scholarly journals Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein

2019 ◽  
Vol 10 (8) ◽  
pp. 2489-2500 ◽  
Author(s):  
Dilraj Lama ◽  
Anne-Marie Liberatore ◽  
Yuri Frosi ◽  
Jessica Nakhle ◽  
Natia Tsomaia ◽  
...  
Keyword(s):  
Translation Initiation ◽  
Translation Initiation Factor ◽  
Binding Kinetics ◽  
Initiation Factor ◽  
Stapled Peptides ◽  
Eukaryotic Translation Initiation Factor ◽  
Eukaryotic Translation ◽  
Eukaryotic Translation Initiation ◽  
Kinetics Of ◽  
Structural Insights

We have revealed a non-canonical recognition feature that can modulate the binding kinetics of hydrocarbon stapled-peptides interactions with the eIF4E protein.

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