Folate-targeted selenium nanoparticles deliver therapeutic siRNA to improve hepatocellular carcinoma therapy

Yu Xia; Mingqi Zhao; Yi Chen; Liang Hua; Tiantian Xu; Changbing Wang; Yinghua Li; Bing Zhu

doi:10.1039/c8ra04204g

Folate-targeted selenium nanoparticles deliver therapeutic siRNA to improve hepatocellular carcinoma therapy

RSC Advances ◽

10.1039/c8ra04204g ◽

2018 ◽

Vol 8 (46) ◽

pp. 25932-25940 ◽

Cited By ~ 10

Author(s):

Yu Xia ◽

Mingqi Zhao ◽

Yi Chen ◽

Liang Hua ◽

Tiantian Xu ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Folic Acid ◽

Selenium Nanoparticles ◽

Effective Strategy ◽

Se Nanoparticles

We provide an effective strategy for the design of tumor-targeted nanodrugs against hepatocellular carcinoma by functionalising Se nanoparticles with polyethylenimine linked with folic acid and siRNA.

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Dietary modulations of folic acid affect the development of diethylnitrosamine induced hepatocellular carcinoma in a rat model

Journal of Molecular Histology ◽

10.1007/s10735-020-09955-9 ◽

2021 ◽

Author(s):

Renuka Sharma ◽

Taqveema Ali ◽

Ishwar Negi ◽

Ashim Das ◽

Ajay Duseja ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Folic Acid ◽

Rat Model

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ALK Folic Acid Transport and Integrin Signal Induced-Angiogenesis Network in Human Hepatocellular Carcinoma (HCC) by Systems-Theoretical Analysis

Molecular Biology ◽

10.4172/2168-9547.1000102 ◽

2012 ◽

Vol 01 (01) ◽

Author(s):

Lin Wang

Keyword(s):

Hepatocellular Carcinoma ◽

Folic Acid ◽

Theoretical Analysis ◽

Human Hepatocellular Carcinoma ◽

Acid Transport

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Encapsulation of SHT-DNA, siRNA and Polypeptide -17 inside Hybrid Polymeric Nano-Protein Folic Acid (HPNP-FA) Carrier as Targeted TGFb Inhibitor for Hepatocellular Carcinoma

Journal of Hepatology ◽

10.1016/s0168-8278(16)01043-6 ◽

2016 ◽

Vol 64 (2) ◽

pp. S573 ◽

Cited By ~ 1

Author(s):

N.A.N. Hanafy ◽

A. Quarta ◽

R. Di Corato ◽

L. Dini ◽

C. Nobile ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Folic Acid

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Evaluation of selenium nanoparticles and doxorubicin effect against hepatocellular carcinoma rat model cytogenetic toxicity and DNA damage

Toxicology Reports ◽

10.1016/j.toxrep.2018.07.003 ◽

2018 ◽

Vol 5 ◽

pp. 771-776 ◽

Cited By ~ 10

Author(s):

Omaima M. Abd El-Moneim ◽

Abeer H. Abd El-Rahim ◽

Naglaa A. Hafiz

Keyword(s):

Hepatocellular Carcinoma ◽

Dna Damage ◽

Rat Model ◽

Selenium Nanoparticles

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Combination Therapy with MAPK-Pathway-Specific Inhibitor and Folic-Acid-Receptor-Targeted Selenium Nanoparticles Induces Synergistic Antiproliferative Response in BRAF Mutant Cancer Cells

ACS Biomaterials Science & Engineering ◽

10.1021/acsbiomaterials.9b00112 ◽

2019 ◽

Vol 5 (5) ◽

pp. 2222-2234 ◽

Cited By ~ 2

Author(s):

Anil Parsram Bidkar ◽

Pallab Sanpui ◽

Siddhartha Sankar Ghosh

Keyword(s):

Folic Acid ◽

Combination Therapy ◽

Cancer Cells ◽

Mapk Pathway ◽

Specific Inhibitor ◽

Selenium Nanoparticles ◽

Acid Receptor ◽

Folic Acid Receptor ◽

Braf Mutant

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695 OMACETAXINE AS A POTENTIAL EFFECTIVE STRATEGY FOR HEPATOCELLULAR CARCINOMA

Gastroenterology ◽

10.1016/s0016-5085(20)33883-x ◽

2020 ◽

Vol 158 (6) ◽

pp. S-1288

Author(s):

Ling Li ◽

Gilad Halpert ◽

Haijie Hu ◽

Peter Dimitrion ◽

Matthew J. Weiss ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Effective Strategy

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Bevacizumab and folic acid dual-targeted gadolinium-carbon dots for fluorescence/magnetic resonance imaging of hepatocellular carcinoma

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2020.102288 ◽

2021 ◽

Vol 61 ◽

pp. 102288

Author(s):

Fatemeh Maghsoudinia ◽

Mohamad Bagher Tavakoli ◽

Roghayeh Kamran Samani ◽

Hasan Motaghi ◽

Seyed Hossein Hejazi ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Hepatocellular Carcinoma ◽

Folic Acid ◽

Magnetic Resonance ◽

Carbon Dots ◽

Resonance Imaging

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Intratumoral Neoadjuvant Immunotherapy Using IL-12 and Dendritic Cells Is an Effective Strategy To Control Recurrence of Murine Hepatocellular Carcinoma in Immunosuppressed Mice

The Journal of Immunology ◽

10.4049/jimmunol.0900187 ◽

2010 ◽

Vol 185 (1) ◽

pp. 698-708 ◽

Cited By ~ 17

Author(s):

Hiroto Kayashima ◽

Takeo Toshima ◽

Shinji Okano ◽

Akinobu Taketomi ◽

Noboru Harada ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Dendritic Cells ◽

Effective Strategy ◽

Neoadjuvant Immunotherapy ◽

Immunosuppressed Mice

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PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction

International Journal of Nanomedicine ◽

10.2147/ijn.s30940 ◽

2012 ◽

pp. 3939 ◽

Cited By ~ 9

Author(s):

Tianfeng Chen ◽

Zheng ◽

Li ◽

Zhang ◽

Zheng ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Drug Resistance ◽

Hepg2 Cells ◽

Selenium Nanoparticles ◽

Mitochondria Dysfunction

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Novel roles of folic acid as redox regulator: Modulation of reactive oxygen species sinker protein expression and maintenance of mitochondrial redox homeostasis on hepatocellular carcinoma

Tumor Biology ◽

10.1177/1010428317702649 ◽

2017 ◽

Vol 39 (6) ◽

pp. 101042831770264 ◽

Cited By ~ 7

Author(s):

Kun-Goung Lai ◽

Chi-Fen Chen ◽

Chun-Te Ho ◽

Jun-Jen Liu ◽

Tsan-Zon Liu ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Reactive Oxygen Species ◽

Folic Acid ◽

Protein Expression ◽

Redox Homeostasis ◽

Reactive Oxygen ◽

Oxygen Species

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