Harmonic analysis of surface instability patterns on colloidal particles

Soft Matter ◽  
2018 ◽  
Vol 14 (17) ◽  
pp. 3387-3396 ◽  
Author(s):  
Tero Kämäräinen ◽  
Mariko Ago ◽  
Jani Seitsonen ◽  
Janne Raula ◽  
Esko I. Kauppinen ◽  
...  
Keyword(s):  
Harmonic Analysis ◽  
Spherical Harmonic ◽  
Colloidal Particles ◽  
Colloidal Particle ◽  
Electron Tomography ◽  
Surface Instability ◽  
Cryo Electron Tomography ◽  
Spherical Harmonic Models ◽  
Topographical Analysis

Spectral topographical analysis of wrinkled and crumpled colloidal particle surfaces utilizing cryo-electron tomography and spherical harmonic models.

scholarly journals Determining the Patchwork Lattice of Ebola and Marburg Virus Matrix Layers Using Cryo-Electron Tomography

2021 ◽  
Vol 27 (S1) ◽  
pp. 1884-1884
Author(s):  
William Wan ◽  
Mairi Clarke ◽  
Michael Norris ◽  
Larissa Kolesnikova ◽  
Alexander Koehler ◽  
...  
Keyword(s):  
Electron Tomography ◽  
Marburg Virus ◽  
Cryo Electron Tomography

scholarly journals Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility

Science ◽  
2021 ◽  
Vol 371 (6525) ◽  
pp. eabd4914
Author(s):  
Sudarshan Gadadhar ◽  
Gonzalo Alvarez Viar ◽  
Jan Niklas Hansen ◽  
An Gong ◽  
Aleksandr Kostarev ◽  
...  
Keyword(s):  
Posttranslational Modifications ◽  
Male Fertility ◽  
Electron Tomography ◽  
Structural Basis ◽  
Cellular Functions ◽  
Flagellar Beat ◽  
Cryo Electron Tomography ◽  
Axonemal Dynein ◽  
Dynein Arms ◽  
Cilia And Flagella

Posttranslational modifications of the microtubule cytoskeleton have emerged as key regulators of cellular functions, and their perturbations have been linked to a growing number of human pathologies. Tubulin glycylation modifies microtubules specifically in cilia and flagella, but its functional and mechanistic roles remain unclear. In this study, we generated a mouse model entirely lacking tubulin glycylation. Male mice were subfertile owing to aberrant beat patterns of their sperm flagella, which impeded the straight swimming of sperm cells. Using cryo–electron tomography, we showed that lack of glycylation caused abnormal conformations of the dynein arms within sperm axonemes, providing the structural basis for the observed dysfunction. Our findings reveal the importance of microtubule glycylation for controlled flagellar beating, directional sperm swimming, and male fertility.

scholarly journals Modeling and theoretical description of magnetic hybrid materials—bridging from meso- to macro-scales

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Andreas M. Menzel ◽  
Hartmut Löwen
Keyword(s):  
Colloidal Particles ◽  
Colloidal Particle ◽  
Theoretical Description ◽  
Point Of View ◽  
Material Behavior ◽  
Theoretical Point ◽  
Mechanical Stiffness ◽  
Theoretical Approaches ◽  
Theoretical Predictions ◽  
Particle Level

Abstract Magnetic gels and elastomers consist of magnetic or magnetizable colloidal particles embedded in an elastic polymeric matrix. Outstanding properties of these materials comprise reversible changes in their mechanical stiffness or magnetostrictive distortions under the influence of external magnetic fields. To understand such types of overall material behavior from a theoretical point of view, it is essential to characterize the substances starting from the discrete colloidal particle level. It turns out that the macroscopic material response depends sensitively on the mesoscopic particle arrangement. We have utilized and developed several theoretical approaches to this end, allowing us both to reproduce experimental observations and to make theoretical predictions. Our hope is that both these paths help to further stimulate the interest in these fascinating materials.

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