scholarly journals An efficient strategy for a controllable droplet merging system for digital analysis

RSC Advances ◽  
2018 ◽  
Vol 8 (60) ◽  
pp. 34343-34349 ◽  
Author(s):  
Yi Qiao ◽  
Jiye Fu ◽  
Fang Yang ◽  
Mengqin Duan ◽  
Mengting Huang ◽  
...  
Keyword(s):  
Success Rate ◽  
Cluster Method ◽  
Digital Analysis ◽  
Efficient Strategy ◽  
Droplet Merging ◽  
The One

We present a one-to-a-cluster pairing strategy to improve the success rate of merging under fluctuation. The one-to-a-cluster method is suitable for digital analysis and droplet MDA was performed in merged droplets successfully.

scholarly journals The effects of framing and ego-involvement on performance on the Wason selection task

Psihologija ◽  
2011 ◽  
Vol 44 (3) ◽  
pp. 261-276 ◽  
Author(s):  
Katarina Jovanovic ◽  
Iris Zezelj
Keyword(s):  
High School Students ◽  
Success Rate ◽  
Early Death ◽  
Selection Task ◽  
School Students ◽  
Wason Selection Task ◽  
Self Image ◽  
Threatening Information ◽  
Ego Involvement ◽  
The One

Man?s deep-rooted tendency to maintain and reinforce a positive self-image makes man inclined to uncritically accept desirable information (the confirmation bias) as well as to criticize and reject undesirable information (the disconfirmation bias). Since disconfirmation strategy leads to a logically correct solution to the four-card Wason selection task, we predicted that ego-involvement manipulation would have a significant effect on the success rate of the task. Specifically, we hypothesized that subjects who were exposed to personally threatening information would try to reject it and thus be more successful on Wason task than those who were exposed to non-threatening information, as established in previously published study by Dawson et al. (2002a). Furthermore, we wanted to examine if manipulating valence framing of the Wason task rule would result in a higher success rate for the group exposed to the threatening and negatively framed rule (that implied their own early death) than the group exposed to the threatening but positively framed rule (that category of people other than the one they belong to live longer). One hundred ninety five high school students from Kragujevac, Serbia participated in the experiment. The results confirmed the expected effect of involvement, while the main effect of framing did not occur. However, there was a marginally significant involvement by framing interaction: unexpectedly, non involved participants were more likely to solve the task correctly when it was positively framed than when in was negatively framed, whilst in the involved group there was no difference in correct responding depending on framing. The findings suggest that the success rate in Wason task can be sensitive to the valence framing of the rule, but only when respondents are not highly personally threatened. Potential methodological interventions in ego-involvement manipulation and content of the rules are discussed.

A gradual desiccation method for improving the efficiency of protein crystallization screening

2012 ◽  
Vol 45 (4) ◽  
pp. 758-765 ◽  
Author(s):  
Qin-Qin Lu ◽  
Xu-Zhuo Xie ◽  
Rui-Qing Chen ◽  
Zi-Qing Wu ◽  
Qing-Di Cheng ◽  
...  
Keyword(s):  
Success Rate ◽  
Protein Crystallization ◽  
Diffusion Method ◽  
Powerful Method ◽  
Vapor Diffusion ◽  
Optimal Amount ◽  
Reservoir Solution ◽  
The One

In vapor diffusion protein crystallization screening, it has been reported that replacing the reservoir solution with desiccant can increase the crystallization success rate. Therefore, the desiccation method is a potentially powerful method in practical protein crystallization screening. However, this method is difficult to apply broadly because the optimal amount of desiccant for a specific screening task is unknown. Utilizing an unsuitable amount of desiccant can result in even worse screening results than would be obtained from the traditional vapor diffusion method. Here, it is shown that by employing a modified strategy, named the gradual desiccation method, the problem can be solved without knowing the optimal amount of desiccant, and the crystallization success rate can be further increased compared with the one-time desiccation method.

Direct Propargylation of ortho-Quinone Methides with Alkynyl Zinc Reagents: An Application to the One-Pot Synthesis of 2,3-Disubstituted Benzofurans

Synlett ◽  
2020 ◽  
Vol 31 (08) ◽  
pp. 818-822
Author(s):  
Hongjun Ren ◽  
Manman Sun ◽  
Jinyu Song ◽  
Lei Wang ◽  
Wenguang Yin ◽  
...  
Keyword(s):  
Transition Metal ◽  
Functional Group ◽  
Quinone Methides ◽  
One Pot ◽  
Metal Free ◽  
Efficient Strategy ◽  
One Pot Synthesis ◽  
Subsequent Cyclization ◽  
The One

A transition-metal-free propargylation of ortho-quinone methides (o-QMs) with alkynyl zinc reagents was achieved. A conjugate alkynylation of an o-QM and subsequent cyclization sequence in the presence of KOt-Bu for the synthesis of 2,3-disubstituted benzofurans in one pot was developed. This efficient strategy exhibits good functional-group compatibility and gives moderate to good yields. The present reaction might serve as an attractive method for the synthesis of polysubstituted benzofurans.

scholarly journals Outcome of antidepressant drug discontinuation with taperingstrips after 1–5 years

2020 ◽  
Vol 10 ◽  
pp. 204512532095460 ◽  
Author(s):  
Peter C. Groot ◽  
Jim van Os
Keyword(s):  
Success Rate ◽  
Antidepressant Drug ◽  
Public Health Problem ◽  
Drug Discontinuation ◽  
Median Length ◽  
Short Term ◽  
Term Outcome ◽  
Antidepressant Use ◽  
To Come ◽  
The One

Background: Stopping antidepressants is often difficult due to withdrawal. Taperingstrips were developed to facilitate antidepressant discontinuation according to the recently described Horowitz-Taylor method, allowing for personalised titration of discontinuation to the intensity of withdrawal. A taperingstrip consists of antidepressant or other medication, packaged in a 28-day roll of small daily pouches, each with the same or slightly lower dose than the one before it. We previously reported that the short-term success rate of antidepressant taperingstrips was 71%. Here, we examine longer-term outcome after 1–5 years. Methods: Patients whose doctor had ordered taperingstrips between January 2015 and December 2019 were sent a questionnaire for participation in anonymised research in January 2020. Of 1012, 483 participated, of whom 408 (85%) had attempted antidepressant tapering. Results: Of the 408 patients included, 192 (47%) had used strips for tapering venlafaxine, 142 (35%) for paroxetine and 74 (18%) for other antidepressants. Median length of antidepressant use was 4 years, and most (61%) had tried to come off without taperingstrips at least once. After 1–5 years, 270 patients (66%) remained off antidepressants after tapering their antidepressant, 6 (2%) had successfully reduced their medication, 87 (21%) had restarted due to (self-reported) relapse, 35 had restarted for another indication (9%), and 10 (3%) reported another outcome. People with more severe experience of withdrawal prior to tapering, and people who had been on antidepressants for a shorter period of time, were more likely to remain off medication after 1–5 years. Conclusion: The previously reported 71% short-term success rate of taperingstrips in the most severely affected group, was matched by a 68% rate after 1–5 years. The evidence-based approach of personal tapering to counter withdrawal, as used for drugs causing withdrawal, for example, benzodiazepines, may represent a simple solution for an important antidepressant-related public health problem, without extra costs.

Effects of Polarization Function on the Spin Contamination and Distribution in β'- Me4P[Pd(dmit)2]2

2019 ◽  
Vol 966 ◽  
pp. 494-500
Author(s):  
Siti Nur Afifi Ahmad ◽  
Shukri Sulaiman ◽  
Lee Sin Ang ◽  
Isao Watanabe
Keyword(s):  
Electron Spin ◽  
Basis Sets ◽  
Cluster Method ◽  
Inhomogeneous Distribution ◽  
Doublet State ◽  
Polarization Function ◽  
Spin Contamination ◽  
The Difference ◽  
The One ◽  
Spin Densities

The effects of polarization function on the spin contamination and distribution in β'-Me4P[Pd(dmit)2]2 were studied using the DFT cluster method. Two basis sets, SV and SVP were considered in the calculations, where B3LYP functional was employed in the doublet state of the one-fragment and dimer clusters. The values of <S2> before annihilation for both SV and SVP basis sets are excellent and very close to the perfect theoretical eigenvalue of 0.75. The values of the spin densities at thiolate and thione calculated using SVP were found to be smaller than the ones using SV. The difference, however, is less than eight percent. In contrast, the difference in the spin density at Pd atoms in both monomers is significantly larger for the SVP, being about 21%. The inclusion of polarization function resulted in the shifting of electron density from the sulfur atoms to the central Pd atoms. The calculated spin densities revealed the inhomogeneous distribution of the electron spin in the dimer that leads to the existence of electron-rich and electron-poor regions.

Investigating Barriers to Knowledge Management Success: A Conceptual Model and a Comparative Case Analysis

2010 ◽  
Vol 09 (04) ◽  
pp. 303-318 ◽  
Author(s):  
Chihab BenMoussa
Keyword(s):  
Knowledge Management ◽  
Success Rate ◽  
Conceptual Model ◽  
Failure Rate ◽  
Case Analysis ◽  
Theoretical Framework ◽  
High Failure Rate ◽  
One Dimensional ◽  
Integrated Studies ◽  
The One

What barriers obstruct the success of knowledge management programs? This paper has integrated studies on the barriers to knowledge management (KM) into a theoretical framework. Based on this framework, five cases documenting failed KM initiatives were analysed. The analysis gives a clear picture about why certain KM projects fail. The high failure rate of KM can be explained by the supply-IT based approach many organisations adopt when it comes to their KM programs. To increase the success rate of KM projects, companies should go beyond the one-dimensional thinking, e.g. technology, and adopt an approach where all the ingredients of KM operate in a synchronised way.

scholarly journals Geometria plana: um estudo sobre o quadrado com alunos do 7º ano do Ensino Fundamental sob a ótica da Teoria de Van Hiele

2017 ◽  
Vol 1 (33) ◽  
pp. 50
Author(s):  
Franklin Fernando Ferreira Pachêco ◽  
Gisele Ferreira Pachêco
Keyword(s):  
Elementary School ◽  
Success Rate ◽  
Qualitative Methodology ◽  
Geometric Figure ◽  
Van Hiele ◽  
Van Hiele Theory ◽  
Physical Form ◽  
Geometric Knowledge ◽  
The One ◽  
Level Of Analysis

<p>The objective of this work is to analyze the level of geometric knowledge of students of the 7th year of Elementary School, through the study of the square, mediated by Van Hiele Theory, which aims to verify the level of geometric knowledge through Of five levels of understanding in a hierarchical way. In addition, it serves as a contribution for the teacher to organize his classes and to identify the existing gaps about the geometric knowledge that the students possess, through a content, especially the one of the flat geometry. We approach a qualitative methodology with a diagnostic character. Participated in this work 26 students of the 7th grade of Elementary School of a public school, located in the municipality of São Vicente Férrer-PE. In this paper, we use two questions from a test. The first question presented a set of polygonal and non-polygonal figures, aiming at the students to identify the squares, from their physical form. The second question had as objective to verify if the students quoted the properties of the squares, exposing a greater knowledge of this geometric figure. According to the protocols presented by the students, the first question - which referred to the identification of the square from its physical form - presented a high success rate. The second question, which related to the properties of the square, presented a low success rate. Before our analysis, we can verify that, in the identification of the squares by means of their physical form, there is no evidence of difficulties by the students, but there is a certain fragility to cite their properties. In general, therefore, we analyze the protocols of the students, according to the levels of understanding of Van Hiele Theory, noting that these correspond to the level of analysis, because they are progressing in the perception of geometric knowledge, especially in the figure of the square</p>

scholarly journals Clinical Effects of Form-Based Management of Forceps Delivery under Intelligent Medical Model

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Siming Xin ◽  
Zhizhong Wang ◽  
Hua Lai ◽  
Lingzhi Liu ◽  
Ting Shen ◽  
...  
Keyword(s):  
Success Rate ◽  
Medical Model ◽  
Adverse Outcomes ◽  
Neonatal Outcomes ◽  
Control Group ◽  
Clinical Effects ◽  
Forceps Delivery ◽  
Delivery Methods ◽  
Maternal And Neonatal Outcomes ◽  
The One

Background. Forceps delivery is one of the most important measures to facilitate vaginal delivery. It can reduce the rate of first cesarean delivery. Frustratingly, adverse maternal and neonatal outcomes associated with forceps delivery have been frequently reported in recent years. There are two major reasons: one is that the abilities of doctors and midwives in forceps delivery vary from hospital to hospital and the other one is lack of regulations in the management of forceps delivery. In order to improve the success rate of forceps delivery and reduce the incidence of maternal and neonatal complications, we applied form-based management to forceps delivery under an intelligent medical model. The aim of this work is to explore the clinical effects of form-based management of forceps delivery. Methods. Patients with forceps delivery in Maternal and Child Health Hospital Affiliated to Nanchang University were divided into two groups: form-based patients from January 1, 2019, to December 31, 2020, were selected as the study group, while traditional protocol patients from January 1, 2017, to December 31, 2018, were chosen as the control group. Then, we compared the maternal and neonatal outcomes of these two groups. Results. There were significant differences in the maternal and neonatal adverse outcomes such as rate of postpartum hemorrhage, degree of perineal laceration, and incidence of neonatal facial skin abrasions between the two groups, whereas differences in the incidence of asphyxia and intracranial hemorrhage were not significant. Conclusions. Form-based management could help us assess the security of forceps delivery comprehensively, as it could not only improve the success rate of the one-time forceps traction scheme but also reduce the incidence of maternal and neonatal adverse outcomes effectively.

scholarly journals Combined Phacoendoscopic Cyclophotocoagulation versus Combined Phacotrabeculectomy in the Management of Coexisting Cataract and Glaucoma: A Comparative Study

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Charles Sing Lok Lau ◽  
Jeffrey Chi Wang Chan ◽  
Sophia Fei So ◽  
Orlando Chia Chieh Chan ◽  
Kenneth Kai Wang Li
Keyword(s):  
Success Rate ◽  
Surgical Procedures ◽  
Surgical Intervention ◽  
Operation Time ◽  
Macula Edema ◽  
One Year ◽  
The One ◽  
Significant Cataract ◽  
Cystoid Macula Edema

Purpose. To compare the surgical outcome of combined phacoemulsification and endoscopic cyclophotocoagulation (phacoECP) versus combined phacoemulsification and mitomycin C-augmented trabeculectomy (phacoTbx) in patients with coexisting glaucoma and visually significant cataract. Methods. A retrospective review of 89 eyes of 89 patients who received phacoECP (N=49) and phacoTbx (N=40) was carried out at a tertiary eye center in Hong Kong. The minimum follow-up period was 6 months. Criterion of success was reduction of IOP at least 30% or absolute IOP of 15 mmHg or below without (complete success) or with (qualified success) antiglaucomatous medication. Results. PhacoTbx had more reduction of antiglaucomatous medication (4 vs 1, P<0.001). At postoperative year one, there was more IOP reduction for phacoTbx than phacoECP (8 mmHg vs 3 mmHg, P=0.012). The one-year complete success rate was also higher for phacoTbx (46.2% vs 8.2%, P<0.001), while qualified success was comparable between the 2 groups (74.4% vs 73.5%, P=0.925). Operation time was shorter for phacoECP (37 vs 73 minutes, P<0.001). The number of postoperative follow-up visits was less (6 vs 11.5, P<0.001) for phacoECP. Additional surgical procedures were more common in phacoTbx (55% vs 0%, P<0.001). There was no postoperative cystoid macula edema, hypotony, or endophthalmitis reported in both groups. Conclusions. PhacoECP is significantly less effective than phacoTbx in reduction of both IOP and number of antiglaucomatous medications for patients with medically uncontrolled glaucoma and cataract. Its complete success rate is also significantly lower than that of phacoTbx. With its comparable qualified success, shorter operation time, less number of postoperative visits, and secondary surgical intervention, phacoECP may still have a role in very selected cases.

scholarly journals Nonsurgical Management of Apical Root Perforation Using Mineral Trioxide Aggregate

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Omar Alzahrani ◽  
Faisal Alghamdi
Keyword(s):  
Success Rate ◽  
Mineral Trioxide Aggregate ◽  
Apical Part ◽  
Success Rates ◽  
Nonsurgical Management ◽  
Gutta Percha ◽  
Tissue Healing ◽  
Root Canal Retreatment ◽  
One Year ◽  
The One

This study illustrates a conservative approach to nonsurgical management of apical root perforation in maxillary first molars. A patient was referred for retreatment of a maxillary left first molar. Her chief complaint was dull pain while biting in her maxillary left first molar. Periapical radiography showed radiolucency related to the mesiobuccal root and overextended gutta-percha through a perforation in the apical part of the distobuccal root. A CBCT scan was acquired and revealed the location and size of the apical perforation. The clinical examination showed that the tooth has been endodontically treated and the canals were filled, tender to percussion and palpation. Thus, the nonsurgical root canal retreatment was done and the perforation site was repaired by using mineral trioxide aggregate (MTA). At the one-year follow-up, after the management of apical root perforation, we observed periapical tissue healing and no pain due to percussion and palpation, without any clinical/radiological signs or symptoms. The prognosis of this case has a higher success rate with the development of new materials such as MTA. The MTA not only can seal the site of the perforation but also has the ability to induce calcification. Many factors can contribute to the success rate of perforated cases, including time, size, and location of the perforation. With the use of this material and good tools like a microscope, there are those with having higher chances of repair and eventually higher success rates.

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