shigeru Negi ◽  
Yukio Sugiura ◽  
Koji Kano
Keyword(s):  
Efficient Method ◽  
Intracellular Delivery ◽  
Water Soluble ◽  
Cell Penetrating Peptide ◽  
Supramolecular Interaction ◽  
Cell Penetrating ◽  
A Cell

A convenient and efficient method for intracellular delivery of a water-soluble anionic porphyrin has been developed by utilizing its supramolecular interaction with per-O-methyl-β-cyclodextrin bearing an octaarginine chain as a cell-penetrating peptide.

scholarly journals Intracellular delivery of therapeutic antisense oligonucleotides targeting mRNA coding mitochondrial proteins by cell-penetrating peptides

2020 ◽  
Vol 8 (47) ◽  
pp. 10825-10836
Author(s):  
Carmine Pasquale Cerrato ◽  
Tove Kivijärvi ◽  
Roberta Tozzi ◽  
Tõnis Lehto ◽  
Maxime Gestin ◽  
...  
Keyword(s):  
Antisense Oligonucleotides ◽  
Intracellular Delivery ◽  
Cell Penetrating Peptides ◽  
Peptide Library ◽  
Mitochondrial Proteins ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell

Development of a cell-penetrating peptide library to deliver biomolecules affecting mitochondria functionalities by targeting genes coding for mitochondrial proteins.

scholarly journals Intracellular Delivery of Short Interfering RNA in Rat Organ of Corti Using a Cell-penetrating Peptide PepFect6

2012 ◽  
Vol 1 ◽  
pp. e61 ◽  
Author(s):  
Suvarna Dash-Wagh ◽  
Stefan Jacob ◽  
Staffan Lindberg ◽  
Anders Fridberger ◽  
Ülo Langel ◽  
...  
Keyword(s):  
Organ Of Corti ◽  
Intracellular Delivery ◽  
Cell Penetrating Peptide ◽  
Short Interfering Rna ◽  
Cell Penetrating ◽  
A Cell ◽  
Interfering Rna

Intracellular delivery of a peptide nucleic acid-based hybrid of an autophagy inducing peptide with a cell-penetrating peptide

2020 ◽  
Vol 18 (10) ◽  
pp. 1978-1986
Author(s):  
Yoshiyuki Hakata ◽  
Suzuka Ishikawa ◽  
Takashi Ohtsuki ◽  
Masaaki Miyazawa ◽  
Mizuki Kitamatsu
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Peptide Nucleic Acid ◽  
Peptide Nucleic Acids ◽  
Intracellular Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell

The conjugate of autophagy-inducing peptide with cell-penetrating peptide formed by hybridization between peptide nucleic acids was delivered into cell and induced effective autophagy.

scholarly journals Copper-catalyzed click reaction on/in live cells

2017 ◽  
Vol 8 (3) ◽  
pp. 2107-2114 ◽  
Author(s):  
Siheng Li ◽  
Lin Wang ◽  
Fei Yu ◽  
Zhiling Zhu ◽  
Dema Shobaki ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Click Reaction ◽  
Live Cells ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell

A copper-catalyzed click reaction inside living mammalian cells is demonstrated with the use of a cell-penetrating peptide-tethered CuI ligand.

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