scholarly journals A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA

2019 ◽  
Vol 10 (12) ◽  
pp. 3502-3513 ◽  
Author(s):  
Stuart A. Archer ◽  
Ahtasham Raza ◽  
Fabian Dröge ◽  
Craig Robertson ◽  
Alexander J. Auty ◽  
...  
Keyword(s):  
Quadruplex Dna ◽  
Imaging Probe ◽  
Dinuclear Ruthenium ◽  
Dna Imaging

A previously reported dinuclear DNA imaging probe has been converted into a phototherapeutic through the incorporation of RuII(TAP)2 fragments (TAP = 1,4,5,8-3 tetraazaphenanthrene).

Dinuclear Ruthenium(II) Complexes That Induce and Stabilise G-Quadruplex DNA

2015 ◽  
Vol 21 (10) ◽  
pp. 4008-4020 ◽  
Author(s):  
Li Xu ◽  
Xiang Chen ◽  
Jingheng Wu ◽  
Jinquan Wang ◽  
Liangnian Ji ◽  
...  
Keyword(s):  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dinuclear Ruthenium

A dinuclear ruthenium(II) complex as an inducer and potential luminescent switch-on probe for G-quadruplex DNA

2018 ◽  
Vol 43 (6) ◽  
pp. 539-548
Author(s):  
Huaqian Zhao ◽  
Xuexue Xu ◽  
Shuang Wang ◽  
Yaxuan Mi ◽  
Zebao Zheng ◽  
...  
Keyword(s):  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dinuclear Ruthenium

scholarly journals Correction: A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA

2020 ◽  
Vol 11 (9) ◽  
pp. 2566-2566
Author(s):  
Stuart A. Archer ◽  
Ahtasham Raza ◽  
Fabian Dröge ◽  
Craig Robertson ◽  
Alexander J. Auty ◽  
...  
Keyword(s):  
Quadruplex Dna ◽  
Dinuclear Ruthenium

Correction for ‘A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA’ by Stuart A. Archer et al., Chem. Sci., 2019, 10, 3502–3513.

Inducement and stabilization of G-quadruplex DNA by a thiophene-containing dinuclear ruthenium(II) complex

2017 ◽  
Vol 70 (12) ◽  
pp. 2094-2112 ◽  
Author(s):  
Xiao-Long Zhao ◽  
Hua-Qian Zhao ◽  
Xue-Xue Xu ◽  
Zhen-Sheng Li ◽  
Ke-Zhi Wang
Keyword(s):  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dinuclear Ruthenium

Development of in situ Imaging Probe for Surgical Operation of Deep Brain Stimulation

2011 ◽  
Vol 131 (12) ◽  
pp. 427-428
Author(s):  
Toshihiko Noda ◽  
Pan Yi-Li ◽  
Ayato Tagawa ◽  
Takuma Kobayashi ◽  
Kiyotaka Sasagawa ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Surgical Operation ◽  
Imaging Probe ◽  
Deep Brain ◽  
In Situ Imaging

1969-P: Time-Based Internalized Characterization of Exendin-4-Based Glucagon-Like Peptide-1 Receptor-Targeting Imaging Probe

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1969-P
Author(s):  
TAKAAKI MURAKAMI ◽  
HIROYUKI FUJIMOTO ◽  
NAOTAKA FUJITA ◽  
KEITA HAMAMATSU ◽  
JUNJI FUJIKURA ◽  
...  
Keyword(s):  
Receptor Targeting ◽  
Imaging Probe ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Hybrid Imidazole-Pyridine Derivatives: An Approach to Novel Anticancer DNA Intercalators

2020 ◽  
Vol 27 (1) ◽  
pp. 154-169 ◽  
Author(s):  
Claudiu N. Lungu ◽  
Bogdan Ionel Bratanovici ◽  
Maria Mirabela Grigore ◽  
Vasilichia Antoci ◽  
Ionel I. Mangalagiu
Keyword(s):  
Experimental Data ◽  
Antimicrobial Properties ◽  
Qsar Model ◽  
Therapeutic Effectiveness ◽  
Computational Results ◽  
Pyridine Derivatives ◽  
Quadruplex Dna ◽  
Dna Intercalators ◽  
Structure Activity ◽  
G Quadruplex

Lack of specificity and subsequent therapeutic effectiveness of antimicrobial and antitumoral drugs is a common difficulty in therapy. The aim of this study is to investigate, both by experimental and computational methods, the antitumoral and antimicrobial properties of a series of synthesized imidazole-pyridine derivatives. Interaction with three targets was discussed: Dickerson-Drew dodecamer (PDB id 2ADU), G-quadruplex DNA string (PDB id 2F8U) and DNA strain in complex with dioxygenase (PDB id 3S5A). Docking energies were computed and represented graphically. On them, a QSAR model was developed in order to further investigate the structure-activity relationship. Results showed that synthesized compounds have antitumoral and antimicrobial properties. Computational results agreed with the experimental data.

Emerging Role of G-quadruplex DNA as Target in Anticancer Therapy

2017 ◽  
Vol 22 (44) ◽  
pp. 6612-6624 ◽  
Author(s):  
Graziella Cimino-Reale ◽  
Nadia Zaffaroni ◽  
Marco Folini
Keyword(s):  
Anticancer Therapy ◽  
Quadruplex Dna ◽  
G Quadruplex
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