scholarly journals Recent development of boronic acid-based fluorescent sensors

RSC Advances ◽  
2018 ◽  
Vol 8 (51) ◽  
pp. 29400-29427 ◽  
Author(s):  
Guiqian Fang ◽  
Hao Wang ◽  
Zhancun Bian ◽  
Jie Sun ◽  
Aiqin Liu ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Boronic Acid ◽  
Lewis Acids ◽  
Boronic Acids ◽  
Fluorescent Sensors ◽  
Cyclic Esters

As Lewis acids, boronic acids can bind with 1,2- or 1,3-diols in aqueous solution reversibly and covalently to form five or six cyclic esters, thus resulting in significant fluorescence changes.

Borinic Acids: A Neglected Class of Organoboron Compounds for Recognition of Diols in Aqueous Solution

2011 ◽  
Vol 64 (11) ◽  
pp. 1466 ◽  
Author(s):  
Michael G. Chudzinski ◽  
Yuechuan Chi ◽  
Mark S. Taylor
Keyword(s):  
Aqueous Solution ◽  
Boronic Acid ◽  
Covalent Binding ◽  
Boronic Acids ◽  
Association Constants ◽  
Electronic Tuning ◽  
Displacement Assay ◽  
High Level ◽  
Related Compounds ◽  
Borinic Acid

Association constants between diphenylborinic acid and representative analytes capable of reversible two-point covalent binding (diols, catechols, and hydroxy acids) were determined using an indicator-displacement assay. Unlike boronic acids, which have been studied in great detail as receptors for diols and related compounds, borinic acids have effectively been ignored as candidates for such applications. The results of this study indicate that diphenylborinic acid displays high affinity for certain analytes of this type in aqueous solution. Of particular interest are differences between the selectivity of the borinic acid and that of a boronic acid of similar pKa towards the series of analytes studied: the borinic acid displays an unusually high level of discrimination for catechols over carbohydrates. The distinct selectivity observed, and the unique opportunities for steric and electronic tuning of diarylborinic acids, suggest that these compounds hold significant potential for applications in aqueous-phase molecular recognition.

scholarly journals Highly sensitive detection of nitrobenzene by a series of fluorescent 2D zinc(ii) metal–organic frameworks with a flexible triangular ligand

RSC Advances ◽  
2021 ◽  
Vol 11 (39) ◽  
pp. 23975-23984
Author(s):  
Xue Yang ◽  
Yixia Ren ◽  
Hongmei Chai ◽  
Xiufang Hou ◽  
Zhixiang Wang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Metal Organic Frameworks ◽  
High Sensitivity ◽  
Fluorescent Sensors ◽  
Sensitive Detection ◽  
Donor Ligands ◽  
Highly Sensitive ◽  
Metal Organic ◽  
Highly Sensitive Detection

Four fluorescent 2D Zn-MOFs based on a flexible triangular ligand and linear N-donor ligands are hydrothermally prepared and used to detect nitrobenzene in aqueous solution with high sensitivity, demonstrating their potential as fluorescent sensors.

scholarly journals Recent Advances in Transition-Metal-Free (4+3)-Annulations

Synthesis ◽  
2021 ◽  
Author(s):  
Heather Lam ◽  
Mark Lautens ◽  
Xavier Abel-Snape ◽  
Martin F. Köllen
Keyword(s):  
Transition Metal ◽  
Boronic Acid ◽  
Lewis Acids ◽  
Acid Catalysis ◽  
Heterocyclic Carbenes ◽  
Bronsted Acids ◽  
Metal Free ◽  
Previous Review ◽  
Dual Activation ◽  
Metal Catalyzed

Abstract(4+3)-Annulations are incredibly versatile reactions which combine a 4-atom synthon and a 3-atom synthon to form both 7-membered carbocycles as well as heterocycles. We have previously reviewed transition-metal-catalyzed (4+3)-annulations. In this review, we will cover examples involving bases, NHCs, phosphines, Lewis and Brønsted acids as well as some rare examples of boronic acid catalysis and photocatalysis. In analogy to our previous review, we exclude annulations involving cyclic dienes like furan, pyrrole, cyclohexadiene or cyclopentadiene, as Chiu, Harmata, Fernándes and others have recently published reviews encompassing such substrates. We will however discuss the recent additions (2010–2020) to the literature on (4+3)-annulations involving other types of 4-atom-synthons.1 Introduction2 Bases3 Annulations Using N-Heterocyclic Carbenes3.1 N-Heterocyclic Carbenes (NHCs)3.2 N-Heterocyclic Carbenes and Base Dual-Activation4 Phosphines5 Acids5.1 Lewis Acids5.2 Brønsted Acids6 Boronic Acid Catalysis and Photocatalysis7 Conclusion

scholarly journals A Theoretical Model to Study the Interaction Between Boronic Acids and Insulin

2020 ◽  
Author(s):  
Durgesh Kumar ◽  
Kamlesh Kumari ◽  
PRASHANT SINGH
Keyword(s):  
Amino Acids ◽  
Theoretical Model ◽  
Boronic Acid ◽  
Significant Interaction ◽  
Biological Activities ◽  
Boronic Acids ◽  
Biological Molecules ◽  
Computational Tools ◽  
Medical Expertise ◽  
Stabilizing Agents

Boronic acids are widely used in various applications in view of their ability to recognize and bind at specific sites of the biological molecules to mimic several processes. Therefore, this has attracted the researchers, academician and medical expertise to explore them. In the present work, the authors have designed a theoretical approach to study the interaction of boronic acid with insulin using computational tools. A library of boronic acids (114 compounds) are designed, optimized and interacted with insulin using computational tools i.e. iGEMDOCK. Further, their different biological activities and toxicity are determined. Results indicates the promising potential of the boronic acids on interaction with the insulin. Amongst, 114 molecules of boronic acids, 3-Benzyloxyphenylboronic acid (71) showed the best interaction with amino-acids of insulin and significant interaction was shown with the Glu21 and His5 residues. Further, these results were compared with the stabilizing agents and found to be more potent.

Turn-off/on fluorescent sensors for Cu2+ and ATP in aqueous solution based on a tetraphenylethylene derivative

2019 ◽  
Vol 7 (9) ◽  
pp. 2640-2645 ◽  
Author(s):  
Lai-Yao Geng ◽  
Yang Zhao ◽  
Edward Kamya ◽  
Jin-Tang Guo ◽  
Bin Sun ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Adenosine Triphosphate ◽  
Rapid Detection ◽  
Fluorescent Sensors ◽  
Cupric Ion

Two novel fluorescent sensors based on a tetraphenylethylene derivative (TPE-COOH) were designed and prepared for the rapid detection of cupric ion and adenosine triphosphate (ATP) in 100% aqueous solution.

(DPEPhos)Ni(mesityl)Br: An Air-Stable Pre-Catalyst for Challenging Suzuki–Miyaura Cross-Couplings Leading to Unsymmetrical Biheteroaryls

Synlett ◽  
2018 ◽  
Vol 29 (06) ◽  
pp. 799-804 ◽  
Author(s):  
Mark Stradiotto ◽  
Ryan Sawatzky
Keyword(s):  
Boronic Acid ◽  
Cross Coupling ◽  
Boronic Acids ◽  
Mild Conditions

The successful application of (DPEPhos)Ni(mesityl)Br (C1) as a pre-catalyst in the Suzuki–Miyaura cross-coupling of heteroaryl chlorides or bromides and heteroaryl boronic acids is reported. The use of C1 in this context allows for such reactions to be conducted under mild conditions (2 mol% Ni, 25 °C), including cross-couplings leading to unsymmetrical biheteroaryls. Successful transformations of this type involving problematic pyridinyl boronic acid substrates (10 mol% Ni, 60 °C) are also described.

Detailed Reaction Mechanisms of 4‐Pyridylboronic Acid and (N‐Methyl)‐4‐Pyridinium Boronic Acid with D‐Sorbitol in Aqueous Solution

2019 ◽  
Vol 4 (17) ◽  
pp. 4944-4951
Author(s):  
Daisuke Kusuyama ◽  
Yuta Samukawa ◽  
Tomoaki Sugaya ◽  
Satoshi Iwatsuki ◽  
Masahiko Inamo ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Reaction Mechanisms ◽  
Boronic Acid

scholarly journals Carbonylative Suzuki–Miyaura couplings of sterically hindered aryl halides: synthesis of 2-aroylbenzoate derivatives

2020 ◽  
Vol 18 (9) ◽  
pp. 1754-1759 ◽  
Author(s):  
Aya Ismael ◽  
Troels Skrydstrup ◽  
Annette Bayer
Keyword(s):  
Boronic Acid ◽  
Boronic Acids ◽  
Aryl Halides ◽  
Aryl Bromides ◽  
Sterically Hindered

A new protocol for carbonylative coupling of sterically hindered aryl bromides with boronic acids featuring slow addition of the boronic acid as a strategy to suppress unwanted non-carbonylative couplings for sterically hindered aryl bromides.

Fluorescent sensors based on [12]aneN3-modified BODIPY: Discrimination of different biological thiols in aqueous solution and living cells

2016 ◽  
Vol 24 (7) ◽  
pp. 1550-1559 ◽  
Author(s):  
Yong-Guang Gao ◽  
Ying Zhang ◽  
You-Di Shi ◽  
Hu-Jun Hao ◽  
Bing Gong ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Living Cells ◽  
Fluorescent Sensors
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