scholarly journals Biophysical investigation into the antibacterial action of modelin-5-NH2

Soft Matter ◽  
2019 ◽  
Vol 15 (20) ◽  
pp. 4215-4226 ◽  
Author(s):  
Sarah R. Dennison ◽  
Thomas Hauß ◽  
Kamal Badiani ◽  
Frederick Harris ◽  
David A. Phoenix
Keyword(s):  
Antibacterial Activity ◽  
Neutron Diffraction ◽  
Helical Structure ◽  
Antibacterial Action ◽  
Membrane Interactive

Neutron diffraction studies showed that modelin-5-CONH2has potent antibacterial activity which involves membrane interactive, tilted α-helical structure.

scholarly journals Royal Jelly Aliphatic Acids Contribute to Antimicrobial Activity of Honey

2018 ◽  
Vol 62 (1) ◽  
pp. 111-123 ◽  
Author(s):  
Walerij Isidorow ◽  
Stanisław Witkowski ◽  
Piotr Iwaniuk ◽  
Monika Zambrzycka ◽  
Izabela Swiecicka
Keyword(s):  
Fatty Acids ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Royal Jelly ◽  
Dicarboxylic Acids ◽  
Antibacterial Action ◽  
Larval Food ◽  
Nutrient Media ◽  
Minimal Inhibitory Concentrations ◽  
Aliphatic Acids

Abstract Honey is valued for its therapeutic qualities which are attributed among others to its antibacterial multifactorial properties. However, all the factors that influence these properties have not been identified. The present study is focused on the antibacterial action of fatty acids originating from royal jelly, the larval food of honeybees. Aliphatic C8-C12 acids characteristic of this bee product had previously been identified in more than fifty different samples of honey originating from seven countries and in eleven samples of Polish herbhoney. Experiments were performed to ascertain the influence of acidity on the antimicrobial activity of the acids. In acidic nutrient media all tested aliphatic hydroxyacids and unsaturated dicarboxylic acids demonstrated antibacterial action against different microbes with minimal inhibitory concentrations between 0.048 and 3.125 mM. Our results confirm that part of the antibacterial activity of honey contributes to these compounds of bee origin.

scholarly journals Is AMF inoculation an alternative to maximize the in vitro antibacterial activity of Libidibia ferrea extracts?

2021 ◽  
Vol 10 (1) ◽  
pp. e10010111435
Author(s):  
Emanuela Lima dos Santos ◽  
Brena Coutinho Muniz ◽  
Beathriz Godoy Vilela Barbosa ◽  
Marcia Maria Camargo Morais ◽  
Francineyde Alves da Silva ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Mycorrhizal Fungi ◽  
Arbuscular Mycorrhizal ◽  
First Record ◽  
Antibacterial Action ◽  
Methanolic Extracts ◽  
In Vitro Antibacterial Activity ◽  
Mycorrhizal Plants ◽  
Amf Inoculation

Arbuscular mycorrhizal fungi (AMF) are known to provide plant species with several benefits, such as an increased production of bioactive compounds. However, it is yet to be defined whether extracts of mycorrhizal plants are more efficient in vitro antibacterial actions when compared to non-mycorrhizal plants. We tested the hypothesis of whether or not, methanolic extracts of Libidibia ferrea fruits, from plants established in the field and inoculated with AMF, have higher antibacterial action when inoculated with Acaulospora longula, Claroideoglomus etunicatum or Gigaspora albida. In addition, native L. ferrea fruits collected from the Caatinga area were also tested. The extracts of L. ferrea fruits inoculated with A. longula had higher in vitro antibacterial action in relation to the extracts of fruits from non-inoculated plants (p <0.05) thus characterizing the first record of different antibacterial actions of plant extracts due to inoculation with AMF. The extracts of L. ferrea fruits inoculated with A. longula were more efficient in inhibiting growth of Gram-negative bacteria. The zone diameters of inhibition ranged from 2.48 % to 7.56 % larger than the zones of the non-inoculated L. ferrea fruit extracts. The inoculation of L. ferrea with AMF may represent an alternative way of producing fruits with different antibacterial activity.

scholarly journals Identification of Antimicrobial Peptides from the Microalgae Tetraselmis suecica (Kylin) Butcher and Bactericidal Activity Improvement

Marine Drugs ◽  
2019 ◽  
Vol 17 (8) ◽  
pp. 453 ◽  
Author(s):  
Guzmán ◽  
Wong ◽  
Román ◽  
Cárdenas ◽  
Alvárez ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Pathogenic Bacteria ◽  
Bioactive Peptides ◽  
De Novo ◽  
Helical Structure ◽  
Antimicrobial Activities ◽  
Peptide Sequence ◽  
Tetraselmis Suecica ◽  
Defense Strategies ◽  
Key Residues

The outburst of microbial resistance to antibiotics creates the need for new sources of active compounds for the treatment of pathogenic microorganisms. Marine microalgae are of particular interest in this context because they have developed tolerance and defense strategies to resist the exposure to pathogenic bacteria, viruses, and fungi in the aquatic environment. Although antimicrobial activities have been reported for some microalgae, natural algal bioactive peptides have not been described yet. In this work, acid extracts from the microalga Tetraselmis suecica with antibacterial activity were analyzed, and de novo sequences of peptides were determined. Synthetic peptides and their alanine and lysine analogs allowed identifying key residues and increasing their antibacterial activity. Additionally, it was determined that the localization of positive charges within the peptide sequence influences the secondary structure with tendency to form an alpha helical structure.

Silver-coordination polymer network combining antibacterial action and shape memory capabilities

RSC Advances ◽  
2014 ◽  
Vol 4 (61) ◽  
pp. 32276-32282 ◽  
Author(s):  
Lin Wang ◽  
Wenxi Wang ◽  
Shubin Di ◽  
Xifeng Yang ◽  
Hongmei Chen ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Coordination Polymer ◽  
Shape Memory ◽  
Memory Function ◽  
Polymer Network ◽  
Antibacterial Action

An Ag-coordination polymer network displays a shape memory function and simultaneously allows Ag ions to be released to exert an antibacterial activity.

Aminoglycoside antibiotics: Synthesis of pseudotrisaccharides derived from neamine and paromamine

1978 ◽  
Vol 56 (11) ◽  
pp. 1500-1508 ◽  
Author(s):  
Stephen Hanessian ◽  
Tomoya Ogawa ◽  
Tetsuyoshi Takamoto
Keyword(s):  
Antibacterial Activity ◽  
Amino Sugar ◽  
Aminoglycoside Antibiotics ◽  
Antibacterial Action ◽  
Selective Functionalization ◽  
Derivatives Of

Pseudotrisaccharides of paromamine having a 6-O-(β-D-ribofuranosyl) and 6-O-(α-D-arabinofuranosyl) moieties were prepared from appropriately N,O-substituted derivatives of paromamine by glycosylation reactions. Selective functionalization at C-6′ in 6-O-(β-D-ribofuranosyl)paromamine led to the corresponding neamine-containing pseudotrisaccharide. None of these semisynthetic aminoglycosides possessed antibacterial activity, although at least one of them has been shown to be a substrate for the phosphotransferases I and II. The unnatural attachment of a pentofuranosyl moiety at C-6 of the 2-deoxystreptamine unit in these pseudotrisaccharides is, therefore, detrimental to their antibacterial action, unlike amino sugar containing analogs at the same position.

Characterization of 2 linear peptides without disulfide bridges from the venom of the spider Lycosa poonaensis (Lycosidae)

2021 ◽  
Author(s):  
Alhussin M A Megaly ◽  
Yusuke Yoshimoto ◽  
Yugo Tsunoda ◽  
Masahiro Miyashita ◽  
Mohammed Abdel-Wahab ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Complex Mixture ◽  
Helical Structure ◽  
The Other ◽  
Disulfide Bridges ◽  
Bioactive Components ◽  
Activity Test ◽  
Weak Activity ◽  
Weak Antibacterial Activity

ABSTRACT Spider venom is a complex mixture of bioactive components, in which peptides play an important role by showing neurotoxicity or cytotoxicity. Disulfide-rich peptides are major components in the venom, but linear peptides without disulfide bridges are also present and often show antimicrobial activity. In this study, we analyzed the venom of the spider Lycosa poonaensis (Lycosidae) to find novel antimicrobial peptides using mass spectrometry. The result revealed that 120 out of 401 detected components were nondisulfide-bridged peptides. From them, the sequence of 2 peptides (lyp2370 and lyp1987) were determined by MS/MS analysis. The biological activity test revealed that lyp2370 has only weak antibacterial activity. On the other hand, lyp1987, which is identical to M-lycotoxin-Ls3b from the Lycosa singoriensi venom, showed significant antibacterial activity. The weak activity of lyp2370 was found to be due to the presence of a Glu residue on the hydrophilic face of its amphipathic α-helical structure.

scholarly journals THE EFFECT OF N-ACETYL-L-CYSTEINE ON BIOFILM OF VIBRIO CHOLERAE

2018 ◽  
pp. 83-87 ◽  
Author(s):  
O. V. Duvanova ◽  
B. N. Mishankin ◽  
S. V. Titova ◽  
L. A. Korneeva
Keyword(s):  
Antibacterial Activity ◽  
Drug Therapy ◽  
Vibrio Cholerae ◽  
Antibacterial Effect ◽  
Antibacterial Action ◽  
Causative Agents ◽  
Planktonic Form ◽  
El Tor ◽  
Epidemiological Significance

Aim. To study the effect of N-acetyl-L-cysteine on biofilm of V. cholerae of different sero-groups isolated from various sources and with different epidemiological significance (the presence/ absence of the ctx AB genes and tcpA). Materials and methods. Bacterial eiiltiire of Vibrio cholerae El Tor O1 and O139 serogroups were grown as biolms. We have estimated the influence of the drug N-acetyl-L-cysteine at a concentration of 0.5 - 4 mg/ml on the formation, of the formed biofilm and in planktonic form. Results. Discovered antibacterial activity of N-acetyl-L-cysteine. Noted that it was influenced as in the formation, of the already formed biofilm and the planktonic form, the representatives of the Vibrio cholerae El Tor O1 and O139 serogroups in concentrations of 2 - 4 mg/ml, showing an antibacterial effect regardless of the presence/absence of genes ctx and tcpA AB. Conclusion. Identified the antibacterial action of the drug N-acetyl-L-cysteine against biofilm of V. cholerae indicates the desirability of considering the possibility of using drug therapy in cases variety of diseases caused by causative agents II - IV groups pathogenicity.

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