The influence of roughness on stem cell differentiation using 3D printed polylactic acid scaffolds

Soft Matter ◽  
2018 ◽  
Vol 14 (48) ◽  
pp. 9838-9846 ◽  
Author(s):  
Kuan-Che Feng ◽  
Adriana Pinkas-Sarafova ◽  
Vincent Ricotta ◽  
Michael Cuiffo ◽  
Linxi Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
3D Printing ◽  
Polylactic Acid ◽  
Fused Deposition Modeling ◽  
Stem Cell Differentiation ◽  
Standard Methods ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed

With the increase in popularity of 3D printing, an important question arises as to the equivalence between devices manufactured by standard methods vs. those presenting with identical bulk specifications, but manufactured via fused deposition modeling (FDM) printing.

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

scholarly journals ANALYZING THE EFFECT OF NOZZLE DIAMETER IN FUSED DEPOSITION MODELING FOR EXTRUDING POLYLACTIC ACID USING OPEN SOURCE 3D PRINTING

2016 ◽  
Vol 78 (10) ◽  
Author(s):  
Nor Aiman Sukindar ◽  
M. K. A. Ariffin ◽  
B. T. Hang Tuah Baharudin ◽  
Che Nor Aiza Jaafar ◽  
Mohd Idris Shah Ismail
Keyword(s):  
Pressure Drop ◽  
3D Printing ◽  
Polylactic Acid ◽  
Fused Deposition Modeling ◽  
Nozzle Diameter ◽  
Optimum Range ◽  
Fused Deposition ◽  
Geometrical Error ◽  
Deposition Modeling ◽  
Printing Time

Fused deposition modeling (FDM) is one of the Rapid Prototyping (RP) technologies. The 3D Printer has been widely used in the fabrication of 3D products. One of the main issues has been to obtain a high quality for the finished parts. The present study focuses on the effect of nozzle diameter in terms of pressure drop, geometrical error as well as extrusion time. While using polylactic acid (PLA) as a material, the research was conducted using Finite Element Analysis (FEA) by manipulating the nozzle diameter, and the pressure drop along the liquefier was observed. The geometrical error and printing time were also calculated by using different nozzle diameters. Analysis shows that the diameter of the nozzle significantly affects the pressure drop along the liquefier which influences the consistency of the road width thus affecting the quality of the product’s finish. The vital aspect is minimizing the pressure drop to be as low as possible, which will lead to a good quality final product. The results from the analysis demonstrate that a 0.2 mm nozzle diameter contributes the highest pressure drop, which is not within the optimum range. In this study, by considering several factors including pressure drop, geometrical error and printing time, a 0.3 mm nozzle diameter has been suggested as being in the optimum range for extruding PLA material using open-source 3D printing. The implication of this result is valuable for a better understanding of the melt flow behavior of the PLA material and for choosing the optimum nozzle diameter for 3D printing.

Properties and applications of electrically conductive thermoplastics for additive manufacturing of sensors

2017 ◽  
Vol 84 (9) ◽  
Author(s):  
Benedikt Hampel ◽  
Samuel Monshausen ◽  
Meinhard Schilling
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Electrical Conductance ◽  
Electrically Conductive ◽  
Fused Deposition ◽  
Printing Technique ◽  
Deposition Modeling ◽  
3D Printed ◽  
3D Printing Technique ◽  
Printing Parameters

AbstractIn consequence of the growing diversity of materials in the fused deposition modeling 3D printing technique, electrically conductive materials are commercially available. In this work two filaments based on thermoplastics filled with carbon or metal nanoparticles are analyzed in terms of their electrical conductance. The printing parameters to process the materials with the 3D printer are optimized with the design of experiments (DoE) method. A model to calculate the resistance of such 3D printed structures is presented and a demonstrator as a proof of concept was 3D printed based on these results. In addition, 3D printing of capacitors is investigated.

scholarly journals Attempts to Diminish the Drawbacks of Polylactic Acid Designed for 3D/4D Printing Technology-Fused Deposition Modeling

2021 ◽  
Vol 58 (1) ◽  
pp. 142-153
Author(s):  
Doina Dimonie ◽  
Nicoleta Dragomir ◽  
Rusandica Stoica
Keyword(s):  
3D Printing ◽  
Polylactic Acid ◽  
Fused Deposition Modeling ◽  
New Materials ◽  
4D Printing ◽  
Printing Technology ◽  
Fused Deposition ◽  
New Material ◽  
Deposition Modeling ◽  
Laboratory Line

In order to improve thermal behavior and dimensional strability of polylactic acid (PLA) designed both for 3D and 4D printing technology-fused deposition modeling (FDM) using a scalable procedure, the polymer was melt compounded with additives which control the morphology by crystallization and/or reinforcing. Using the formulations which provide polylactic acid (PLA) improved thermo-mechanical properties and desired dimensional stability, the new materials were shaped, on a laboratory line, as filaments for printing technology. The selected compounds were than scaled up on a 50 kg/h compounding line into granules which prove to have good shapability as filaments for printing technology (1.85 +/- 0.05 mm diameter, required ovality, good appearance and smooth surface) and performed properly at 3D printing. The obtained results proved that functional properties of PLA can be improved by various methods so that, depending on the reached performances, the new material can be converted through printing technology into items for performance applications. The novelty of the article is related to the fact that it identifies a modifying solution for controlling the morphology of a type of PLA designed for 3D printing that already has an advanced crystallinity.

scholarly journals Effects of wood flour and MA-EPDM on the properties of fused deposition modeling 3D-printed poly lactic acid composites

BioResources ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. 7122-7138
Author(s):  
Sang-U Bae ◽  
Young-Rok Seo ◽  
Birm-June Kim ◽  
Min Lee
Keyword(s):  
Lactic Acid ◽  
3D Printing ◽  
Fused Deposition Modeling ◽  
Wood Flour ◽  
Poly Lactic Acid ◽  
Common System ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed ◽  
Material Composite

Fused deposition modeling (FDM) 3D printing technology is the most common system for polymer additive manufacturing (AM). Recent studies have been conducted to expand both the range of materials that can be used for FDM and their applications. As a filler, wood flour was incorporated into poly lactic acid (PLA) polymer to develop a biocomposite material. Composite filaments were manufactured with various wood flour contents and then successfully used for 3D printing. Morphological, mechanical, and biodegradation properties of FDM 3D-printed PLA composites were investigated. To mitigate brittleness, 5 phr of maleic anhydride grafted ethylene propylene diene monomer (MA-EPDM) was added to the composite blends, and microstructural properties of the composites were examined by scanning electron microscopy (SEM). Mechanical strength tests demonstrated that elasticity was imparted to the composites. Additionally, test results showed that the addition of wood flour to the PLA matrix promoted pore generation and further influenced the mechanical and biodegradation properties of the 3D-printed composites. An excellent effect of wood flour on the biodegradation properties of FDM 3D-printed PLA composites was observed.

scholarly journals Biomaterials: Polylactic Acid and 3D Printing Processes for Orthosis and Prosthesis

2017 ◽  
Vol 54 (1) ◽  
pp. 98-102 ◽  
Author(s):  
Roxana Miclaus ◽  
Angela Repanovici ◽  
Nadinne Roman
Keyword(s):  
3D Printing ◽  
Polylactic Acid ◽  
Medical Devices ◽  
Fused Deposition Modeling ◽  
Acrylonitrile Butadiene Styrene ◽  
Fused Deposition ◽  
The Past ◽  
Deposition Modeling ◽  
Printing Processes ◽  
Butadiene Styrene

Since the development of 3D printing, over the past decades, the domain of application has evolved significantly! Concerning the orthosis and prosthesis manufacturing, the 3D printing offers many possibilities for developing new medical devices for people with disabilities. Our paper wish to synthetize the main 3D printing methods and the biomaterial properties which can be used in orthosis and prosthesis manufacturing, like polylactic acid or acrylonitrile butadiene styrene. Fused Deposition Modeling and Stereo lithography are most used for medical devices manufacturing and usually using polylactic acid, considering the properties of this polymer and de organic componence.

scholarly journals Stabilization of Electrospun Nanofiber Mats Used for Filters by 3D Printing

Polymers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1618 ◽  
Author(s):  
Kozior ◽  
Trabelsi ◽  
Mamun ◽  
Sabantina ◽  
Ehrmann
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Water Pressure ◽  
Volume Ratio ◽  
Fused Deposition ◽  
Rigid Objects ◽  
Deposition Modeling ◽  
3D Printed ◽  
Printed Materials ◽  
Nanofiber Mats

Electrospinning is a well-known technology used to create nanofiber mats from diverse polymers and other materials. Due to their large surface-to-volume ratio, such nanofiber mats are often applied as air or water filters. Especially the latter, however, have to be mechanically highly stable, which is challenging for common nanofiber mats. One of the approaches to overcome this problem is gluing them on top of more rigid objects, integrating them in composites, or reinforcing them using other technologies to avoid damage due to the water pressure. Here, we suggest another solution. While direct 3D printing with the fused deposition modeling (FDM) technique on macroscopic textile fabrics has been under examination by several research groups for years, here we report on direct FDM printing on nanofiber mats for the first time. We show that by choosing the proper height of the printing nozzle above the nanofiber mat, printing is possible for raw polyacrylonitrile (PAN) nanofiber mats, as well as for stabilized and even more brittle carbonized material. Under these conditions, the adhesion between both parts of the composite is high enough to prevent the nanofiber mat from being peeled off the 3D printed polymer. Abrasion tests emphasize the significantly increased mechanical properties, while contact angle examinations reveal a hydrophilicity between the original values of the electrospun and the 3D printed materials.

scholarly journals 3D printing for clothing production

2020 ◽  
Vol 15 ◽  
pp. 155892502094821
Author(s):  
Tatjana Spahiu ◽  
Eriseta Canaj ◽  
Ermira Shehi
Keyword(s):  
3D Printing ◽  
Online Survey ◽  
Fused Deposition Modeling ◽  
Consumer Acceptance ◽  
Fashion Industry ◽  
3D Objects ◽  
Fused Deposition ◽  
Wide Range ◽  
Deposition Modeling ◽  
3D Printed

3D printing is a well-known technology for creating 3D objects by laying down successive layers of various materials. Among the wide range of applications, fashion industry has adapted these technologies to revolutionize their brands. But due to the unique characteristics of textiles like comfort, flexibility, and so on, attempts have been made to create similar structures as textiles. The work presented here is part of a project to create garments using fused deposition modeling as 3D printing technology. Structures with various geometries are designed and tested with different materials starting from rigid to flexible. As a result, a fully 3D printed dress is created. Selecting this dress as a model, consumer acceptance for 3D printed garments is evaluated realizing an online survey containing 100 respondents. The data gathered show that respondents have knowledge of 3D printing, its advantages and the majority of them would accept wearing a 3D printed dress.

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