Cationic double chained metallosurfactants: synthesis, aggregation, cytotoxicity, antimicrobial activity and their impact on the structure of bovine serum albumin

Soft Matter ◽  
2018 ◽  
Vol 14 (25) ◽  
pp. 5306-5318 ◽  
Author(s):  
Gurpreet Kaur ◽  
Preeti Garg ◽  
Baljinder Kaur ◽  
Ganga Ram Chaudhary ◽  
Sandeep Kumar ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Protein Binding ◽  
Bovine Serum ◽  
Metal Ion

The insertion of the metal ion into the framework of the surfactant structure enhances its aggregation and protein binding/folding/unfolding abilities.

Interaction of Cefpiramide Sodium with Bovine Serum Albumin and The Effect of Coexistent Metal Ion on The Reaction

2012 ◽  
Vol 33 (9) ◽  
pp. 1018-1024 ◽  
Author(s):  
刘保生 LIU Bao-sheng ◽  
闫潇娜 YAN Xiao-na ◽  
曹世娜 CAO Shi-na ◽  
种宝红 CHONG Bao-hong ◽  
吕运开 LV Yun-kai
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Metal Ion

Influence of D-glucose, L-α-phosphatidylcholine and bovine serum albumin on the pattern of metal ion cholate precipitation in agar gel

2001 ◽  
Vol 120 (5) ◽  
pp. A202
Author(s):  
L.M. Yang ◽  
Roger D. Soloway ◽  
Y Zhao ◽  
J.G. Wu ◽  
D.F. Xu ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Metal Ion ◽  
Agar Gel

L-A-phosphatidylcholine, D-glucose, and bovine serum albumin each modify the pattern of metal ion deoxycholate precipitation in agar gel

2000 ◽  
Vol 118 (4) ◽  
pp. A11
Author(s):  
Y. Zhao ◽  
Roger D. Soloway ◽  
L-M Yang ◽  
Y-L Cai ◽  
D-J Wang ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Metal Ion ◽  
Agar Gel

scholarly journals Transition Metal Ion Chelating of Some Coumarin Antioxidants and the Interaction with Bovine Serum Albumin

2013 ◽  
Vol 25 (4) ◽  
pp. 2265-2269
Author(s):  
Ye Zhang ◽  
Biqun Zou ◽  
Yilin Fang ◽  
Zhenghong Pan ◽  
Xianghui Yi ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Transition Metal ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Metal Ion ◽  
Transition Metal Ion

Synthesis, Characterization and Biological Studies of a Organoselenium trans-Palladium(II) Complexes

2020 ◽  
Vol 16 ◽  
Author(s):  
Ivana Raković ◽  
Jovana Bogojeski ◽  
Katarina Mladenović ◽  
Angelina Petrović ◽  
Vera Divac ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Cancer Cell Line ◽  
Colorectal Cancer Cell Line ◽  
Spectral Studies ◽  
Cytotoxic Effects ◽  
Hct 116

Background: Over the years, transition metal complexes have exhibited significant antimicrobial and antitumor activity. It all started with cisplatin discovery, but due to the large number of side effects it shows, there is a growing need to find a new metal-based compound with higher selectivity and activity on more tumors. Objectives: Two novel trans-palladium(II) complexes with organoselenium compounds as ligands, [Pd(L1)2Cl2] (L1 = 5- (phenylselanylmethyl)-dihydrofuran-2(3H)-one) and [Pd(L2)2Cl2] (L2 = 2-methyl-5-(phenylselanylmethyl)- tetrahydrofuran) were synthesized, in the text referred to as Pd-Se1 and Pd-Se2. Also, a structurally similar trans-palladium(II) complex, [Pd(L3)2Cl2] (L3= 2,2-dimethyl-3-(phenylselanylmethyl)-tetrahydro-2H-pyran ) was synthesized according to an already published work and is referred to as Pd-Se3. The interaction of synthesized complexes with DNA and bovine serum albumin were done. Also, antimicrobial activity and in vitro testing, cell viability, and cytotoxic effects of synthesized ligands and complexes on human epithelial colorectal cancer cell line HCT-116 were studied. Molecular docking simulations were performed to understand better the binding modes of the complexes reported in this paper with DNA and BSA, as well as to comprehend their antimicrobial activity. Methods: The interactions of the synthesized complexes with DNA and bovine serum albumin were done using UV-Vis and emission spectral studies as well as docking studies. Antimicrobial activity was tested by determining the minimum inhibitory concentrations (MIC) and minimum microbicidal concentration (MMC) using the resazurin microdilution plate method. Cytotoxic activity on cancer cells was studied by MTT test. Results: The Pd(II) complexes showed a significant binding affinity for calf thymus DNA and bovine serum albumin by UV-Vis and emission spectral studies. The intensity of antimicrobial activity varied with the complexes Pd-Se1 and Pd-Se3, showing significantly higher activity than the corresponding ligand. The most significant activity was shown on Pseudomo-nas aeruginosa. Under standardized laboratory conditions for in vitro testing, cell viability and cytotoxic effects of synthesized ligands and complexes were studied on human epithelial colorectal cancer cell line HCT-116, where Pd-Se2 showed some significant cytotoxic effects. Conclusion: The newly synthesized complexes have the potential to be further investigated as metallodrugs.

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