scholarly journals Correction: Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation

RSC Advances ◽  
2018 ◽  
Vol 8 (50) ◽  
pp. 28745-28745
Author(s):  
Qiong-Hui Huang ◽  
Xue Wu ◽  
Xiao-Hong Chen ◽  
Jia-Zhen Wu ◽  
Zi-Ren Su ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Lipid Accumulation ◽  
Acute Liver Injury ◽  
Pogostemon Cablin

Correction for ‘Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation’ by Qiong-Hui Huang et al., RSC Adv., 2018, 8, 24399–24410.

scholarly journals Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation

RSC Advances ◽  
2018 ◽  
Vol 8 (43) ◽  
pp. 24399-24410 ◽  
Author(s):  
Qiong-Hui Huang ◽  
Xue Wu ◽  
Xiao-Hong Chen ◽  
Jia-Zhen Wu ◽  
Zi-Ren Su ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alcohol Consumption ◽  
Liver Injury ◽  
Lipid Accumulation ◽  
Hepatic Injury ◽  
Acute Liver Injury ◽  
Metabolic Disturbance ◽  
Excessive Alcohol Consumption ◽  
Pogostemon Cablin ◽  
Excessive Alcohol

Excessive alcohol consumption can cause serious hepatic injury which is associated with oxidative stress and fatty metabolic disturbance.

Sinomenine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress, inflammation and apoptosis in mice

2021 ◽  
pp. 112759
Author(s):  
Hui Fan ◽  
Tingting Tu ◽  
Xiao Zhang ◽  
Qiankun Yang ◽  
Jinxin Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Acute Liver Injury

scholarly journals The Late-Stage Protective Effect of Mito-TEMPO against Acetaminophen-Induced Hepatotoxicity in Mouse and Three-Dimensional Cell Culture Models

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 965
Author(s):  
Mohammad Abdullah-Al-Shoeb ◽  
Kenta Sasaki ◽  
Saori Kikutani ◽  
Nanami Namba ◽  
Keiichi Ueno ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Culture ◽  
Liver Injury ◽  
Protective Effect ◽  
Acute Liver Injury ◽  
Three Dimensional ◽  
3D Cell Culture ◽  
Cell Culture Model ◽  
Culture Model ◽  
Apap Hepatotoxicity

An overdose of acetaminophen (APAP), the most common cause of acute liver injury, induces oxidative stress that subsequently causes mitochondrial impairment and hepatic necroptosis. N-acetyl-L-cysteine (NAC), the only recognized drug against APAP hepatotoxicity, is less effective the later it is administered. This study evaluated the protective effect of mitochondria-specific Mito-TEMPO (Mito-T) on APAP-induced acute liver injury in C57BL/6J male mice, and a three dimensional (3D)-cell culture model containing the human hepatoblastoma cell line HepG2. The administration of Mito-T (20 mg/kg, i.p.) 1 h after APAP (400 mg/kg, i.p.) injection markedly attenuated the APAP-induced elevated serum transaminase activity and hepatic necrosis. However, Mito-T treatment did not affect key factors in the development of APAP liver injury including the activation of c-jun N-terminal kinases (JNK), and expression of the transcription factor C/EBP homologous protein (CHOP) in the liver. However, Mito-T significantly reduced the APAP-induced increase in the hepatic oxidative stress marker, nitrotyrosine, and DNA fragmentation. Mito-T markedly attenuated cytotoxicity induced by APAP in the HepG2 3D-cell culture model. Moreover, liver regeneration after APAP hepatotoxicity was not affected by Mito-T, demonstrated by no changes in proliferating cell nuclear antigen formation. Therefore, Mito-T was hepatoprotective at the late-stage of APAP overdose in mice.

scholarly journals M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury

2015 ◽  
Vol 78 ◽  
pp. 66-81 ◽  
Author(s):  
Nathalie H. Urrunaga ◽  
Ravirajsinh N. Jadeja ◽  
Vikrant Rachakonda ◽  
Daniel Ahmad ◽  
Leon P. McLean ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Liver Injury ◽  
Muscarinic Receptors ◽  
Acute Liver Injury ◽  
Oxidative Stress Response ◽  
M1 Muscarinic ◽  
M1 Muscarinic Receptors
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