scholarly journals Biocompatible surface modification of nano-scale zeolitic imidazolate frameworks for enhanced drug delivery

RSC Advances ◽  
2018 ◽  
Vol 8 (42) ◽  
pp. 23623-23628 ◽  
Author(s):  
Yuqing Li ◽  
Yongtai Zheng ◽  
Xinyi Lai ◽  
Yuehuan Chu ◽  
Yongming Chen
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Hyaluronic Acid ◽  
Cancer Treatment ◽  
Zeolitic Imidazolate Frameworks ◽  
Nano Scale ◽  
Anti Cancer

In this study, we present a general approach for harnessing the surface of ZIF-8 with hyaluronic acid (HA) for enhanced anti-cancer treatment by efficient curcumin (CCM) delivery.

scholarly journals Novel Surface Modification of ZnO QDs for Paclitaxel-Targeted Drug Delivery for Lung Cancer Treatment

Dose-Response ◽  
2020 ◽  
Vol 18 (2) ◽  
pp. 155932582092673
Author(s):  
Chuan Xie ◽  
Yan Zhan ◽  
Peng Wang ◽  
Bo Zhang ◽  
Yukun Zhang
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
High Efficiency ◽  
A549 Cells ◽  
Cytotoxicity Studies

Adipic dihydrazide and heparin were attached to ZnO quantum dots surface, and the ZnO-adipic dihydrazide-heparin nanocomplex was used as a drug delivery system to deliver paclitaxel for chemotherapy. The surface modification and the loading of paclitaxel were confirmed by Fourier transform infrared spectrum, featured by characteristic peaks from functional groups of adipic dihydrazide, heparin, and paclitaxel. The impacts of pH on the drug release were investigated, and the cytotoxicity studies were conducted with A549 cells. The pharmacokinetic study was conducted with male Wistar rats. Both in vitro and in vivo study indicated that ZnO-adipic dihydrazide-heparin-paclitaxel nanocomplex could deliver paclitaxel in a more controllable way, and it has the potential to be a high-efficiency drug delivery system for cancer treatment.

Research Findings

2006 ◽  
Vol 10 (22) ◽  
pp. 1300-1305
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Nobel Prize Winner ◽  
Molecular Probe ◽  
Cancer Drug ◽  
Drug Candidate ◽  
Hiv Test ◽  
Anti Cancer ◽  
Research Findings

S*Bio Develops Singapore's First Clinical Anti-Cancer Drug Candidate. Scientists make Diagnoses Easier Through New Molecular Probe. Nobel Prize Winner Hopes China to Contribute More to Biotech. India Fears about Faulty HIV Test Kits that will Spread Disease. Injectable Hyaluronic Acid–Tyramine Hydrogels Formed by Enzyme for Drug Delivery and Tissue Engineering.

scholarly journals Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 152
Author(s):  
Eleen Dayana Mohamed Isa ◽  
Haslina Ahmad ◽  
Mohd Basyaruddin Abdul Rahman ◽  
Martin R. Gill
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Silica Nanoparticles ◽  
High Stability ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
High Surface Area ◽  
Surgical Removal

Cancer treatment and therapy have made significant leaps and bounds in these past decades. However, there are still cases where surgical removal is impossible, metastases are challenging, and chemotherapy and radiotherapy pose severe side effects. Therefore, a need to find more effective and specific treatments still exists. One way is through the utilization of drug delivery agents (DDA) based on nanomaterials. In 2001, mesoporous silica nanoparticles (MSNs) were first used as DDA and have gained considerable attention in this field. The popularity of MSNs is due to their unique properties such as tunable particle and pore size, high surface area and pore volume, easy functionalization and surface modification, high stability and their capability to efficiently entrap cargo molecules. This review describes the latest advancement of MSNs as DDA for cancer treatment. We focus on the fabrication of MSNs, the challenges in DDA development and how MSNs address the problems through the development of smart DDA using MSNs. Besides that, MSNs have also been applied as a multifunctional DDA where they can serve in both the diagnostic and treatment of cancer. Overall, we argue MSNs provide a bright future for both the diagnosis and treatment of cancer.

scholarly journals Biomedical Applications of Hyaluronic Acid-Based Nanomaterials in Hyperthermic Cancer Therapy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 306 ◽  
Author(s):  
Subin Kim ◽  
Myeong ju Moon ◽  
Suchithra Poilil Surendran ◽  
Yong Yeon Jeong
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Biomedical Applications ◽  
Treatment Approach ◽  
Critical Role ◽  
Sulfated Polysaccharide

Hyaluronic acid (HA) is a non-sulfated polysaccharide polymer with the properties of biodegradability, biocompatibility, and non-toxicity. Additionally, HA specifically binds to certain receptors that are over-expressed in cancer cells. To maximize the effect of drug delivery and cancer treatment, diverse types of nanomaterials have been developed. HA-based nanomaterials, including micelles, polymersomes, hydrogels, and nanoparticles, play a critical role in efficient drug delivery and cancer treatment. Hyperthermic cancer treatment using HA-based nanomaterials has attracted attention as an efficient cancer treatment approach. In this paper, the biomedical applications of HA-based nanomaterials in hyperthermic cancer treatment and combined therapies are summarized. HA-based nanomaterials may become a representative platform in hyperthermic cancer treatment.

Cholesteryl hyaluronic acid-coated, reduced graphene oxide nanosheets for anti-cancer drug delivery

Biomaterials ◽  
2013 ◽  
Vol 34 (37) ◽  
pp. 9638-9647 ◽  
Author(s):  
Wenjun Miao ◽  
Gayong Shim ◽  
Choong Mo Kang ◽  
Soondong Lee ◽  
Yearn Seong Choe ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Hyaluronic Acid ◽  
Reduced Graphene Oxide ◽  
Cancer Drug ◽  
Graphene Oxide Nanosheets ◽  
Reduced Graphene ◽  
Anti Cancer ◽  
Cancer Drug Delivery

Curcumin loaded mesoporous silica: an effective drug delivery system for cancer treatment

2016 ◽  
Vol 4 (3) ◽  
pp. 448-459 ◽  
Author(s):  
Rajesh Kotcherlakota ◽  
Ayan Kumar Barui ◽  
Sanjiv Prashar ◽  
Mariano Fajardo ◽  
David Briones ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Normal Cells ◽  
Silica Material ◽  
Anti Cancer

Mesoporous silica material based drug delivery systems (DDSs) containing curcumin show biocompatibility in normal cells and an effective anti-cancer effect in cancer cells.

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