scholarly journals A non-invasive approach to explore the discriminatory potential of the urinary volatilome of invasive ductal carcinoma of the breast

RSC Advances ◽  
2018 ◽  
Vol 8 (44) ◽  
pp. 25040-25050 ◽  
Author(s):  
Khushman Taunk ◽  
Ravindra Taware ◽  
Tushar H. More ◽  
Priscilla Porto-Figueira ◽  
Jorge A. M. Pereira ◽  
...  

A non-invasive urinary volatilomics approach for exploring the IDC type breast cancer.

Author(s):  
Ida Pucci-Minafra ◽  
Gianluca Di Cara ◽  
Rosa Musso ◽  
Patrizia Cancemi ◽  
Nadia Ninfa Albanese ◽  
...  

The present investigation has been conducted on one hundred tissue fragments of breast cancer, collected and immediately cryopreserved following the surgical resection. The fragments were selected from patients with invasive ductal carcinoma of the breast, the most common and potentially aggressive type of mammary cancer, with the objective to increase the knowledge of breast cancer molecular markers, useful for diagnostic and prognostic categorization of patients, in assessing post-surgical therapeutic regimes. The proteomic screening, by 2D-IPG and mass spectrometry, allowed us to identify two main classes of protein clusters: proteins expressed ubiquitously at high levels in all patients, and proteins expressed sporadically among the same patients. Within the group of ubiquitous proteins, glycolytic enzymes and proteins with anti-apoptotic activity were predominant. Among the sporadic ones, proteins involved in cell motility, molecular chaperones and proteins involved in the detoxification appeared prevalent. The data of the present study indicates that the primary tumor growth is generally supported by two concurrent pathways: the inhibition of apoptosis and the stimulation of cellular proliferation. The second phase of the evolution of the tumor can be prematurely scheduled by the occasional presence of proteins involved in cell motility and in the defenses of the oxidative stress. To our knowledge this report on large-scales proteomics of breast cancer is currently a unique approach in the literature that offers the opportunity to evaluate the presence and recurrence of proteins to be used as prognostic indicators and susceptibility to metastasis in patients operated on for invasive ductal carcinoma of the breast.


Author(s):  
Kenichi SAKURAI ◽  
Saki NAGASHIMA ◽  
Shuhei SUZUKI ◽  
Katsuhisa ENOMOTO ◽  
Masahiko SUGITANI ◽  
...  

1996 ◽  
Vol 57 (8) ◽  
pp. 1881-1884
Author(s):  
Mikihiro KUSAMA ◽  
Hiroshi KAISE ◽  
Hideo KOU ◽  
Tatsuya AOKI ◽  
Yasuhisa KOYANAGI ◽  
...  

2014 ◽  
Vol 7 (4) ◽  
pp. 1001-1006 ◽  
Author(s):  
MIKAKO TAMAOKI ◽  
YOSHINORI NIO ◽  
KAZUHIKO TSUBOI ◽  
MARIKA NIO ◽  
MASASHI TAMAOKI ◽  
...  

Author(s):  
Osamu SENGA ◽  
Gengo KANEKO ◽  
Hitoshi HIKITA ◽  
Naoto HORIGOME ◽  
Manabu HIRAGURI ◽  
...  

2012 ◽  
Vol 48 ◽  
pp. S90
Author(s):  
N. Tamura ◽  
H. Tsuda ◽  
T. Kinoshita ◽  
Y. Fujiwara ◽  
K. Sugihara

1999 ◽  
Vol 60 (5) ◽  
pp. 1224-1228
Author(s):  
Hiroshi NARITA ◽  
Tatehiro WAKASUGI ◽  
Katsumi KATO ◽  
Motoki HATO ◽  
Akitoshi ITO ◽  
...  

2008 ◽  
Vol 20 (2) ◽  
pp. 117-121
Author(s):  
Yuko TSUNODA ◽  
Yukiko SHIMIZU ◽  
Eisuke FUKUMA ◽  
Masafumi TAKIMOTO ◽  
Akira TSUNODA ◽  
...  

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