scholarly journals An autonomous microreactor platform for the rapid identification of kinetic models

2019 ◽  
Vol 4 (9) ◽  
pp. 1623-1636 ◽  
Author(s):  
Conor Waldron ◽  
Arun Pankajakshan ◽  
Marco Quaglio ◽  
Enhong Cao ◽  
Federico Galvanin ◽  
...  
Keyword(s):  
Design Of Experiments ◽  
Kinetic Parameters ◽  
High Precision ◽  
Kinetic Models ◽  
Rapid Identification ◽  
Rapid Estimation ◽  
Model Based

Rapid estimation of kinetic parameters with high precision is facilitated by automation combined with online Model-Based Design of Experiments.

scholarly journals Model-based design of transient flow experiments for the identification of kinetic parameters

2020 ◽  
Vol 5 (1) ◽  
pp. 112-123 ◽  
Author(s):  
Conor Waldron ◽  
Arun Pankajakshan ◽  
Marco Quaglio ◽  
Enhong Cao ◽  
Federico Galvanin ◽  
...  
Keyword(s):  
Design Of Experiments ◽  
Kinetic Parameters ◽  
Transient Flow ◽  
Model Based ◽  
Precise Estimation ◽  
Flow Experiments

Rapid and precise estimation of kinetic parameters is facilitated by transient flow experiments designed using model-based design of experiments.

Model-based Control Techniques for Large-Scale High-Precision Stage

2020 ◽  
Vol 140 (4) ◽  
pp. 272-280
Author(s):  
Wataru Ohnishi ◽  
Hiroshi Fujimoto ◽  
Koichi Sakata
Keyword(s):  
High Precision ◽  
Large Scale ◽  
Model Based Control ◽  
Precision Stage ◽  
Control Techniques ◽  
Model Based

scholarly journals Variability in Estimated Modelled Insulin Secretion

2021 ◽  
pp. 193229682199112
Author(s):  
Jennifer J. Ormsbee ◽  
Hannah J. Burden ◽  
Jennifer L. Knopp ◽  
J. Geoffrey Chase ◽  
Rinki Murphy ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Kinetic Parameters ◽  
Pancreatic Beta Cells ◽  
Compartment Model ◽  
Interquartile Range ◽  
Cumulative Distribution ◽  
Model Framework ◽  
Intravenous Glucose ◽  
C Peptide ◽  
Model Based

Background: The ability to measure insulin secretion from pancreatic beta cells and monitor glucose-insulin physiology is vital to current health needs. C-peptide has been used successfully as a surrogate for plasma insulin concentration. Quantifying the expected variability of modelled insulin secretion will improve confidence in model estimates. Methods: Forty-three healthy adult males of Māori or Pacific peoples ancestry living in New Zealand participated in an frequently sampled, intravenous glucose tolerance test (FS-IVGTT) with an average age of 29 years and a BMI of 33 kg/m2. A 2-compartment model framework and standardized kinetic parameters were used to estimate endogenous pancreatic insulin secretion from plasma C-peptide measurements. Monte Carlo analysis (N = 10 000) was then used to independently vary parameters within ±2 standard deviations of the mean of each variable and the 5th and 95th percentiles determined the bounds of the expected range of insulin secretion. Cumulative distribution functions (CDFs) were calculated for each subject for area under the curve (AUC) total, AUC Phase 1, and AUC Phase 2. Normalizing each AUC by the participant’s median value over all N = 10 000 iterations quantifies the expected model-based variability in AUC. Results: Larger variation is found in subjects with a BMI > 30 kg/m2, where the interquartile range is 34.3% compared to subjects with a BMI ≤ 30 kg/m2 where the interquartile range is 24.7%. Conclusions: Use of C-peptide measurements using a 2-compartment model and standardized kinetic parameters, one can expect ~±15% variation in modelled insulin secretion estimates. The variation should be considered when applying this insulin secretion estimation method to clinical diagnostic thresholds and interpretation of model-based analyses such as insulin sensitivity.

Model-based analysis of coupled equilibrium-kinetic processes: indirect kinetic studies of thermodynamic parameters using the dynamic data

The Analyst ◽  
2015 ◽  
Vol 140 (9) ◽  
pp. 3121-3135
Author(s):  
Fereshteh Emami ◽  
Marcel Maeder ◽  
Hamid Abdollahi
Keyword(s):  
Kinetic Model ◽  
Thermodynamic Parameters ◽  
Kinetic Models ◽  
Kinetic Studies ◽  
Dynamic Data ◽  
Model Based ◽  
Kinetic Processes ◽  
Model Based Analysis

Schematic of intertwined equilibrium-kinetic model at time = 0,1,2…T when both equilibrium and kinetic models are solved explicitly.

scholarly journals High-precision measurements of cementless acetabular components using model-based RSA: An experimental study

2007 ◽  
Vol 78 (4) ◽  
pp. 463-469 ◽  
Author(s):  
Thomas Baad-Hansen ◽  
Søren Kold ◽  
Bart L Kaptein ◽  
Kjeld Søballe
Keyword(s):  
Experimental Study ◽  
High Precision ◽  
Precision Measurements ◽  
Model Based ◽  
Acetabular Components
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