scholarly journals Molecular design principles towards exo-exclusive Diels–Alder reactions

RSC Advances ◽  
2019 ◽  
Vol 9 (13) ◽  
pp. 7246-7250
Author(s):  
Ci-Jhang Huang ◽  
Elise Y. Li
Keyword(s):  
Molecular Design ◽  
Thermal Conditions ◽  
Design Principles ◽  
Diels Alder

Exo-exclusive stereoselectivity for simple, terminal-substituted dienes and dienophiles may be achieved under thermal conditions through a delicate control of substituent identities.

Molecular design principles of ionic liquids with a sulfonyl fluoride moiety

2021 ◽  
Vol 45 (5) ◽  
pp. 2443-2452 ◽  
Author(s):  
David J. Siegel ◽  
Grace I. Anderson ◽  
Noah Cyr ◽  
Daniel S. Lambrecht ◽  
Matthias Zeller ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Molecular Design ◽  
Design Principles ◽  
New Family ◽  
Sulfonyl Fluoride

New family of SO2F-functionalized ionic liquids.

scholarly journals Peptide-based coacervates as biomimetic protocells

2021 ◽  
Vol 50 (6) ◽  
pp. 3690-3705
Author(s):  
Manzar Abbas ◽  
Wojciech P. Lipiński ◽  
Jiahua Wang ◽  
Evan Spruijt
Keyword(s):  
Phase Separation ◽  
Molecular Design ◽  
Design Principles ◽  
Peptide Derivatives

This tutorial review describes molecular design principles for peptides and peptide derivatives undergoing phase separation and highlights the potential of the resulting coacervate protocells.

scholarly journals Hetero-Diels–Alder reactions of hetaryl and aryl thioketones with acetylenic dienophiles

2015 ◽  
Vol 11 ◽  
pp. 576-582 ◽  
Author(s):  
Grzegorz Mlostoń ◽  
Paulina Grzelak ◽  
Maciej Mikina ◽  
Anthony Linden ◽  
Heinz Heimgartner
Keyword(s):  
High Pressure ◽  
Room Temperature ◽  
Thermal Conditions ◽  
Alder Reaction ◽  
Diels Alder ◽  
Hydrogen Shift ◽  
Diels Alder Reaction ◽  
Shift Sequence

Selected hetaryl and aryl thioketones react with acetylenecarboxylates under thermal conditions in the presence of LiClO4 or, alternatively, under high-pressure conditions (5 kbar) at room temperature yielding thiopyran derivatives. The hetero-Diels–Alder reaction occurs in a chemo- and regioselective manner. The initially formed [4 + 2] cycloadducts rearrange via a 1,3-hydrogen shift sequence to give the final products. The latter were smoothly oxidized by treatment with mCPBA to the corresponding sulfones.

scholarly journals Atoms to Phenotypes: Molecular Design Principles of Cellular Energy Metabolism

Cell ◽  
2019 ◽  
Vol 179 (5) ◽  
pp. 1098-1111.e23 ◽  
Author(s):  
Abhishek Singharoy ◽  
Christopher Maffeo ◽  
Karelia H. Delgado-Magnero ◽  
David J.K. Swainsbury ◽  
Melih Sener ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Molecular Design ◽  
Design Principles ◽  
Cellular Energy ◽  
Cellular Energy Metabolism

Decoding the Molecular Design Principles Underlying Ca2+ Binding to βγ-Crystallin Motifs

2012 ◽  
Vol 415 (1) ◽  
pp. 75-91 ◽  
Author(s):  
Amita Mishra ◽  
Shashi Kumar Suman ◽  
Shanti Swaroop Srivastava ◽  
Rajan Sankaranarayanan ◽  
Yogendra Sharma
Keyword(s):  
Molecular Design ◽  
Design Principles

Following the rules to foil Gram-negative infections

2020 ◽  
Vol 12 (546) ◽  
pp. eabc8938
Author(s):  
Justin T. Baca
Keyword(s):  
Molecular Design ◽  
Design Principles ◽  
Multidrug Resistant ◽  
Gram Negative Bacteria ◽  
Gram Negative

Molecular design principles increase accumulation of an antibiotic in multidrug resistant Gram-negative bacteria.

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