scholarly journals Simultaneous multiple single nucleotide polymorphism detection based on click chemistry combined with DNA-encoded probes

2018 ◽  
Vol 9 (13) ◽  
pp. 3335-3340 ◽  
Author(s):  
Qian-Yu Zhou ◽  
Fang Yuan ◽  
Xiao-Hui Zhang ◽  
Ying-Lin Zhou ◽  
Xin-Xiang Zhang
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Click Reaction ◽  
High Sensitivity ◽  
Dna Ligase ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide Polymorphism Detection ◽  
Single Nucleotide ◽  
Polymorphism Detection ◽  
Novel Strategy ◽  
Dna Template

A novel strategy utilizing a DNA template-directed CuAAC click reaction to mimic a ligation reaction based on DNA ligase was successfully established for multiple SNP detection with high sensitivity and specificity.

scholarly journals Facile functionalization of peptide nucleic acids (PNAs) for antisense and single nucleotide polymorphism detection

2017 ◽  
Vol 15 (32) ◽  
pp. 6710-6714 ◽  
Author(s):  
Digvijay Gahtory ◽  
Merita Murtola ◽  
Maarten M. J. Smulders ◽  
Tom Wennekes ◽  
Han Zuilhof ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide Polymorphism Detection ◽  
Single Nucleotide ◽  
Polymorphism Detection ◽  
Detection Strategies

In this report, we show how a convenient on-resin copper-click functionalization of azido-functionalized peptide nucleic acids (PNAs) allows various PNA-based detection strategies.

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