scholarly journals Near-infrared emitting lanthanide(iii) complexes as prototypes of optical imaging agents with peptide targeting ability: a methodological approach

RSC Advances ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 1747-1751 ◽  
Author(s):  
Monika Cieslikiewicz-Bouet ◽  
Svetlana V. Eliseeva ◽  
Vincent Aucagne ◽  
Agnès F. Delmas ◽  
Isabelle Gillaizeau ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Azo Dye ◽  
Near Infrared ◽  
Methodological Approach ◽  
Imaging Agents ◽  
Targeting Ability ◽  
Peptide Targeting

NIR Ln(iii) complexes combining a cyclen derivative, azo-dye as a sensitizer and a cRGD peptide as a targeting moiety.

scholarly journals Radiolabeled Silicon-Rhodamines as Bimodal PET/SPECT-NIR Imaging Agents

2021 ◽  
Vol 14 (11) ◽  
pp. 1155
Author(s):  
Thines Kanagasundaram ◽  
Markus Laube ◽  
Johanna Wodtke ◽  
Carsten Sven Kramer ◽  
Sven Stadlbauer ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Near Infrared ◽  
Fluorescent Dyes ◽  
Single Photon ◽  
Photon Emission ◽  
Quantum Yields ◽  
Imaging Agents ◽  
Emission Computed Tomography ◽  
Bimodal Imaging ◽  
Nir Imaging

Radiolabeled fluorescent dyes are decisive for bimodal imaging as well as highly in demand for nuclear- and optical imaging. Silicon-rhodamines (SiRs) show unique near-infrared (NIR) optical properties, large quantum yields and extinction coefficients as well as high photostability. Here, we describe the synthesis, characterization and radiolabeling of novel NIR absorbing and emitting fluorophores from the silicon-rhodamine family for use in optical imaging (OI) combined with positron emission tomography (PET) or single photon emission computed tomography (SPECT), respectively. The presented photostable SiRs were characterized using NMR-, UV-Vis-NIR-spectroscopy and mass spectrometry. Moreover, the radiolabeling conditions using fluorine-18 or iodine-123 were extensively explored. After optimization, the radiofluorinated NIR imaging agents were obtained with radiochemical conversions (RCC) up to 70% and isolated radiochemical yields (RCY) up to 54% at molar activities of g.t. 70 GBq/µmol. Radioiodination delivered RCCs over 92% and allowed to isolate the 123I-labeled product in RCY of 54% at a molar activity of g.t. 7.6 TBq/µmol. The radiofluorinated SiRs exhibit in vitro stabilities g.t. 70% after two hours in human serum. The first described radiolabeled SiRs are a promising step toward their further development as multimodal PET/SPECT-NIR imaging agents for planning and subsequent imaging-guided oncological surgery.

scholarly journals Targeted Optical Imaging Agents in Cancer: Focus on Clinical Applications

2018 ◽  
Vol 2018 ◽  
pp. 1-19 ◽  
Author(s):  
Bishnu P. Joshi ◽  
Thomas D. Wang
Keyword(s):  
Optical Imaging ◽  
Cancer Detection ◽  
Near Infrared ◽  
Expression Patterns ◽  
Fluorescence Labeling ◽  
Imaging Agents ◽  
Wide Range ◽  
Molecular Specificity ◽  
Molecular Expression

Molecular imaging is an emerging strategy for in vivo visualization of cancer over time based on biological mechanisms of disease activity. Optical imaging methods offer a number of advantages for real-time cancer detection, particularly in the epithelium of hollow organs and ducts, by using a broad spectral range of light that spans from visible to near-infrared. Targeted ligands are being developed for improved molecular specificity. These platforms include small molecule, peptide, affibody, activatable probes, lectin, and antibody. Fluorescence labeling is used to provide high image contrast. This emerging methodology is clinically useful for early cancer detection by identifying and localizing suspicious lesions that may not otherwise be seen and serves as a guide for tissue biopsy and surgical resection. Visualizing molecular expression patterns may also be useful to determine the best choice of therapy and to monitor efficacy. A number of these imaging agents are overcoming key challenges for clinical translation and are being validated in vivo for a wide range of human cancers.

scholarly journals Tri-functional platform for construction of modular antibody fragments for in vivo18F-PET or NIRF molecular imaging

2020 ◽  
Vol 11 (7) ◽  
pp. 1832-1838
Author(s):  
Raymond F. Gamache ◽  
Kirstin A. Zettlitz ◽  
Wen-Ting K. Tsai ◽  
Jeffrey Collins ◽  
Anna M. Wu ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Optical Imaging ◽  
Targeted Delivery ◽  
Antibody Fragments ◽  
Imaging Agents ◽  
Universal Approach

To provide a universal approach towards the targeted delivery of PET and optical imaging agents, we have developed a tri-functional platform (TFP) for the facile construction of modular, target-specific tracers.

scholarly journals Micelle-based activatable probe for in vivo near-infrared optical imaging of cancer biomolecules

2014 ◽  
Vol 10 (1) ◽  
pp. 187-195 ◽  
Author(s):  
Yoichi Shimizu ◽  
Takashi Temma ◽  
Isao Hara ◽  
Akira Makino ◽  
Ryo Yamahara ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Near Infrared ◽  
Activatable Probe

scholarly journals Assessment of Endothelin-A Receptor Expression in Subcutaneous and Orthotopic Thyroid Carcinoma Xenografts in Vivo Employing Optical Imaging Methods

Endocrinology ◽  
2012 ◽  
Vol 153 (6) ◽  
pp. 2907-2918 ◽  
Author(s):  
Katrin Büther ◽  
Matthijs G. Compeer ◽  
Jo G. R. De Mey ◽  
Otmar Schober ◽  
Michael Schäfers ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Optical Imaging ◽  
Near Infrared ◽  
Functional Performance ◽  
Thyroid Tumor ◽  
Receptor Expression ◽  
Imaging Methods ◽  
Carcinoma Cell Lines ◽  
Isolated Artery

Endothelin (ET) receptor dysregulation has been described in a number of pathophysiological processes, including cardiovascular disorders, renal failure, and cancer. The aim of this study was to evaluate the expression of the ET-A receptor (ETAR) in murine models of thyroid carcinoma using optical imaging methods. A recently developed near-infrared fluorescent tracer was first assessed in isolated artery preparations for its functional performance in comparison with known ETAR antagonists BQ123 and PD156707. Before evaluation of the tracer in vivo, different thyroid carcinoma cell lines were characterized with respect to their ET receptor expression by RT-PCR and autoradiography. In vivo, sc and orthotopic papillary thyroid tumor xenografts were clearly visualized by fluorescence reflectance imaging and fluorescence-mediated tomography up to 48 h after injection of the tracer. Binding specificity of the probe was demonstrated by predosing with PD156707 as a competing inhibitor. In conclusion, optical imaging with a fluorescent ETAR tracer allows the noninvasive imaging of tumor-associated ETAR expression in vivo. In the future, this technique may help surgeons to evaluate lesion dimensions in intraoperative settings (e.g. thyroidectomy).

Gold nanoparticle-enhanced near infrared fluorescent nanocomposites for targeted bio-imaging

RSC Advances ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Hao Cheng ◽  
Chuanxi Wang ◽  
Zhenzhu Xu ◽  
Huihui Lin ◽  
Chi Zhang
Keyword(s):  
Folic Acid ◽  
Cancer Cells ◽  
Gold Nanoparticle ◽  
Near Infrared ◽  
Water Solubility ◽  
Imaging Agents ◽  
Nir Fluorescence ◽  
Target Imaging ◽  
Bio Imaging ◽  
Low Toxicity

Folic acid-conjugated nanocomposites with NIR fluorescence, water-solubility, and low toxicity are prepared and used as target-imaging agents for cancer cells.

scholarly journals Role of Fluorophore Charge on the In Vivo Optical Imaging Properties of Near-Infrared Cyanine Dye/Monoclonal Antibody Conjugates

2015 ◽  
Vol 27 (2) ◽  
pp. 404-413 ◽  
Author(s):  
Kazuhide Sato ◽  
Alexander P. Gorka ◽  
Tadanobu Nagaya ◽  
Megan S. Michie ◽  
Roger R. Nani ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Optical Imaging ◽  
Near Infrared ◽  
Cyanine Dye ◽  
Antibody Conjugates ◽  
Imaging Properties ◽  
In Vivo Optical Imaging

scholarly journals Correction: Optical imaging of ovarian cancer using a matrix metalloproteinase-3-sensitive near-infrared fluorescent probe

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0202610
Author(s):  
Kuo-Hwa Wang ◽  
Yun-Ming Wang ◽  
Li-Hsuan Chiu ◽  
Tze-Chien Chen ◽  
Yu-Hui Tsai ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Matrix Metalloproteinase ◽  
Optical Imaging ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Matrix Metalloproteinase 3

scholarly journals Targeted zwitterionic near-infrared fluorophores for improved optical imaging

2013 ◽  
Vol 31 (2) ◽  
pp. 148-153 ◽  
Author(s):  
Hak Soo Choi ◽  
Summer L Gibbs ◽  
Jeong Heon Lee ◽  
Soon Hee Kim ◽  
Yoshitomo Ashitate ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Near Infrared
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