Solid-phase synthesis and electrochemical pseudo-capacitance of nitrogen-atom interstitial compound Co3N

2018 ◽  
Vol 2 (6) ◽  
pp. 1178-1188 ◽  
Author(s):  
Jian-Fei Gao ◽  
Wei-Bin Zhang ◽  
Zhi-Yun Zhao ◽  
Ling-Bin Kong
Keyword(s):  
Nitrogen Atom ◽  
Electrode Material ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Interstitial Compound

This work demonstrates the first application of Co3N as an electrode material for supercapacitors.

Synthesis and Screening of A DNA-Encoded Library of Non-Peptidic Macrocycles

2020 ◽  
Author(s):  
Eric Koesema ◽  
Animesh Roy ◽  
Nicholas G. Paciaroni ◽  
Thomas Kodadek
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cell Permeability ◽  
Phase Synthesis ◽  
Protein Ligands ◽  
High Affinity ◽  
Scaffold Diversity

There is considerable interest in the development of libraries of non-peptidic macrocycles as a source of ligands for difficult targets. We report here the solid-phase synthesis of a DNA-encoded library of several hundred thousand thioether-linked macrocycles. The library was designed to be highly diverse with respect to backbone scaffold diversity and to minimize the number of amide N-H bonds, which compromise cell permeability. The utility of the library as a source of protein ligands is demonstrated through the isolation of compounds that bind streptavidin, a model target, with high affinity.

Sign in / Sign up

Export Citation Format

Share Document