scholarly journals Synthesis of 3,6-diaryl-1H-pyrazolo[3,4-b]pyridines via one-pot sequential Suzuki–Miyaura coupling

RSC Advances ◽  
2018 ◽  
Vol 8 (61) ◽  
pp. 34883-34894 ◽  
Author(s):  
Urvashi Urvashi ◽  
Vibha Tandon ◽  
Parthasarathi Das ◽  
S. Kukreti
Keyword(s):  
Efficient Method ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
One Pot ◽  
Cross Coupling Reactions

An efficient method to produce diarylpyrazolo[3,4-b]pyridines derivatives via combination of chemoselective Suzuki–Miyaura cross-coupling reactions has been developed.

A Revised Modular Approach to D8-THC and Derivatives Through Late-Stage Suzuki-Miyaura Cross-Coupling Reactions

2019 ◽  
Author(s):  
Victor Bloemendal ◽  
Floris P. J. T. Rutjes ◽  
Thomas J. Boltje ◽  
Daan Sondag ◽  
Hidde Elferink ◽  
...  
Keyword(s):  
Biological Activity ◽  
Late Stage ◽  
Medicinal Chemistry ◽  
Cross Coupling ◽  
Modular Approach ◽  
Coupling Reactions ◽  
One Pot ◽  
Biologically Relevant ◽  
Cross Coupling Reactions ◽  
Chemistry Research

<p>In this manuscript we describe a modular pathway to synthesize biologically relevant (–)-<i>trans</i>-Δ<sup>8</sup>-THC derivatives, which can be used to modulate the pharmacologically important CB<sub>1</sub> and CB<sub>2</sub> receptors. This pathway involves a one-pot Friedel-Crafts alkylation/cyclization protocol, followed by Suzuki-Miyaura cross-coupling reactions and gives rise to a series of new Δ<sup>8</sup>-THC derivatives. In addition, we demonstrate using extensive NMR evidence that similar halide-substituted Friedel-Crafts alkylation/cyclization products in previous articles were wrongly assigned as the para-isomers, which also has consequence for the assignment of the subsequent cross-coupled products and interpretation of their biological activity. </p> <p>Considering the importance of the availability of THC derivatives in medicinal chemistry research and the fact that previously synthesized compounds were wrongly assigned, we feel this research is describing a straightforward pathway into new cannabinoids.</p>

scholarly journals Synthesis of pentasubstituted 2-aryl pyrroles from boryl and stannyl alkynes via one-pot sequential Ti-catalyzed [2 + 2 + 1] pyrrole synthesis/cross coupling reactions

2020 ◽  
Vol 11 (37) ◽  
pp. 10236-10242
Author(s):  
Yukun Cheng ◽  
Channing K. Klein ◽  
Ian A. Tonks
Keyword(s):  
Small Molecule ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
One Pot ◽  
Cross Coupling Reactions

Multisubstituted pyrroles are commonly found in many bioactive small molecule scaffolds, yet the synthesis of highly-substituted pyrrole cores remains challenging.

Metallic salt-catalyzed direct indium insertion into alkyl iodides and their applications in cross-coupling reactions

2019 ◽  
Vol 6 (3) ◽  
pp. 313-318 ◽  
Author(s):  
Bing-Zhi Chen ◽  
Chuang-Xin Wang ◽  
Zhen-Hua Jing ◽  
Xue-Qiang Chu ◽  
Teck-Peng Loh ◽  
...  
Keyword(s):  
Efficient Method ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Esi Ms ◽  
Cross Coupling Reactions ◽  
Metallic Salt ◽  
Alkyl Iodides

An efficient method for the synthesis of alkyl indium reagents via an indium(iii) or lead(ii) halide-catalyzed direct insertion of indium into alkyl iodides is developed. NMR and ESI-MS analyses indicated the formation of a mixture of an alkyl indium dihalide (RInX2) and a dialkyl indium halide (R2InX).

Pd-Catalyzed one-pot sequential cross-coupling reactions of tetrabromothiophene

2017 ◽  
Vol 15 (48) ◽  
pp. 10289-10298 ◽  
Author(s):  
Kapil Mohan Saini ◽  
Rakesh K. Saunthwal ◽  
Akhilesh K. Verma
Keyword(s):  
Palladium Catalyst ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Arylboronic Acid ◽  
One Pot ◽  
Cross Coupling Reactions ◽  
Sterically Hindered

Unsymmetrical one-pot sequential cross-coupling reactions of sterically hindered tetrabromothiophene with arylboronic acid and an alkyne/alkene to afford selective bi-, tri-, and tetrasubstituted aryl/alkynyl-thiophenes with the aid of a palladium catalyst were described.

Regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2-a]pyridines by Suzuki–Miyaura and Sonogashira cross-coupling reactions

2017 ◽  
Vol 15 (19) ◽  
pp. 4199-4204 ◽  
Author(s):  
P.-O. Delaye ◽  
M. Pénichon ◽  
H. Allouchi ◽  
C. Enguehard-Gueiffier ◽  
A. Gueiffier
Keyword(s):  
Efficient Method ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions

An efficient method for regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2-a]pyridine was developed.

ChemInform Abstract: One-Pot Synthesis of Arylated 1-Methyl-1H-indoles by Suzuki-Miyaura Cross-Coupling Reactions of 2,3-Dibromo-1-methyl-1H-indole and 2,3,6-Tribromo-1-methyl-1H-indole.

ChemInform ◽  
2013 ◽  
Vol 44 (52) ◽  
pp. no-no
Author(s):  
Muhammad Farooq Ibad ◽  
Dhafer Saber Zinad ◽  
Munawar Hussain ◽  
Asad Ali ◽  
Alexander Villinger ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Cross Coupling Reactions
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