scholarly journals Enhancing the anti-ovarian cancer activity of quercetin using a self-assembling micelle and thermosensitive hydrogel drug delivery system

RSC Advances ◽  
2018 ◽  
Vol 8 (38) ◽  
pp. 21229-21242 ◽  
Author(s):  
Guangya Xu ◽  
Bin Li ◽  
Ting Wang ◽  
Jun Wan ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Thermosensitive Hydrogel ◽  
Injectable Hydrogel ◽  
Self Assembling ◽  
System P ◽  
Hydrogel Composites ◽  
Cancer Activity ◽  
Hydrogel System

In this study, a quercetin-loaded thermosensitive injectable hydrogel system (Qu-M–hydrogel composites) was constructed based on nanotechnology.

scholarly journals Correction: Enhancing the anti-ovarian cancer activity of quercetin using a self-assembling micelle and thermosensitive hydrogel drug delivery system

RSC Advances ◽  
2019 ◽  
Vol 9 (57) ◽  
pp. 33193-33194
Author(s):  
Guangya Xu ◽  
Bin Li ◽  
Ting Wang ◽  
Jun Wan ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Thermosensitive Hydrogel ◽  
Self Assembling ◽  
System P ◽  
Cancer Activity

Correction for ‘Enhancing the anti-ovarian cancer activity of quercetin using a self-assembling micelle and thermosensitive hydrogel drug delivery system’ by Guangya Xu et al., RSC Adv., 2018, 8, 21229–21242.

A bio-inspired fluorescent nano-injectable hydrogel as a synergistic drug delivery system

2021 ◽  
Vol 45 (6) ◽  
pp. 3079-3087
Author(s):  
Yue Xu ◽  
Mingming Yang ◽  
Qiyue Ma ◽  
Xiang Di ◽  
Guolin Wu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Fluorescence Properties ◽  
Injectable Hydrogel ◽  
Sequential Release ◽  
System P

A nano-injectable hydrogel with fluorescence properties and controlled sequential release of dual drugs.

Improving the Anti-Ovarian Cancer Activity of Docetaxel by Self-Assemble Micelles and Thermosensitive Hydrogel Drug Delivery System

2020 ◽  
Vol 16 (1) ◽  
pp. 40-53
Author(s):  
Guangya Xu ◽  
Changhui Zhu ◽  
Bin Li ◽  
Ting Wang ◽  
Jun Wan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Water Solubility ◽  
Drug Loading ◽  
Apoptosis Induction ◽  
Sustained Drug Release ◽  
Antitumor Effects ◽  
Thermosensitive Hydrogel ◽  
Hydrogel Composites ◽  
Cancer Activity

In recent decades, a large number of research studies have been conducted to improve the treatment strategy against epithelial ovarian cancer, but women in advanced stage still have poor outcomes. The development of advanced treatments must be continued to overcome the limitation. Docetaxel, a semi-synthetic product derived from the Pacific Taxus extract, has been studied for many years for its potent anticancer applications. Aiming to solve the problems of its highly lipophilicity, insolubility and adverse side effects, nanocarriers were applied. Relying on the integration of nanoparticles which had optimized sizes, shapes, and surface properties, the effect of docetaxel was enhanced. In this study, we designed a novel drug loaded gel-forming nanoparticle system (Doc-NMs-hydrogel composites), which acted as a sustained drug depot for docetaxel. Docetaxel was encapsulated into MPEG-PCL and then into blank thermosensitive hydrogel Pluronic F-127. Characterization showed that the prepared Doc-NMs had high drug loading (7%), minor particle size (37 nm), relatively good water solubility. Moreover, the cytotoxicity, apoptosis induction and the antitumor effects of Doc-NMs-hydrogel composites on mice abdominal SKOV-3 ovarian cancer model were investigated in vivo. Compared with other groups, at the same dosage, Doc-NMs-hydrogel composites show better apoptosis induction and cell growth inhibition. In conclusion, the prepared Doc-NMs-hydrogel composites enhanced anti-tumor activity by increasing local docetaxel concentration, maintaining stable and sustained drug release, prolonging drug retention time in tumors, and reducing toxicity to normal tissues. Doc-NMs-hydrogel composites might have great potential clinical application in anti-ovarian cancer activity.

Modified PLGA–PEG–PLGA thermosensitive hydrogels with suitable thermosensitivity and properties for use in a drug delivery system

2017 ◽  
Vol 5 (8) ◽  
pp. 1551-1565 ◽  
Author(s):  
Puxiu Wang ◽  
Wei Chu ◽  
Xuezhi Zhuo ◽  
Yu Zhang ◽  
Jingxin Gou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Triblock Copolymer ◽  
Thermosensitive Hydrogel ◽  
System P ◽  
Thermosensitive Hydrogels

PLGA–PEG–PLGA (PPP) triblock copolymer is the most widely studied thermosensitive hydrogel owing to its non-toxic, biocompatible, biodegradable, and thermosensitive properties.

scholarly journals Development and in vitro Evaluation of Gastro-protective Aceclofenac-loaded Self-emulsifying Drug Delivery System

2020 ◽  
Vol Volume 15 ◽  
pp. 5217-5226 ◽  
Author(s):  
Chen Jianxian ◽  
Kalsoom Saleem ◽  
Muhammad Ijaz ◽  
Masood Ur-Rehman ◽  
Ghulam Murtaza ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Evaluation ◽  
System P

Targeted killing of metastatic cells using a platelet-inspired drug delivery system

RSC Advances ◽  
2015 ◽  
Vol 5 (57) ◽  
pp. 46218-46228 ◽  
Author(s):  
Victor Pan ◽  
Preethi N. Siva ◽  
Christa L. Modery-Pawlowski ◽  
Ujjal Didar Singh Sekhon ◽  
Anirban Sen Gupta
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Drug Delivery System ◽  
Targeted Drug Delivery ◽  
Metastatic Tumor ◽  
Targeted Killing ◽  
Metastatic Cells ◽  
System P ◽  
Delivery Vehicles ◽  
Targeted Drug

Pro-metastatic tumor cells in circulation interact with active platelets that mediate various mechanisms of hematologic metastasis. Elucidating and utilizing these interactions on delivery vehicles can provide unique ways of metastasis-targeted drug delivery.

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