The graviola impact on human astroglioma cells: functional significance of MUDENG

Judy Gopal; Yoon-Mi Lee; Juhyun Shin; Manikandan Muthu; Seunghwa Jung; Somi Jeong; Jeongheon Oh; Jae-Wook Oh

doi:10.1039/c8ra10039j

The graviola impact on human astroglioma cells: functional significance of MUDENG

RSC Advances ◽

10.1039/c8ra10039j ◽

2019 ◽

Vol 9 (16) ◽

pp. 8935-8942 ◽

Cited By ~ 3

Author(s):

Judy Gopal ◽

Yoon-Mi Lee ◽

Juhyun Shin ◽

Manikandan Muthu ◽

Seunghwa Jung ◽

...

Keyword(s):

Functional Significance ◽

Human Cancers ◽

Tropical Plant ◽

Astroglioma Cells

Graviola (Annona muricate) is a coveted tropical plant that has been found to be effective against many human cancers.

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Functional significance of preserved color patterns of mollusks from the Gosport Sand (Eocene) of Alabama

Journal of Paleontology ◽

10.1017/s0022336000058911 ◽

1988 ◽

Vol 62 (01) ◽

pp. 83-87 ◽

Cited By ~ 4

Author(s):

Patricia H. Kelley ◽

Charles T. Swann

Keyword(s):

Functional Morphology ◽

Functional Significance ◽

Intraspecific Variability ◽

Color Pattern ◽

Color Patterns ◽

Historical Factors ◽

Life Mode ◽

Molluscan Fauna ◽

Excellent Preservation ◽

Architectural Constraints

The excellent preservation of the molluscan fauna from the Gosport Sand (Eocene) at Little Stave Creek, Alabama, has made it possible to describe the preserved color patterns of 15 species. In this study the functional significance of these color patterns is tested in the context of the current adaptationist controversy. The pigment of the color pattern is thought to be a result of metabolic waste disposal. Therefore, the presence of the pigment is functional, although the patterns formed by the pigment may or may not have been adaptive. In this investigation the criteria proposed by Seilacher (1972) for testing the functionality of color patterns were applied to the Gosport fauna and the results compared with life mode as interpreted from knowledge of extant relatives and functional morphology. Using Seilacher's criteria of little ontogenetic and intraspecific variability, the color patterns appear to have been functional. However, the functional morphology studies indicate an infaunal life mode which would preclude functional color patterns. Particular color patterns are instead interpreted to be the result of historical factors, such as multiple adaptive peaks or random fixation of alleles, or of architectural constraints including possibly pleiotropy or allometry. The low variability of color patterns, which was noted within species and genera, suggests that color patterns may also serve a useful taxonomic purpose.

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Complex Vesicles, Microtubules, and Cytoplasmic Filaments in the Endothelial Cells of Normal Dog Aorta

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100100603 ◽

1968 ◽

Vol 26 ◽

pp. 172-173

Author(s):

C. N. Sun ◽

J. J. Ghidoni

Keyword(s):

Electron Microscopy ◽

Endothelial Cells ◽

Cross Sections ◽

Functional Significance ◽

Tubular Structures ◽

Aldehyde Fixation ◽

Cytoplasmic Filaments

Endothelial cells in longitudinal and cross sections of aortas from 3 randomly selected “normal” mongrel dogs were studied by electron microscopy. Segments of aorta were distended with cold cacodylate buffered 5% glutaraldehyde for 10 minutes prior to being cut into small, well oriented tissue blocks. After an additional 1-1/2 hour period in glutaraldehyde, the tissue blocks were well rinsed in buffer and post-fixed in OsO4. After dehydration they were embedded in a mixture of Maraglas, D.E.R. 732, and DDSA.Aldehyde fixation preserves the filamentous and tubular structures (300 Å and less) for adequate demonstration and study. The functional significance of filaments and microtubules has been recently discussed by Buckley and Porter; the precise roles of these cytoplasmic components remains problematic. Endothelial cells in canine aortas contained an abundance of both types of structures.

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